{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:10:31Z","timestamp":1790687431443,"version":"4.1.0"},"reference-count":58,"publisher":"The Company of Biologists","issue":"12","license":[{"start":{"date-parts":[[2016,12,15]],"date-time":"2016-12-15T00:00:00Z","timestamp":1481760000000},"content-version":"vor","delay-in-days":183,"URL":"http:\/\/www.biologists.com\/user-licence-1-1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM111557"],"award-info":[{"award-number":["GM111557"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM110155"],"award-info":[{"award-number":["GM110155"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA163896"],"award-info":[{"award-number":["CA163896"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM093208"],"award-info":[{"award-number":["GM093208"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,6,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Haptotaxis is the process by which cells respond to gradients of substrate-bound cues, such as extracellular matrix proteins (ECM); however, the cellular mechanism of this response remains poorly understood and has mainly been studied by comparing cell behavior on uniform ECMs with different concentrations of components. To study haptotaxis in response to gradients, we utilized microfluidic chambers to generate gradients of the ECM protein fibronectin, and imaged the cell migration response. Lamellipodia are fan-shaped protrusions that are common in migrating cells. Here, we define a new function for lamellipodia and the cellular mechanism required for haptotaxis \u2013 differential actin and lamellipodial protrusion dynamics lead to biased cell migration. Modest differences in lamellipodial dynamics occurring over time periods of seconds to minutes are summed over hours to produce differential whole cell movement towards higher concentrations of fibronectin. We identify a specific subset of lamellipodia regulators as being crucial for haptotaxis. Numerous studies have linked components of this pathway to cancer metastasis and, consistent with this, we find that expression of the oncogenic Rac1 P29S mutation abrogates haptotaxis. Finally, we show that haptotaxis also operates through this pathway in 3D environments.<\/jats:p>","DOI":"10.1242\/jcs.184507","type":"journal-article","created":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T21:54:17Z","timestamp":1463090057000},"page":"2329-2342","source":"Crossref","is-referenced-by-count":93,"title":["Lamellipodia are crucial for haptotactic sensing and response"],"prefix":"10.1242","volume":"129","author":[{"given":"Samantha J.","family":"King","sequence":"first","affiliation":[{"name":"UNC Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill 1 , Chapel Hill, NC 27514 , USA"},{"name":"The University of North Carolina at Chapel Hill 2 Department of Cell Biology and Physiology , , Chapel Hill, NC 27599 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreeja B.","family":"Asokan","sequence":"additional","affiliation":[{"name":"UNC Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill 1 , Chapel Hill, NC 27514 , USA"},{"name":"The University of North Carolina at Chapel Hill 2 Department of Cell Biology and Physiology , , Chapel Hill, NC 27599 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"Haynes","sequence":"additional","affiliation":[{"name":"UNC Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill 1 , Chapel Hill, NC 27514 , USA"},{"name":"The University of North Carolina at Chapel Hill 2 Department of Cell Biology and Physiology , , Chapel Hill, NC 27599 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth P.","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"UNC Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill 1 , Chapel Hill, NC 27514 , USA"},{"name":"University of North Carolina 3 Department of Biochemistry and Biophysics , , Chapel Hill, NC 27599 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy D.","family":"Rotty","sequence":"additional","affiliation":[{"name":"UNC Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill 1 , Chapel Hill, NC 27514 , USA"},{"name":"The University of North Carolina at Chapel Hill 2 Department of Cell Biology and Physiology , , Chapel Hill, NC 27599 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"James G.","family":"Alb","sequence":"additional","affiliation":[{"name":"UNC Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill 1 , Chapel Hill, NC 27514 , USA"},{"name":"The University of North Carolina at Chapel Hill 2 Department of Cell Biology and Physiology , , Chapel Hill, NC 27599 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Tagliatela","sequence":"additional","affiliation":[{"name":"UNC Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill 1 , Chapel Hill, NC 27514 , USA"},{"name":"The University of North Carolina at Chapel Hill 2 Department of Cell Biology and Physiology , , Chapel Hill, NC 27599 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devon R.","family":"Blake","sequence":"additional","affiliation":[{"name":"UNC Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill 1 , Chapel Hill, NC 27514 , USA"},{"name":"University of North Carolina at Chapel Hill, School of Medicine 4 Department of Pharmacology , , Chapel Hill, NC 27599 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina P.","family":"Lebedeva","sequence":"additional","affiliation":[{"name":"UNC Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill 1 , Chapel Hill, NC 27514 , USA"},{"name":"Howard Hughes Medical Institute, The