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CFTR inhibition or knockdown reduces ZO-1 expression and induces the translocation of the transcription factor ZONAB from TJs to the nucleus, followed by up-regulation of CCND1 and down-regulation of ErbB2. The epididymal tubules of cftr\u2212\/\u2212 and cftr\u0394F508 mice have reduced ZO-1 levels, increased ZONAB nuclear expression, and decreased epithelial cell differentiation, illustrated by the reduced expression of apical AQP9 and V-ATPase. This study provides a new paradigm for the etiology of diseases associated with CFTR mutations, including cystic fibrosis.<\/jats:p>","DOI":"10.1242\/jcs.148098","type":"journal-article","created":{"date-parts":[[2014,8,9]],"date-time":"2014-08-09T00:42:48Z","timestamp":1407544968000},"source":"Crossref","is-referenced-by-count":58,"title":["CFTR interacts with ZO-1 to regulate tight junction assembly and epithelial differentiation via the ZONAB pathway"],"prefix":"10.1242","author":[{"given":"Ye Chun","family":"Ruan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bongki","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui Ying","family":"Diao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiao Chang","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Breton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2014,1,1]]},"reference":[{"key":"2021042613412907500_b1","doi-asserted-by":"publisher","first-page":"1794","DOI":"10.1001\/jama.1992.03480130110034","article-title":"Congenital bilateral absence of the vas deferens. 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