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Recent transcriptomic studies have shown that there is an upregulation in IGF1 expression in calvarial osteoblasts derived from patients with single-suture craniosynostosis (SSC). Upregulation of the IGF1 signaling pathway is known to induce increased expression of a set of osteogenic markers that previously have been shown to be correlated with contractility and migration. Although the IGF1 signaling pathway has been implicated in SSC, a correlation between IGF1, contractility and migration has not yet been investigated. Here, we examined the effect of IGF1 activation in inducing cellular contractility and migration in SSC osteoblasts using micropost arrays and time-lapse microscopy. We observed that the contractile forces and migration speeds of SSC osteoblasts correlated with IGF1 expression. Moreover, both contractility and migration of SSC osteoblasts were directly affected by the interaction of IGF1 with IGF1 receptor (IGF1R). Our results suggest that IGF1 activity can provide valuable insight for phenotype\u2013genotype correlation in SSC osteoblasts and might provide a target for therapeutic intervention.<\/jats:p>","DOI":"10.1242\/jcs.175976","type":"journal-article","created":{"date-parts":[[2015,12,12]],"date-time":"2015-12-12T03:08:37Z","timestamp":1449889717000},"page":"483-491","source":"Crossref","is-referenced-by-count":21,"title":["Activation of the IGF1 pathway mediates changes in cellular contractility and motility in single-suture craniosynostosis"],"prefix":"10.1242","volume":"129","author":[{"given":"Zeinab","family":"Al-Rekabi","sequence":"first","affiliation":[{"name":"University of Washington 1 Department of Mechanical Engineering , , Seattle, WA 98195 , USA"},{"name":"Seattle Children's Research Institute, Center for Developmental Biology and Regenerative Medicine 2 , Seattle, WA 98101 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marsha M.","family":"Wheeler","sequence":"additional","affiliation":[{"name":"University of Washington 3 Department of Genome Sciences , , Seattle, WA 98105 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Leonard","sequence":"additional","affiliation":[{"name":"University of Washington 1 Department of Mechanical Engineering , , Seattle, WA 98195 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriane M.","family":"Fura","sequence":"additional","affiliation":[{"name":"University of Washington 4 Department of Bioengineering , , Seattle, WA 98105 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilsa","family":"Juhlin","sequence":"additional","affiliation":[{"name":"University of Washington 1 Department of Mechanical Engineering , , Seattle, WA 98195 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Frazar","sequence":"additional","affiliation":[{"name":"University of Washington 3 Department of Genome Sciences , , Seattle, WA 98105 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua D.","family":"Smith","sequence":"additional","affiliation":[{"name":"University of Washington 3 Department of Genome Sciences , , Seattle, WA 98105 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah S.","family":"Park","sequence":"additional","affiliation":[{"name":"Seattle Children's Research Institute, Center for Developmental Biology and Regenerative Medicine 2 , Seattle, WA 98101 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer A.","family":"Gustafson","sequence":"additional","affiliation":[{"name":"Seattle Children's Research Institute, Center for Developmental Biology and Regenerative Medicine 2 , Seattle, WA 98101 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine M.","family":"Clarke","sequence":"additional","affiliation":[{"name":"Seattle Children's Research Institute, Center for Developmental Biology and Regenerative Medicine 2 , Seattle, WA 98101 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael L.","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Seattle Children's Research Institute, Center for Developmental Biology and Regenerative Medicine 2 , Seattle, WA 98101 , USA"},{"name":"University of Washington 5 Division of Craniofacial Medicine and the Department of Pediatrics , , Seattle, WA 98105 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan J.","family":"Sniadecki","sequence":"additional","affiliation":[{"name":"University of Washington 1 Department of Mechanical Engineering , , Seattle, WA 98195 , USA"},{"name":"University of Washington 4 Department of Bioengineering , , Seattle, WA 98105 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","reference":[{"key":"2024061316030718700_JCS175976C1","doi-asserted-by":"publisher","first-page":"066003","DOI":"10.1088\/1478-3975\/10\/6\/066003","article-title":"Cross talk between matrix elasticity and mechanical force regulates myoblast traction dynamics","volume":"10","author":"Al-Rekabi","year":"2013","journal-title":"Phys. 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