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Although these effects could very well involve p120's activity towards Rho, ascertaining the impact of this relationship has been complicated by the fact that p120 is also required for cell\u2013cell adhesion. Here, we have molecularly uncoupled p120's cadherin-stabilizing and RhoA-suppressing activites. Unexpectedly, removing p120's Rho-suppressing activity dramatically disrupted the integrity of the apical surface, irrespective of E-cadherin stability. The physical defect was tracked to excessive actomyosin contractility along the vertical axis of lateral membranes. Thus, we suggest that p120's distinct activities towards E-cadherin and Rho are molecularly and functionally coupled and this, in turn, enables the maintenance of cell shape in the larger context of an epithelial monolayer. Importantly, local suppression of contractility by cadherin-bound p120 appears to go beyond regulating cell shape, as loss of this activity also leads to major defects in epithelial lumenogenesis.<\/jats:p>","DOI":"10.1242\/jcs.177550","type":"journal-article","created":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T20:02:23Z","timestamp":1450382543000},"page":"80-94","source":"Crossref","is-referenced-by-count":38,"title":["p120-catenin controls contractility along the vertical axis of epithelial lateral membranes"],"prefix":"10.1242","volume":"129","author":[{"given":"Huapeng H.","family":"Yu","sequence":"first","affiliation":[{"name":"Vanderbilt University 1 Department of Cancer Biology , , 37232 Nashville, TN , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Dohn","sequence":"additional","affiliation":[{"name":"Vanderbilt University 1 Department of Cancer Biology , , 37232 Nashville, TN , USA"},{"name":"Vanderbilt University 2 Department of Pharmacology , , 37232 Nashville, TN , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas O.","family":"Markham","sequence":"additional","affiliation":[{"name":"Vanderbilt University 1 Department of Cancer Biology , , 37232 Nashville, TN , USA"},{"name":"School of Medicine, Vanderbilt University 3 , 37232 Nashville, TN , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Coffey","sequence":"additional","affiliation":[{"name":"School of Medicine, Vanderbilt University 3 , 37232 Nashville, TN , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert B.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Vanderbilt University 1 Department of Cancer Biology , , 37232 Nashville, TN , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2024061316012991700_JCS177550C1","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/S0955-0674(00)00258-1","article-title":"Regulation of Rho GTPases by p120-catenin","volume":"13","author":"Anastasiadis","year":"2001","journal-title":"Curr. 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