{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T05:45:13Z","timestamp":1780465513728,"version":"3.54.1"},"reference-count":41,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2014,8,15]],"date-time":"2014-08-15T00:00:00Z","timestamp":1408060800000},"content-version":"vor","delay-in-days":591,"URL":"http:\/\/www.biologists.com\/user-licence-1-1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>The kinesin motors are important in the regulation of cellular functions such as protein trafficking, spindle organization and centrosome separation. In this study, we have identified POPX2, a serine-threonine phosphatase, as an interacting partner of the KAP3 subunit of the kinesin-2 motor. The kinesin-2 motor is a heterotrimeric complex composed of KIF3A, KIF3B motor subunits and KAP3, the non-motor subunit, which binds the cargo. Here we report that the phosphatase POPX2 is a negative regulator of the trafficking of N-cadherin and other cargoes; consequently, it markedly influences cell-cell adhesion. POPX2 affects trafficking by determining the phosphorylation status of KIF3A at serine-690. This is consistent with the observation that KIF3A-S690A mutant is defective in cargo trafficking. Our studies also implicate CaMKII as the kinase that phosphorylates KIF3A at serine-690. These results strongly suggest POPX2 and CaMKII as the phosphatase-kinase pair that regulates kinesin-mediated transport and cell-cell adhesion.<\/jats:p>","DOI":"10.1242\/jcs.126482","type":"journal-article","created":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T06:11:41Z","timestamp":1386828701000},"source":"Crossref","is-referenced-by-count":20,"title":["POPX2 phosphatase regulates the KIF3 kinesin motor complex"],"prefix":"10.1242","author":[{"given":"Hui-Qun","family":"Phang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Ling","family":"Hoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soak Kuan","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukai","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keng-Hwee","family":"Chiam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoi Yeung","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Gee","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2013,1,1]]},"reference":[{"key":"2021042614251214000_b1","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1074\/mcp.M400085-MCP200","article-title":"Phosphoproteomic analysis of the developing mouse brain.","volume":"3","author":"Ballif","year":"2004","journal-title":"Mol. 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