University of North Carolina at Chapel Hill 5 , Chapel Hill, NC 27599 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Marston","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill, School of Medicine 4 Department of Pharmacology , , Chapel Hill, NC 27599 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heath E.","family":"Johnson","sequence":"additional","affiliation":[{"name":"North Carolina State University 6 Department of Chemical & Biomolecular Engineering , , Raleigh, NC 27695 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maddy","family":"Parsons","sequence":"additional","affiliation":[{"name":"King's College London, Randall Institute 7 , London SE1 8RT , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman E.","family":"Sharpless","sequence":"additional","affiliation":[{"name":"UNC Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill 1 , Chapel Hill, NC 27514 , USA"},{"name":"The University of North Carolina at Chapel Hill 8 Department of Genetics , , Chapel Hill, NC 27599 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Kuhlman","sequence":"additional","affiliation":[{"name":"UNC Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill 1 , Chapel Hill, NC 27514 , USA"},{"name":"University of North Carolina 3 Department of Biochemistry and Biophysics , , Chapel Hill, NC 27599 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason M.","family":"Haugh","sequence":"additional","affiliation":[{"name":"North Carolina State University 6 Department of Chemical & Biomolecular Engineering , , Raleigh, NC 27695 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8489-996X","authenticated-orcid":false,"given":"James E.","family":"Bear","sequence":"additional","affiliation":[{"name":"UNC Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill 1 , Chapel Hill, NC 27514 , USA"},{"name":"The University of North Carolina at Chapel Hill 2 Department of Cell Biology and Physiology , , Chapel Hill, NC 27599 , USA"},{"name":"Howard Hughes Medical Institute, The University of North Carolina at Chapel Hill 5 , Chapel Hill, NC 27599 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2024061316164298000_JCS184507C1","doi-asserted-by":"publisher","first-page":"159","DOI":"10.4161\/sgtp.26530","article-title":"Mutationally activated Rho GTPases in cancer","volume":"4","author":"Alan","year":"2013","journal-title":"Small GTPases"},{"key":"2024061316164298000_JCS184507C2","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1002\/cm.20101","article-title":"Src-dependent phosphorylation of Scar1 promotes its association with the Arp2\/3 complex","volume":"63","author":"Ardern","year":"2006","journal-title":"Cell Motil. Cytoskeleton"},{"key":"2024061316164298000_JCS184507C3","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.devcel.2014.10.024","article-title":"Mesenchymal chemotaxis requires selective inactivation of myosin II at the leading edge via a noncanonical PLCgamma\/PKCalpha pathway","volume":"31","author":"Asokan","year":"2014","journal-title":"Dev. Cell"},{"key":"2024061316164298000_JCS184507C4","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1083\/jcb.110.4.1427","article-title":"Signal transduction for chemotaxis and haptotaxis by matrix molecules in tumor cells","volume":"110","author":"Aznavoorian","year":"1990","journal-title":"J. Cell Biol."},{"key":"2024061316164298000_JCS184507C5","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1016\/j.cub.2014.07.011","article-title":"Integrin-associated complexes form hierarchically with variable stoichiometry in nascent adhesions","volume":"24","author":"Bachir","year":"2014","journal-title":"Curr. Biol."},{"key":"2024061316164298000_JCS184507C6","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.ceb.2014.06.005","article-title":"Directed migration of mesenchymal cells: where signaling and the cytoskeleton meet","volume":"30","author":"Bear","year":"2014","journal-title":"Curr. Opin. Cell Biol."},{"key":"2024061316164298000_JCS184507C7","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/S0092-8674(02)00731-6","article-title":"Antagonism between Ena\/VASP proteins and actin filament capping regulates fibroblast motility","volume":"109","author":"Bear","year":"2002","journal-title":"Cell"},{"key":"2024061316164298000_JCS184507C8","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.cellsig.2013.11.034","article-title":"The guanine nucleotide exchange factor Tiam1: a Janus-faced molecule in cellular signaling","volume":"26","author":"Boissier","year":"2014","journal-title":"Cell. Signal."},{"key":"2024061316164298000_JCS184507C9","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1016\/j.cell.2008.06.054","article-title":"Coronin 1B antagonizes cortactin and remodels Arp2\/3-containing actin branches in lamellipodia","volume":"134","author":"Cai","year":"2008","journal-title":"Cell"},{"key":"2024061316164298000_JCS184507C10","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/nrm2867","article-title":"A nucleator arms race: cellular control of actin assembly","volume":"11","author":"Campellone","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2024061316164298000_JCS184507C11","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1038\/2081183a0","article-title":"Principles of cell motility: the direction of cell movement and cancer invasion","volume":"208","author":"Carter","year":"1965","journal-title":"Nature"},{"key":"2024061316164298000_JCS184507C12","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1038\/220970a0","article-title":"Tissue homeostasis and the biological basis of cancer","volume":"220","author":"Carter","year":"1968","journal-title":"Nature"},{"key":"2024061316164298000_JCS184507C13","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1083\/jcb.201404067","article-title":"LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues","volume":"207","author":"Chan","year":"2014","journal-title":"J. Cell Biol."