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ATP released by muscle cells after electrical stimulation through pannexin-1 channels plays a key role in this process. We show now that stimulation frequency determines both ATP release and Ins(1,4,5)P3 production in adult skeletal muscle and that Cav1.1 and pannexin-1 colocalize in the transverse tubules. Both ATP release and increased Ins(1,4,5)P3 was seen in flexor digitorum brevis fibers stimulated with 270 pulses at 20\u2005Hz, but not at 90\u2005Hz. 20\u2005Hz stimulation induced transcriptional changes related to fast-to-slow muscle fiber phenotype transition that required ATP release. Addition of 30\u2005\u00b5M ATP to fibers induced the same transcriptional changes observed after 20\u2005Hz stimulation. Myotubes lacking the Cav1.1-\u03b11 subunit released almost no ATP after electrical stimulation, showing that Cav1.1 has a central role in this process. In adult muscle fibers, ATP release and the transcriptional changes produced by 20\u2005Hz stimulation were blocked by both the Cav1.1 antagonist nifedipine (25\u2005\u00b5M) and by the Cav1.1 agonist (-)S-BayK 8644 (10\u2005\u00b5M). We propose a new role for Cav1.1, independent of its calcium channel activity, in the activation of signaling pathways allowing muscle fibers to decipher the frequency of electrical stimulation and to activate specific transcriptional programs that define their phenotype.<\/jats:p>","DOI":"10.1242\/jcs.116855","type":"journal-article","created":{"date-parts":[[2013,1,16]],"date-time":"2013-01-16T05:30:10Z","timestamp":1358314210000},"page":"1189-1198","source":"Crossref","is-referenced-by-count":57,"title":["Cav1.1 controls frequency-dependent events regulating adult skeletal muscle plasticity"],"prefix":"10.1242","volume":"126","author":[{"given":"Gonzalo","family":"Jorquera","sequence":"first","affiliation":[{"name":"Centro de Estudios Moleculares de la C\u00e9lula, ICBM, Facultad de Medicina, Universidad de Chile, Independencia 1027-8380453, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Altamirano","sequence":"additional","affiliation":[{"name":"Centro de Estudios Moleculares de la C\u00e9lula, ICBM, Facultad de Medicina, Universidad de Chile, Independencia 1027-8380453, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Contreras-Ferrat","sequence":"additional","affiliation":[{"name":"Centro de Estudios Moleculares de la C\u00e9lula, ICBM, Facultad de Medicina, Universidad de Chile, Independencia 1027-8380453, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Almarza","sequence":"additional","affiliation":[{"name":"Centro de Estudios Moleculares de la C\u00e9lula, ICBM, Facultad de Medicina, Universidad de Chile, Independencia 1027-8380453, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Buvinic","sequence":"additional","affiliation":[{"name":"Centro de Estudios Moleculares de la C\u00e9lula, ICBM, Facultad de Medicina, Universidad de Chile, Independencia 1027-8380453, Santiago, Chile"},{"name":"Departamento de Ciencias B\u00e1sicas y Comunitarias, Facultad de Odontolog\u00eda, Universidad de Chile, Sergio Livingstone Pohlhammer 943-8380492, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Jacquemond","sequence":"additional","affiliation":[{"name":"CNRS, UMR 5534, Universit\u00e9 Lyon 1, Centre de G\u00e9n\u00e9tique et de Physiologie Mol\u00e9culaire et Cellulaire, B\u00e2timent Rapha\u00ebl Dubois, 43 Boulevard du 11 novembre 1918, 69622 Villeurbanne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Jaimovich","sequence":"additional","affiliation":[{"name":"Centro de Estudios Moleculares de la C\u00e9lula, ICBM, Facultad de Medicina, Universidad de Chile, Independencia 1027-8380453, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Casas","sequence":"additional","affiliation":[{"name":"Centro de Estudios Moleculares de la C\u00e9lula, ICBM, Facultad de Medicina, Universidad de Chile, Independencia 1027-8380453, Santiago, Chile"},{"name":"Programa de Fisiolog\u00eda y Biof\u00edsica, Instituto de Ciencias Biom\u00e9dicas, Facultad de Medicina, Universidad de Chile, Independencia 1027-8380453, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021111216273519600_b1","first-page":"7019","article-title":"cis-acting sequences of the rat troponin I slow gene confer tissue- and development-specific transcription in cultured muscle cells as well as fiber type specificity in transgenic mice.","volume":"13","author":"Banerjee\u2013Basu","year":"1993","journal-title":"Mol. 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