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Implantation, pregnancy and embryogenesis are distinct from any other process in the body, with extensive, but controlled, proliferation, cell migration, apoptosis, cell invasion and differentiation. Cellular plasticity is vital during the early stages of development for morphogenesis and organ homeostasis, effecting the epithelial to mesenchymal transition (EMT) and, the reverse process, mesenchymal to epithelial transition (MET). STAT3 functionally associates with MCL-1 in the mammalian breast cancer cell line MCF7 that overexpresses STAT3 and MCL-1, which leads to an increased rate of apoptosis and decreased cellular invasion, disrupting the EMT. Association of MCL-1 with STAT3 modulates the normal, anti-apoptotic, activity of MCL-1, resulting in pro-apoptotic effects. Studying the impact of the association of STAT3 with MCL-1 on MET could lead to an enhanced understanding of pregnancy and infertility, and also metastatic tumors.<\/jats:p>","DOI":"10.1242\/jcs.138214","type":"journal-article","created":{"date-parts":[[2014,1,31]],"date-time":"2014-01-31T02:23:17Z","timestamp":1391134997000},"page":"1738-1750","source":"Crossref","is-referenced-by-count":23,"title":["STAT3 and MCL-1 associate to cause a mesenchymal epithelial transition"],"prefix":"10.1242","volume":"127","author":[{"given":"A. 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