{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:32:29Z","timestamp":1791279149375,"version":"4.1.0"},"reference-count":62,"publisher":"The Company of Biologists","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>The cadherin-catenin adhesion complex is a key contributor to epithelial tissue stability and dynamic cell movements during development and tissue renewal. How this complex is regulated to accomplish these functions is not fully understood. We identified several phosphorylation sites in mammalian \u03b1E-catenin and Drosophila \u03b1-Catenin within a flexible linker located between the middle (M)-region and the carboxyl-terminal actin-binding domain. We show that this phospho-linker (P-linker) is the main phosphorylated region of \u03b1-catenin in cells and is sequentially modified at Casein Kinase 2 and 1 consensus sites. In Drosophila, the P-linker is required for normal \u03b1-catenin function during development and collective cell migration, although no obvious defects were found in cadherin-catenin complex assembly or adherens junction formation. In mammalian cells, non-phosphorylatable forms of \u03b1-catenin showed defects in intercellular adhesion using a mechanical dispersion assay. Epithelial sheets expressing phospho-mimic forms of \u03b1-catenin showed faster and more coordinated migrations after scratch wounding. These findings suggest that phosphorylation and dephosphorylation of the \u03b1-catenin P-linker are required for normal cadherin-catenin complex function in Drosophila and mammalian cells.<\/jats:p>","DOI":"10.1242\/jcs.163824","type":"journal-article","created":{"date-parts":[[2015,2,5]],"date-time":"2015-02-05T03:59:03Z","timestamp":1423108743000},"source":"Crossref","is-referenced-by-count":42,"title":["\u03b1-catenin phosphorylation promotes intercellular adhesion through a dual-kinase mechanism"],"prefix":"10.1242","author":[{"given":"D.J.","family":"Escobar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Ishiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.S.","family":"Folmsbee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.N.","family":"Novak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.S.","family":"Flozak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.L.","family":"Daugherty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Nanavati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Sarpal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Leckband","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ikura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Tepass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.J.","family":"Gottardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2015,1,1]]},"reference":[{"key":"2021042613472017700_b1","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1074\/mcp.M400085-MCP200","article-title":"Phosphoproteomic analysis of the developing mouse brain.","volume":"3","author":"Ballif","year":"2004","journal-title":"Mol. Cell. Proteomics"},{"key":"2021042613472017700_b2","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1242\/jcs.139014","article-title":"\u03b1-catenin cytomechanics \u2013 role in cadherin-dependent adhesion and mechanotransduction.","volume":"127","author":"Barry","year":"2014","journal-title":"J. Cell Sci."},{"key":"2021042613472017700_b3","doi-asserted-by":"publisher","first-page":"28314","DOI":"10.1074\/jbc.273.43.28314","article-title":"Modification of the E-cadherin-catenin complex in mitotic Madin-Darby canine kidney epithelial cells.","volume":"273","author":"Bauer","year":"1998","journal-title":"J. Biol. Chem."},{"key":"2021042613472017700_b4","doi-asserted-by":"publisher","first-page":"12130","DOI":"10.1073\/pnas.0404720101","article-title":"Large-scale characterization of HeLa cell nuclear phosphoproteins.","volume":"101","author":"Beausoleil","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042613472017700_b5","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1083\/jcb.200910041","article-title":"AlphaE-catenin regulates actin dynamics independently of cadherin-mediated cell-cell adhesion.","volume":"189","author":"Benjamin","year":"2010","journal-title":"J. Cell Biol."},{"key":"2021042613472017700_b6","doi-asserted-by":"publisher","first-page":"1254211","DOI":"10.1126\/science.1254211","article-title":"Cell adhesion. The minimal cadherin-catenin complex binds to actin filaments under force.","volume":"346","author":"Buckley","year":"2014","journal-title":"Science"},{"key":"2021042613472017700_b7","doi-asserted-by":"publisher","first-page":"7166","DOI":"10.1038\/sj.onc.1209728","article-title":"Modulation of alpha-catenin Tyr phosphorylation by SHP2 positively effects cell transformation induced by the constitutively active FGFR3.","volume":"25","author":"Burks","year":"2006","journal-title":"Oncogene"},{"key":"2021042613472017700_b8","doi-asserted-by":"publisher","first-page":"2880","DOI":"10.1074\/jbc.M807417200","article-title":"alpha- and gamma-Protocadherins negatively regulate PYK2.","volume":"284","author":"Chen","year":"2009","journal-title":"J. Biol. Chem."},{"key":"2021042613472017700_b9","doi-asserted-by":"publisher","first-page":"8576","DOI":"10.1073\/pnas.1203906109","article-title":"\u03b1E-catenin is an autoinhibited molecule that coactivates vinculin.","volume":"109","author":"Choi","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042613472017700_b10","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1083\/jcb.141.1.297","article-title":"A putative catenin-cadherin system mediates morphogenesis of the Caenorhabditis elegans embryo.","volume":"141","author":"Costa","year":"1998","journal-title":"J. Cell Biol."