},{"key":"2024061316164298000_JCS184507C14","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1038\/nature09623","article-title":"Structure and control of the actin regulatory WAVE complex","volume":"468","author":"Chen","year":"2010","journal-title":"Nature"},{"key":"2024061316164298000_JCS184507C15","doi-asserted-by":"publisher","first-page":"128s","DOI":"10.1111\/1523-1747.ep12876104","article-title":"Fibronectin matrix deposition and fibronectin receptor expression in healing and normal skin","volume":"94","author":"Clark","year":"1990","journal-title":"J. Invest. Dermatol."},{"key":"2024061316164298000_JCS184507C16","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1073\/pnas.1220895110","article-title":"RAC1P29S is a spontaneously activating cancer-associated GTPase","volume":"110","author":"Davis","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024061316164298000_JCS184507C17","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nrc2748","article-title":"Integrins in cancer: biological implications and therapeutic opportunities","volume":"10","author":"Desgrosellier","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"2024061316164298000_JCS184507C18","doi-asserted-by":"publisher","first-page":"7618","DOI":"10.1073\/pnas.0307512101","article-title":"Rational design and characterization of a Rac GTPase-specific small molecule inhibitor","volume":"101","author":"Gao","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024061316164298000_JCS184507C19","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1073\/pnas.1417910112","article-title":"Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins","volume":"112","author":"Guntas","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024061316164298000_JCS184507C20","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.clinthera.2014.10.027","article-title":"RAC1 and melanoma","volume":"37","author":"Halaban","year":"2015","journal-title":"Clin. Ther."},{"key":"2024061316164298000_JCS184507C21","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1074\/jbc.271.2.695","article-title":"Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor: study of Lck- and FynT-dependent T cell activation","volume":"271","author":"Hanke","year":"1996","journal-title":"J. Biol. Chem."},{"key":"2024061316164298000_JCS184507C22","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1083\/jcb.201501094","article-title":"GMFbeta controls branched actin content and lamellipodial retraction in fibroblasts","volume":"209","author":"Haynes","year":"2015","journal-title":"J. Cell Biol."},{"key":"2024061316164298000_JCS184507C23","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/S0092-8674(02)00971-6","article-title":"Integrins: bidirectional, allosteric signaling machines","volume":"110","author":"Hynes","year":"2002","journal-title":"Cell"},{"key":"2024061316164298000_JCS184507C24","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1083\/jcb.201406102","article-title":"F-actin bundles direct the initiation and orientation of lamellipodia through adhesion-based signaling","volume":"208","author":"Johnson","year":"2015","journal-title":"J. Cell Biol."},{"key":"2024061316164298000_JCS184507C25","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1038\/emboj.2011.82","article-title":"beta1 integrins regulate fibroblast chemotaxis through control of N-WASP stability","volume":"30","author":"King","year":"2011","journal-title":"EMBO J."},{"key":"2024061316164298000_JCS184507C26","doi-asserted-by":"publisher","first-page":"2459","DOI":"10.1093\/emboj\/18.9.2459","article-title":"Src family kinases are required for integrin but not PDGFR signal transduction","volume":"18","author":"Klinghoffer","year":"1999","journal-title":"EMBO J."},{"key":"2024061316164298000_JCS184507C27","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1074\/jbc.273.1.291","article-title":"p140Sra-1 (Specifically Rac1-associated Protein) is a novel specific target for Rac1 small GTPase","volume":"273","author":"Kobayashi","year":"1998","journal-title":"J. Biol. Chem."},{"key":"2024061316164298000_JCS184507C28","doi-asserted-by":"publisher","first-page":"2403","DOI":"10.1016\/j.bbagen.2014.02.018","article-title":"Non-collagenous ECM proteins in blood vessel morphogenesis and cancer","volume":"1840","author":"Kostourou","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"2024061316164298000_JCS184507C29","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1038\/ng.2359","article-title":"Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma","volume":"44","author":"Krauthammer","year":"2012","journal-title":"Nat. Genet."