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For example, there are excellent models to describe cancer incidence rates or factors for early disease detection, but these predictions are unable to explain the functional and molecular changes that are associated with tumour progression. In addition, it is crucial that interactions between mechanical effects, and intracellular and intercellular signalling are incorporated in order to understand cancer growth, its interaction with the extracellular microenvironment and invasion of secondary sites. There is a compelling need to tailor new, physiologically relevant in silico models that are specialised for particular types of cancer, such as ovarian cancer owing to its unique route of metastasis, which are capable of investigating anti-cancer therapies, and generating both qualitative and quantitative predictions. This Commentary will focus on how computational simulation approaches can advance our understanding of ovarian cancer progression and treatment, in particular, with the help of multicellular cancer spheroids, and thus, can inform biological hypothesis and experimental design.<\/jats:p>","DOI":"10.1242\/jcs.123836","type":"journal-article","created":{"date-parts":[[2013,8,5]],"date-time":"2013-08-05T22:22:40Z","timestamp":1375741360000},"source":"Crossref","is-referenced-by-count":20,"title":["A multiscale road map of cancer spheroids \u2013 incorporating experimental and mathematical modelling to understand cancer progression"],"prefix":"10.1242","author":[{"given":"Daniela","family":"Loessner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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