{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:17:29Z","timestamp":1790612249923,"version":"4.1.0"},"reference-count":52,"publisher":"The Company of Biologists","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>We describe altered sortilin sorting in AP-1\/\u03c31B complex deficient adipocytes, which leads to the inhibition of adipogenesis. The AP-1 complex mediates protein sorting between the trans-Golgi network and endosomes. Vertebrates express three \u03c31-subunit isoforms: \u03c31A, \u03c31B and \u03c31C. \u03c31B \u2212\/\u2212 mice have impaired synaptic-vesicle recycling and a lipodystrophy. Sortilin is over-expressed in \u03c31B \u2212\/\u2212 adipose tissue and its over-expression in wild-type cells is sufficient to suppress adipogenesis. \u03c31B-specific binding of sortilin requires its DxxD-x12-DSxxxL motif. \u03c31B-deficiency does not lead to a block of sortilin transport out of a specific organelle, but the fraction which reaches lysosomes is reduced. Sortilin binds the DLK1 receptor, an inhibitor of adipocyte differentiation, and sortilin overexpression prevents DLK1 down-regulation, which leads to enhanced inhibition of adipogenesis. DLK1 and sortilin expression are not increased in the brain, although it is the tissue of highest \u03c31B and sortilin expression. Thus adipose tissue specific and \u03c31B-dependent routes for transport of sortilin exist and take part in the regulation of adipogenesis and adipose-tissue mass.<\/jats:p>","DOI":"10.1242\/jcs.146886","type":"journal-article","created":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T14:31:26Z","timestamp":1402929086000},"source":"Crossref","is-referenced-by-count":18,"title":["\u03c31B-adaptin sorts sortilin in adipose tissue regulating adipogenesis"],"prefix":"10.1242","author":[{"given":"Jennifer","family":"Baltes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob Vejby","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthikeyan","family":"Radhakrishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constanze","family":"Geumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Kratzke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus Munck","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Schu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2014,1,1]]},"reference":[{"key":"2021042613360547400_b1","doi-asserted-by":"publisher","first-page":"2907","DOI":"10.1091\/mbc.12.10.2907","article-title":"Adaptins: the final recount.","volume":"12","author":"Boehm","year":"2001","journal-title":"Mol. 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