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We here investigate the impact of the N-cadherin adhesion molecule on collective glial migration using the Drosophila developing wing and cell-type specific manipulation of gene expression. We show that N-cadherin timely accumulates in glial cells and that its levels affect migration efficiency. N-cadherin works as a molecular brake in a dosage dependent manner by negatively controlling actin nucleation and cytoskeleton remodeling through \u03b1\/\u03b2 catenins. This is the first in vivo evidence for N-cadherin negatively and cell autonomously controlling collective migration.<\/jats:p>","DOI":"10.1242\/jcs.157974","type":"journal-article","created":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T03:29:54Z","timestamp":1421378994000},"source":"Crossref","is-referenced-by-count":15,"title":["N-cadherin negatively regulates collective <i>Drosophila<\/i> glial migration via actin cytoskeleton remodeling"],"prefix":"10.1242","author":[{"given":"Arun","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tripti","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Berzsenyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Giangrande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2015,1,1]]},"reference":[{"key":"2021042613493349800_b1","doi-asserted-by":"publisher","first-page":"5127","DOI":"10.1242\/dev.01398","article-title":"Time-lapse and cell ablation reveal the role of cell interactions in fly glia migration and proliferation.","volume":"131","author":"Aigouy","year":"2004","journal-title":"Development"},{"key":"2021042613493349800_b2","doi-asserted-by":"publisher","first-page":"11635","DOI":"10.1523\/JNEUROSCI.1361-08.2008","article-title":"Glial chain migration requires pioneer cells.","volume":"28","author":"Aigouy","year":"2008","journal-title":"J. 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