},{"key":"2021042613472017700_b11","doi-asserted-by":"publisher","first-page":"5260","DOI":"10.1073\/pnas.1308663111","article-title":"\u03b1-Catenin is an inhibitor of transcription.","volume":"111","author":"Daugherty","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042613472017700_b12","doi-asserted-by":"publisher","first-page":"10762","DOI":"10.1073\/pnas.0805139105","article-title":"A quantitative atlas of mitotic phosphorylation.","volume":"105","author":"Dephoure","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042613472017700_b13","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/ncb2685","article-title":"Monomeric \u03b1-catenin links cadherin to the actin cytoskeleton.","volume":"15","author":"Desai","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"2021042613472017700_b14","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1016\/j.cell.2005.09.021","article-title":"Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly.","volume":"123","author":"Drees","year":"2005","journal-title":"Cell"},{"key":"2021042613472017700_b15","doi-asserted-by":"publisher","first-page":"3804","DOI":"10.1128\/MCB.01590-06","article-title":"Casein kinase 1 is a novel negative regulator of E-cadherin-based cell-cell contacts.","volume":"27","author":"Dupre-Crochet","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"2021042613472017700_b16","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1534\/genetics.166.4.1775","article-title":"Construction of transgenic Drosophila by using the site-specific integrase from phage phiC31.","volume":"166","author":"Groth","year":"2004","journal-title":"Genetics"},{"key":"2021042613472017700_b17","doi-asserted-by":"publisher","first-page":"2808","DOI":"10.1242\/dev.089896","article-title":"The Maf factor Traffic jam both enables and inhibits collective cell migration in Drosophila oogenesis.","volume":"140","author":"Gunawan","year":"2013","journal-title":"Development"},{"key":"2021042613472017700_b18","doi-asserted-by":"publisher","first-page":"4261","DOI":"10.1091\/mbc.E07-04-0308","article-title":"Transcriptional modulation of genes encoding structural characteristics of differentiating enterocytes during development of a polarized epithelium in vitro.","volume":"18","author":"Halbleib","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"2021042613472017700_b19","doi-asserted-by":"publisher","first-page":"3710","DOI":"10.1091\/mbc.E13-07-0388","article-title":"\u03b1E-catenin actin-binding domain alters actin filament conformation and regulates binding of nucleation and disassembly factors.","volume":"24","author":"Hansen","year":"2013","journal-title":"Mol. Biol. Cell"},{"key":"2021042613472017700_b20","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/B978-0-12-394304-0.00007-5","article-title":"Adherens junction assembly and function in the Drosophila embryo.","volume":"293","author":"Harris","year":"2012","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"2021042613472017700_b21","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1038\/nrm2927","article-title":"Adherens junctions: from molecules to morphogenesis.","volume":"11","author":"Harris","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2021042613472017700_b22","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1083\/jcb.201211054","article-title":"Binding to F-actin guides cadherin cluster assembly, stability, and movement.","volume":"201","author":"Hong","year":"2013","journal-title":"J. Cell Biol."},{"key":"2021042613472017700_b23","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1016\/j.cell.2010.12.001","article-title":"A tissue-specific atlas of mouse protein phosphorylation and expression.","volume":"143","author":"Huttlin","year":"2010","journal-title":"Cell"},{"key":"2021042613472017700_b24","doi-asserted-by":"publisher","first-page":"15913","DOI":"10.1074\/jbc.M113.453928","article-title":"An autoinhibited structure of \u03b1-catenin and its implications for vinculin recruitment to adherens junctions.","volume":"288","author":"Ishiyama","year":"2013","journal-title":"J. Biol. Chem."},{"key":"2021042613472017700_b25","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.molcel.2009.09.034","article-title":"EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin.","volume":"36","author":"Ji","year":"2009","journal-title":"Mol. Cell"},{"key":"2021042613472017700_b26","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1038\/nrm1433","article-title":"Alpha-catenin: at the junction of intercellular adhesion and actin dynamics.","volume":"5","author":"Kobielak","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2021042613472017700_b27","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1083\/jcb.201001149","article-title":"Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner.","volume":"189","author":"le Duc","year":"2010","journal-title":"J. Cell Biol."