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Injection of the LRP1 ligands, tissue-type plasminogen activator (tPA) or MMP9-PEX, into crush-injured sciatic nerves, activated ERK1\/2 in SCs in vivo and the response was blocked by systemic treatment with the NMDA-R inhibitor, MK801. tPA was unique amongst the LRP1 ligands examined because tPA activated cell-signaling and promoted SC migration by interacting with the NMDA-R independently of LRP1, albeit with delayed kinetics. These results define the NMDA-R as a SC signaling receptor for protein ligands and a major regulator of SC physiology, which may be particularly important in PNS injury.<\/jats:p>","DOI":"10.1242\/jcs.173765","type":"journal-article","created":{"date-parts":[[2015,8,14]],"date-time":"2015-08-14T02:14:06Z","timestamp":1439518446000},"source":"Crossref","is-referenced-by-count":29,"title":["The NMDA receptor functions independently and as an LRP1 co-receptor to promote Schwann cell survival and migration"],"prefix":"10.1242","author":[{"given":"Elisabetta","family":"Mantuano","sequence":"first","affiliation":[{"name":"Department of Pathology, University of California San Diego, La Jolla CA, 92093, USA"},{"name":"Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of California San Diego, La Jolla CA, 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Shibayama","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University of California San Diego, La Jolla CA, 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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