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Although nuclear import rates generally positively correlate with nuclear size, NTF2 levels negatively affect nuclear size, despite the role of NTF2 (also known as NUTF2) in nuclear recycling of the import factor Ran. We show that binding of Ran to NTF2 is required for NTF2 to inhibit nuclear expansion and import of large cargo molecules in Xenopus laevis egg and embryo extracts, consistent with our observation that NTF2 reduces the diameter of the nuclear pore complex (NPC) in a Ran-binding-dependent manner. Furthermore, we demonstrate that ectopic NTF2 expression in Xenopus embryos and mammalian tissue culture cells alters nuclear size. Finally, we show that increases in nuclear size during melanoma progression correlate with reduced NTF2 expression, and increasing NTF2 levels in melanoma cells is sufficient to reduce nuclear size. These results show a conserved capacity for NTF2 to impact on nuclear size, and we propose that NTF2 might be a new cancer biomarker.<\/jats:p>","DOI":"10.1242\/jcs.181263","type":"journal-article","created":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T03:04:08Z","timestamp":1454036648000},"page":"1115-1127","source":"Crossref","is-referenced-by-count":48,"title":["Nuclear size is sensitive to NTF2 protein levels in a manner dependent on Ran binding"],"prefix":"10.1242","volume":"129","author":[{"given":"Lidija D.","family":"Vukovi\u0107","sequence":"first","affiliation":[{"name":"University of Wyoming 1 Department of Molecular Biology , , Laramie, WY 82071 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Predrag","family":"Jevti\u0107","sequence":"additional","affiliation":[{"name":"University of Wyoming 1 Department of Molecular Biology , , Laramie, WY 82071 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaojie","family":"Zhang","sequence":"additional","affiliation":[{"name":"University of Wyoming 2 Department of Zoology and Physiology , , Laramie, WY 82071 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley A.","family":"Stohr","sequence":"additional","affiliation":[{"name":"University of California 3 Department of Pathology , , San Francisco, CA 94143 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L.","family":"Levy","sequence":"additional","affiliation":[{"name":"University of Wyoming 1 Department of Molecular Biology , , Laramie, WY 82071 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2024061316062116000_JCS181263C1","first-page":"1771","article-title":"Correlation of nuclear morphometry of breast cancer in histological sections with clinicopathological features and prognosis","volume":"29","author":"Abdalla","year":"2009","journal-title":"Anticancer Res."},{"key":"2024061316062116000_JCS181263C2","doi-asserted-by":"publisher","first-page":"8462","DOI":"10.1074\/jbc.M709572200","article-title":"Regulation of nuclear lamin polymerization by importin alpha","volume":"283","author":"Adam","year":"2008","journal-title":"J. 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