},{"key":"2021042613472017700_b28","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/S0896-6273(00)80701-1","article-title":"Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis.","volume":"22","author":"Lee","year":"1999","journal-title":"Neuron"},{"key":"2021042613472017700_b29","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1126\/science.1121449","article-title":"alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway.","volume":"311","author":"Lien","year":"2006","journal-title":"Science"},{"key":"2021042613472017700_b30","doi-asserted-by":"publisher","first-page":"e10184","DOI":"10.1371\/journal.pone.0010184","article-title":"Beta-catenin phosphorylated at serine 45 is spatially uncoupled from beta-catenin phosphorylated in the GSK3 domain: implications for signaling.","volume":"5","author":"Maher","year":"2010","journal-title":"PLoS ONE"},{"key":"2021042613472017700_b31","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1083\/jcb.201103106","article-title":"The secret life of \u03b1-catenin: moonlighting in morphogenesis.","volume":"195","author":"Maiden","year":"2011","journal-title":"J. Cell Biol."},{"key":"2021042613472017700_b32","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1006\/bbrc.1994.1128","article-title":"Design and synthesis of two new peptide substrates for the specific and sensitive monitoring of casein kinases-1 and -2.","volume":"198","author":"Marin","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021042613472017700_b33","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.1091\/mbc.E14-01-0690","article-title":"E-cadherin phosphorylation occurs during its biosynthesis to promote its cell surface stability and adhesion.","volume":"25","author":"McEwen","year":"2014","journal-title":"Mol. Biol. Cell"},{"key":"2021042613472017700_b34","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1016\/j.cub.2008.03.024","article-title":"Regulation of cell adhesion and collective cell migration by hindsight and its human homolog RREB1.","volume":"18","author":"Melani","year":"2008","journal-title":"Curr. Biol."},{"key":"2021042613472017700_b35","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1038\/nrm3433","article-title":"Group choreography: mechanisms orchestrating the collective movement of border cells.","volume":"13","author":"Montell","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2021042613472017700_b36","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1083\/jcb.144.3.533","article-title":"DE-Cadherin is required for intercellular motility during Drosophila oogenesis.","volume":"144","author":"Niewiadomska","year":"1999","journal-title":"J. Cell Biol."},{"key":"2021042613472017700_b37","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/S0070-2153(09)89002-9","article-title":"Remodeling of the adherens junctions during morphogenesis.","volume":"89","author":"Nishimura","year":"2009","journal-title":"Curr. Top. Dev. Biol."},{"key":"2021042613472017700_b38","doi-asserted-by":"publisher","first-page":"4184","DOI":"10.1128\/MCB.24.10.4184-4195.2004","article-title":"A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1.","volume":"24","author":"Okamura","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"2021042613472017700_b39","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.cell.2006.09.026","article-title":"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.","volume":"127","author":"Olsen","year":"2006","journal-title":"Cell"},{"key":"2021042613472017700_b40","doi-asserted-by":"publisher","first-page":"9220","DOI":"10.1073\/pnas.94.17.9220","article-title":"Identification of genes required for Drosophila eye development using a phenotypic enhancer-trap.","volume":"94","author":"Pignoni","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042613472017700_b41","doi-asserted-by":"publisher","first-page":"18868","DOI":"10.1074\/jbc.M201463200","article-title":"Biochemical and structural definition of the l-afadin- and actin-binding sites of alpha-catenin.","volume":"277","author":"Pokutta","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2021042613472017700_b42","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1046\/j.1432-1327.1999.00195.x","article-title":"Optimal sequences for non-phosphate-directed phosphorylation by protein kinase CK1 (casein kinase-1) \u2013 a re-evaluation.","volume":"260","author":"Pulgar","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"2021042613472017700_b43","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1038\/nsmb.2479","article-title":"Dimer asymmetry defines \u03b1-catenin interactions.","volume":"20","author":"Rangarajan","year":"2013","journal-title":"Nat. Struct. Mol. Biol."},{"key":"2021042613472017700_b44","doi-asserted-by":"publisher","first-page":"36734","DOI":"10.1074\/jbc.274.51.36734","article-title":"Regulation of E-cadherin\/Catenin association by tyrosine phosphorylation.","volume":"274","author":"Roura","year":"1999","journal-title":"J. Biol. Chem."},{"key":"2021042613472017700_b45","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1242\/jcs.096644","article-title":"Mutational analysis supports a core role for Drosophila \u03b1-catenin in adherens junction function.","volume":"125","author":"Sarpal","year":"2012","journal-title":"J. Cell Sci."