{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T08:50:30Z","timestamp":1772268630368,"version":"3.50.1"},"reference-count":68,"publisher":"The Company of Biologists","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Epithelial junctions are fundamental determinants of tissue organization, subject to regulation by tyrosine phosphorylation. E-cadherin homophilic binding activates tyrosine kinases, such as Src, that controls junctional integrity. Protein tyrosine phosphatases (PTPs) also contribute to cadherin-based adhesion and signaling, but little is known about their specific identity or functions at epithelial junctions.<\/jats:p>\n               <jats:p>We report here that the receptor-PTP RPTP\u03b1 is recruited to epithelial adherens junctions at the time of cell-cell contact, where it is in molecular proximity to E-cadherin. RPTP\u03b1 is required for appropriate cadherin-dependent adhesion, and for cyst architecture in 3-dimensional culture. Loss of RPTP\u03b1 impairs adherens junction integrity, manifested by defective E-cadherin accumulation and perijunctional F-actin density. These effects correlate with a role for RPTP\u03b1 in c-Src activation at sites of E-cadherin engagement. Mechanistically, RPTP\u03b1 is required for appropriate tyrosine phosphorylation of cortactin, a major Src substrate and a cytoskeletal actin organizer. Expression of a phosphomimetic cortactin mutant in RPTP\u03b1-depleted cells partially rescues F-actin and E-cadherin accumulation at intercellular contacts.<\/jats:p>\n               <jats:p>These findings indicate that RPTP\u03b1 controls cadherin-mediated signaling by linking homophilic E-cadherin engagement to cortactin tyrosine phosphorylation via c-Src.<\/jats:p>","DOI":"10.1242\/jcs.134379","type":"journal-article","created":{"date-parts":[[2014,3,21]],"date-time":"2014-03-21T02:19:21Z","timestamp":1395368361000},"source":"Crossref","is-referenced-by-count":23,"title":["Receptor protein tyrosine phosphatase RPTP\u03b1 controls epithelial adherens junctions, linking E-cadherin engagement to c-Src signaling to cortactin"],"prefix":"10.1242","author":[{"given":"Marta","family":"Truffi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique","family":"Dubreuil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Vacaresse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabienne","family":"Nigon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siew Ping","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alpha S.","family":"Yap","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo A.","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Sap","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2014,1,1]]},"reference":[{"key":"2021042613222640800_b1","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1083\/jcb.135.6.1899","article-title":"Quantitative analysis of cadherin-catenin-actin reorganization during development of cell-cell adhesion.","volume":"135","author":"Adams","year":"1996","journal-title":"J. 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