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Here, we show that paxillin knockdown enhances endothelial cell migration in vitro and stimulates angiogenesis during normal development and in response to tumor angiogenic factors in vivo. Paxillin produces these effects by decreasing expression of neuropilin 2 (NRP2). Moreover, soluble factors secreted by tumors that stimulate vascular ingrowth, including vascular endothelial growth factor (VEGF), also decrease endothelial cell expression of paxillin and NRP2, and overexpression of NRP2 reverses these effects. These results suggest that the VEGF\u2013paxillin\u2013NRP2 pathway could represent a new therapeutic target for cancer and other angiogenesis-related diseases.<\/jats:p>","DOI":"10.1242\/jcs.132316","type":"journal-article","created":{"date-parts":[[2014,2,13]],"date-time":"2014-02-13T03:05:18Z","timestamp":1392260718000},"page":"1672-1683","source":"Crossref","is-referenced-by-count":41,"title":["Paxillin controls endothelial cell migration and tumor angiogenesis by altering neuropilin 2 expression"],"prefix":"10.1242","volume":"127","author":[{"given":"Alexandra E.","family":"German","sequence":"first","affiliation":[{"name":"Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, MA 02139, USA"},{"name":"Vascular Biology Program, Departments of Pathology & Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadanori","family":"Mammoto","sequence":"additional","affiliation":[{"name":"Vascular Biology Program, Departments of Pathology & Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Jiang","sequence":"additional","affiliation":[{"name":"Vascular Biology Program, Departments of Pathology & Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald E.","family":"Ingber","sequence":"additional","affiliation":[{"name":"Vascular Biology Program, Departments of Pathology & Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA"},{"name":"Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA"},{"name":"Harvard School of Engineering and Applied Sciences, Cambridge, MA 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Mammoto","sequence":"additional","affiliation":[{"name":"Vascular Biology Program, Departments of Pathology & Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021080923264554200_b1","doi-asserted-by":"publisher","first-page":"15442","DOI":"10.1074\/jbc.272.24.15442","article-title":"Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells.","volume":"272","author":"Abedi","year":"1997","journal-title":"J. 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