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Insufficiency of SMN results in the inherited neurodegenerative condition, Spinal Muscular Atrophy (SMA). Details of the physical organization of the cytoplasmic stages of snRNP biogenesis are unknown. We have used time-resolved quantitative proteomics to identify proteins that associate preferentially with either newly assembled or mature splicing snRNPs. These data have allowed us to identify highly mobile SmB protein trafficking vesicles in neural cells. These vesicles are dependent on the cellular levels of SMN and SmB for their morphology and mobility. We propose that these represent a family of related vesicles, some of which play a role in snRNP biogenesis and some of which may play more diverse roles in cellular RNA metabolism.<\/jats:p>","DOI":"10.1242\/jcs.137703","type":"journal-article","created":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T03:20:54Z","timestamp":1387509654000},"source":"Crossref","is-referenced-by-count":9,"title":["Time-resolved quantitative proteomics implicates the core snRNP protein, SmB, together with the Survival of Motor Neuron protein, in neural trafficking"],"prefix":"10.1242","author":[{"given":"Alan R","family":"Prescott","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Bales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"James","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Trinkle-Mulcahy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith E.","family":"Sleeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2013,1,1]]},"reference":[{"key":"2021042614260384600_b1","doi-asserted-by":"publisher","first-page":"4154","DOI":"10.1091\/mbc.E08-05-0513","article-title":"The dynamics of mammalian P body transport, assembly, and disassembly in vivo.","volume":"19","author":"Aizer","year":"2008","journal-title":"Mol. 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