{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:09:46Z","timestamp":1791169786944,"version":"4.1.0"},"reference-count":35,"publisher":"The Company of Biologists","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Cajal bodies (CBs) are nuclear organelles involved in the maturation of spliceosomal snRNPs. They concentrate coilin, snRNPs and the survival motor neuron protein (SMN). Dysfunction of CB assembly is an essential component of spinal muscular atrophy (SMA). Here we demonstrate that SMN is a SUMO1 target that has a SUMO-like interacting motif (SIM-like) in the Tudor domain. The expression of SIM-like mutant constructs abolishes the interaction of SMN with the spliceosomal SmD1, severely decreases SMN-coilin interaction and prevents CB assembly. Accordingly, the SMN SIM-like-mediated interactions are important for CB biogenesis and their dysfunction can be involved in SMA pathophysiology.<\/jats:p>","DOI":"10.1242\/jcs.138537","type":"journal-article","created":{"date-parts":[[2014,1,11]],"date-time":"2014-01-11T03:14:28Z","timestamp":1389410068000},"source":"Crossref","is-referenced-by-count":19,"title":["The SMN Tudor SIM-like domain is key to SmD1 and coilin interactions and to Cajal body biogenesis"],"prefix":"10.1242","author":[{"given":"Olga","family":"Tapia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanesa","family":"Lafarga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocio","family":"Bengoechea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Palanca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Lafarga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda T.","family":"Berciano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2014,1,1]]},"reference":[{"key":"2021042613435634000_b1","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.1093\/hmg\/8.13.2351","article-title":"Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: implications for spinal muscular atrophy.","volume":"8","author":"B\u00fchler","year":"1999","journal-title":"Hum. 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