},{"key":"2021042613472017700_b46","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1242\/dev.118.2.629","article-title":"Catenins in Xenopus embryogenesis and their relation to the cadherin-mediated cell-cell adhesion system.","volume":"118","author":"Schneider","year":"1993","journal-title":"Development"},{"key":"2021042613472017700_b47","doi-asserted-by":"publisher","first-page":"3493","DOI":"10.1242\/dev.01911","article-title":"Function of the ETS transcription factor Yan in border cell migration.","volume":"132","author":"Schober","year":"2005","journal-title":"Development"},{"key":"2021042613472017700_b48","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1038\/ncb1762","article-title":"Identification of genes that regulate epithelial cell migration using an siRNA screening approach.","volume":"10","author":"Simpson","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"2021042613472017700_b49","doi-asserted-by":"publisher","first-page":"319","DOI":"10.3109\/15419069409014207","article-title":"A short core region of E-cadherin is essential for catenin binding and is highly phosphorylated.","volume":"2","author":"Stappert","year":"1994","journal-title":"Cell Adhes. Commun."},{"key":"2021042613472017700_b50","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.devcel.2011.12.025","article-title":"Abl regulates planar polarized junctional dynamics through \u03b2-catenin tyrosine phosphorylation.","volume":"22","author":"Tamada","year":"2012","journal-title":"Dev. Cell"},{"key":"2021042613472017700_b51","doi-asserted-by":"publisher","first-page":"5354","DOI":"10.1021\/pr200611n","article-title":"Universal and confident phosphorylation site localization using phosphoRS.","volume":"10","author":"Taus","year":"2011","journal-title":"J. Proteome Res."},{"key":"2021042613472017700_b52","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1002\/ibd.21375","article-title":"Genetics of ulcerative colitis.","volume":"17","author":"Thompson","year":"2011","journal-title":"Inflamm. Bowel Dis."},{"key":"2021042613472017700_b53","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1083\/jcb.148.1.189","article-title":"Selective uncoupling of p120(ctn) from E-cadherin disrupts strong adhesion.","volume":"148","author":"Thoreson","year":"2000","journal-title":"J. Cell Biol."},{"key":"2021042613472017700_b54","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1136\/gut.2010.233460","article-title":"\u03b2-catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesis.","volume":"60","author":"van Veelen","year":"2011","journal-title":"Gut"},{"key":"2021042613472017700_b55","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/S0092-8674(01)00246-X","article-title":"Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin.","volume":"104","author":"Vasioukhin","year":"2001","journal-title":"Cell"},{"key":"2021042613472017700_b56","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1172\/JCI200420702","article-title":"Src blockade stabilizes a Flk\/cadherin complex, reducing edema and tissue injury following myocardial infarction.","volume":"113","author":"Weis","year":"2004","journal-title":"J. Clin. Invest."},{"key":"2021042613472017700_b57","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1083\/jcb.141.3.755","article-title":"Vinculin is part of the cadherin-catenin junctional complex: complex formation between alpha-catenin and vinculin.","volume":"141","author":"Weiss","year":"1998","journal-title":"J. Cell Biol."},{"key":"2021042613472017700_b58","doi-asserted-by":"publisher","DOI":"10.4172\/2155-6121.S11-003","article-title":"The importance of bronchial epithelial junction integrity in asthma.","author":"Xiao","year":"2013","journal-title":"J. Aller. Ther"},{"key":"2021042613472017700_b59","doi-asserted-by":"publisher","first-page":"3645","DOI":"10.1093\/emboj\/20.14.3645","article-title":"Crystal structure of the M-fragment of alpha-catenin: implications for modulation of cell adhesion.","volume":"20","author":"Yang","year":"2001","journal-title":"EMBO J."},{"key":"2021042613472017700_b60","doi-asserted-by":"publisher","first-page":"4525","DOI":"10.1038\/ncomms5525","article-title":"Force-dependent conformational switch of \u03b1-catenin controls vinculin binding.","volume":"5","author":"Yao","year":"2014","journal-title":"Nat. Commun."},{"key":"2021042613472017700_b61","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1038\/ncb2055","article-title":"alpha-Catenin as a tension transducer that induces adherens junction development.","volume":"12","author":"Yonemura","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"2021042613472017700_b62","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1021\/pr700696a","article-title":"Phosphoproteome analysis of Drosophila melanogaster embryos.","volume":"7","author":"Zhai","year":"2008","journal-title":"J. Proteome Res."}],"container-title":["Journal of Cell Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.biologists.com\/jcs\/article-pdf\/128\/6\/1150\/1939789\/jcs-128-06-1150.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/jcs\/article-pdf\/doi\/10.1242\/jcs.163824\/2047511\/jcs163824.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/jcs\/article-pdf\/doi\/10.1242\/jcs.163824\/2047511\/jcs163824.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T18:08:19Z","timestamp":1621361299000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/jcs\/article\/doi\/10.1242\/jcs.163824\/260372\/catenin-phosphorylation-promotes-intercellular"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,1]]},"references-count":62,"URL":"https:\/\/doi.org\/10.1242\/jcs.163824","relation":{},"ISSN":["1477-9137","0021-9533"],"issn-type":[{"value":"1477-9137","type":"electronic"},{"value":"0021-9533","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1,1]]},"article-number":"jcs.163824"}}