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Here we found that clathrin, a vesicle coat protein, and clathrin adaptor protein complex 1 (AP-1) were present at REs and were needed for the retrograde transport of cholera toxin B subunit (CTxB) from REs to the Golgi, but not from the PM to REs. SMAP2 immunoprecipitated clathrin\/AP-1 through a putative clathrin-binding domain and a CALM-binding domain, and SMAP2 mutants that did not interact with clathrin\/AP-1 could not localize to REs. Moreover, knockdown of Arf1 suppressed the retrograde transport of CTxB from REs to the Golgi. These findings suggest a clathrin-coated-vesicles-mediated retrograde transport from REs and the role of the coat proteins in the recruitment of Arf GAP to transport vesicles.<\/jats:p>","DOI":"10.1242\/jcs.172171","type":"journal-article","created":{"date-parts":[[2015,7,2]],"date-time":"2015-07-02T02:31:11Z","timestamp":1435804271000},"source":"Crossref","is-referenced-by-count":21,"title":["Transport of cholera toxin B-subunit from recycling endosomes to the Golgi requires clathrin and AP-1"],"prefix":"10.1242","author":[{"given":"Tatsuyuki","family":"Matsudaira","sequence":"first","affiliation":[{"name":"Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo-ku, Tokyo, 113-0033, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Niki","sequence":"additional","affiliation":[{"name":"Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo-ku, Tokyo, 113-0033, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiko","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo-ku, Tokyo, 113-0033, Japan"},{"name":"Pathological Cell Biology Laboratory, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo-ku, Tokyo, 113-0033, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo-ku, Tokyo, 113-0033, Japan"},{"name":"Pathological Cell Biology Laboratory, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo-ku, Tokyo, 113-0033, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2015,1,1]]},"reference":[{"key":"2021042614392450100_JCS172171C1","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1002\/j.1460-2075.1988.tb02897.x","article-title":"Structural relationships between clathrin assembly proteins from the Golgi and the plasma membrane","volume":"7","author":"Ahle","year":"1988","journal-title":"EMBO J."},{"key":"2021042614392450100_JCS172171C2","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/ncb2034","article-title":"Protein complexes containing CYFIP\/Sra\/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN","volume":"12","author":"Anitei","year":"2010","journal-title":"Nat. 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