{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T06:01:27Z","timestamp":1769061687571,"version":"3.49.0"},"reference-count":37,"publisher":"The Company of Biologists","issue":"2","license":[{"start":{"date-parts":[[1975,3,1]],"date-time":"1975-03-01T00:00:00Z","timestamp":162864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1975,3,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>A study has been made of the ribosomal RNA and chromosome constitution of man-mouse hybrid cells. Previous work has shown that no human 28\u2009s rRNA is detectable in man-mouse synkaryons. In general human chromosomes are lost from such hybrids.<\/jats:p>\n               <jats:p>With a recently developed method for distinguishing mouse from human chromosomes, an analysis of various man-mouse hybrid cell lines has been made. This indicates that not all the human chromosomes bearing nucleolar organizers are lost in the hybrid cells and such loss cannot alone explain the absence of human 28\u2009s rRNA.<\/jats:p>\n               <jats:p>An examination of the 28\u2009s rRNA synthesized by heterokaryons formed from several different parent cells has revealed that both parental types of 28\u2009s rRNA are present in heterokaryons. The control of rRNA synthesis in hybrid cells is discussed.<\/jats:p>","DOI":"10.1242\/jcs.17.3.307","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T20:37:01Z","timestamp":1619469421000},"page":"307-325","source":"Crossref","is-referenced-by-count":28,"title":["Synthesis of ribosomal RNA in synkaryons and heterokaryons formed between human and rodent cells"],"prefix":"10.1242","volume":"17","author":[{"given":"C. J.","family":"Marshall","sequence":"first","affiliation":[{"name":"Imperial Cancer Research Fund Laboratories, Lincoln\u2019s Inn Fields , London WC2A 3PX,","place":["England"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. D.","family":"Handmaker","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California Medical Center , San Francisco, California 94122,","place":["U.S.A."]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u039c. E.","family":"Bramwell","sequence":"additional","affiliation":[{"name":"Sir William Dunn School of Pathology, University of Oxford , OX 13 RE,","place":["England"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[1975,3,1]]},"reference":[{"key":"2025022705375708700_JOCES_17_2_307C1","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1242\/jcs.12.3.809","article-title":"Human chromosomes in 18 man-mouse somatic hybrid cell lines analysed by quinacrine fluorescence","volume":"12","year":"1973","journal-title":"J. Cell Sci."},{"key":"2025022705375708700_JOCES_17_2_307C2","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/0005-2787(71)90611-3","article-title":"Ribosomal RNA synthesis in human-mouse hybrid cells","volume":"232","year":"1971","journal-title":"Biochim. biophys. 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