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Electron microscopy identified abnormal immature cells, overlying the mutant granular cells, which accumulated autophagosomes, glycogen granules and dead nuclei. Cell culture analysis showed that loss of p18 attenuated lysosome function, resulting in accumulation of immature lysosomes and autophagosomes. Analyses of lysosome behavior revealed that p18 is required for functional interaction between lysosomes and target organelles including autophagosomes. These findings suggest that p18-mediated pathways control lysosome-mediated catabolic processes crucial role for development of mouse epidermis.<\/jats:p>","DOI":"10.1242\/jcs.121913","type":"journal-article","created":{"date-parts":[[2013,6,19]],"date-time":"2013-06-19T02:30:31Z","timestamp":1371609031000},"source":"Crossref","is-referenced-by-count":26,"title":["The lysosomal signaling anchor p18\/LAMTOR1 controls epidermal development by regulating lysosome-mediated catabolic processes"],"prefix":"10.1242","author":[{"given":"Taeko","family":"Soma-Nagae","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeyuki","family":"Nada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Kitagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chitose","family":"Oneyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Okada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2013,1,1]]},"reference":[{"key":"2021042613075732300_b1","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1016\/j.cell.2012.07.032","article-title":"Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.","volume":"150","author":"Bar-Peled","year":"2012","journal-title":"Cell"},{"key":"2021042613075732300_b2","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/nm1528","article-title":"A novel human primary immunodeficiency syndrome caused by deficiency of the endosomal adaptor protein p14.","volume":"13","author":"Bohn","year":"2007","journal-title":"Nat. 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