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Expression analysis revealed that the periostin expressing cell population in the PNS corresponds to SC precursors and SCs and is particularly high in migratory SCs. Furthermore; stimulation of SCs with neuregulin\u20111 (NRG1) or transforming growth factor \u03b2 (TGF\u03b2) resulted in an upregulation of periostin expression. Interestingly, DRG explant cultures of periostin deficient mice revealed a significant reduction of the number of migrating SCs. These data demonstrate that the expression of periostin is stimulated by erbB ligand NRG1 and influences the migration of SC precursors.<\/jats:p>","DOI":"10.1242\/jcs.174177","type":"journal-article","created":{"date-parts":[[2015,7,18]],"date-time":"2015-07-18T01:34:36Z","timestamp":1437183276000},"source":"Crossref","is-referenced-by-count":15,"title":["Promotion of periostin expression contributes to the migration of Schwann cells"],"prefix":"10.1242","author":[{"given":"Eva","family":"Sonnenberg-Riethmacher","sequence":"first","affiliation":[{"name":"Human Genetics Division, University of Southampton, School of Medicine Tremona Road, SO16 6YD Southampton, UK"},{"name":"Center for Molecular Neurobiology, University of Hamburg, Falkenried 94, 20251 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Miehe","sequence":"additional","affiliation":[{"name":"Center for Molecular Neurobiology, University of Hamburg, Falkenried 94, 20251 Hamburg, Germany"},{"name":"Institut for Immunological Engineering, University of Aarhus, Gustav Wieds Vej 10, 8000 Aarhus C, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Riethmacher","sequence":"additional","affiliation":[{"name":"Human Genetics Division, University of Southampton, School of Medicine Tremona Road, SO16 6YD Southampton, UK"},{"name":"Center for Molecular Neurobiology, University of Hamburg, Falkenried 94, 20251 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2015,1,1]]},"reference":[{"key":"2021042614404962100_JCS174177C1","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/S1535-6108(04)00081-9","article-title":"Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt\/PKB pathway","volume":"5","author":"Bao","year":"2004","journal-title":"Cancer Cell"},{"key":"2021042614404962100_JCS174177C2","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/S0955-0674(02)00361-7","article-title":"Matricellular proteins: extracellular modulators of cell function","volume":"14","author":"Bornstein","year":"2002","journal-title":"Curr. 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