},{"key":"2024061316164298000_JCS184507C30","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1038\/ncb2216","article-title":"Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for beta-Pix in negative regulation of focal adhesion maturation","volume":"13","author":"Kuo","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"2024061316164298000_JCS184507C31","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1038\/ncb3026","article-title":"An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration","volume":"16","author":"Kutys","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"2024061316164298000_JCS184507C32","doi-asserted-by":"publisher","first-page":"e27958","DOI":"10.4161\/sgtp.27958","article-title":"The on-off relationship of Rho and Rac during integrin-mediated adhesion and cell migration","volume":"5","author":"Lawson","year":"2014","journal-title":"Small GTPases"},{"key":"2024061316164298000_JCS184507C33","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1111\/pcmr.12295","article-title":"Clinical and pathological associations of the activating RAC1 P29S mutation in primary cutaneous melanoma","volume":"27","author":"Mar","year":"2014","journal-title":"Pigment Cell Melanoma Res."},{"key":"2024061316164298000_JCS184507C34","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.ceb.2006.08.011","article-title":"Integrin-regulated FAK-Src signaling in normal and cancer cells","volume":"18","author":"Mitra","year":"2006","journal-title":"Curr. Opin. Cell Biol."},{"key":"2024061316164298000_JCS184507C35","doi-asserted-by":"publisher","first-page":"2730","DOI":"10.1128\/MCB.01285-08","article-title":"Cdc42 and Rac family GTPases regulate mode and speed but not direction of primary fibroblast migration during platelet-derived growth factor-dependent chemotaxis","volume":"29","author":"Monypenny","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"2024061316164298000_JCS184507C36","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.2174\/156802606777812095","article-title":"Structure-function based design of small molecule inhibitors targeting Rho family GTPases","volume":"6","author":"Nassar","year":"2006","journal-title":"Curr. Top. Med. Chem."},{"key":"2024061316164298000_JCS184507C37","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1242\/jcs.018440","article-title":"Quantification of integrin receptor agonism by fluorescence lifetime imaging","volume":"121","author":"Parsons","year":"2008","journal-title":"J. Cell Sci."},{"key":"2024061316164298000_JCS184507C38","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1146\/annurev.biophys.35.040405.101936","article-title":"Regulation of actin filament assembly by Arp2\/3 complex and formins","volume":"36","author":"Pollard","year":"2007","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"2024061316164298000_JCS184507C39","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1126\/science.1092053","article-title":"Cell migration: integrating signals from front to back","volume":"302","author":"Ridley","year":"2003","journal-title":"Science"},{"key":"2024061316164298000_JCS184507C40","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.ejcb.2005.10.007","article-title":"AlphaPIX and betaPIX and their role in focal adhesion formation","volume":"85","author":"Rosenberger","year":"2006","journal-title":"Eur. J. Cell Biol."},{"key":"2024061316164298000_JCS184507C41","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/S0960-9822(99)80286-3","article-title":"Interplay between Rac and Rho in the control of substrate contact dynamics","volume":"9","author":"Rottner","year":"1999","journal-title":"Curr. Biol."},{"key":"2024061316164298000_JCS184507C42","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/nrm3492","article-title":"New insights into the regulation and cellular functions of the ARP2\/3 complex","volume":"14","author":"Rotty","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2024061316164298000_JCS184507C43","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.devcel.2014.10.026","article-title":"Profilin-1 serves as a gatekeeper for actin assembly by Arp2\/3-dependent and -independent pathways","volume":"32","author":"Rotty","year":"2015","journal-title":"Dev. Cell"},{"key":"2024061316164298000_JCS184507C44","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1089\/wound.2014.0616","article-title":"Fibronectin interaction and enhancement of growth factors: importance for wound healing","volume":"4","author":"Sawicka","year":"2015","journal-title":"Adv. Wound Care"},{"key":"2024061316164298000_JCS184507C45","doi-asserted-by":"publisher","first-page":"a003228","DOI":"10.1101\/cshperspect.a003228","article-title":"Mammary gland ECM remodeling, stiffness, and mechanosignaling in normal development and tumor progression","volume":"3","author":"Schedin","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"2024061316164298000_JCS184507C46","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1038\/ncb1626","article-title":"Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2\/3 complex","volume":"9","author":"Serrels","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"2024061316164298000_JCS184507C47","doi-asserted-by":"publisher","first-page":"34339","DOI":"10.1074\/jbc.M302960200","article-title":"Rac1 function is required for Src-induced transformation: evidence of a role for Tiam1 and Vav2 in Rac activation by Src","volume":"278","author":"Servitja","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2024061316164298000_JCS184507C48","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/j.cell.2009.04.013","article-title":"Cyfip1 is a putative invasion suppressor in epithelial cancers","volume":"137","author":"Silva","year":"2009","journal-title":"Cell"},{"key":"2024061316164298000_JCS184507C49","doi-asserted-by":"publisher","first-page":"14845","DOI":"10.1074\/jbc.M606695200","article-title":"Cellular characterization of a novel focal adhesion kinase inhibitor","volume":"282","author":"Slack-Davis","year":"2007","journal-title":"J. Biol. Chem."},{"key":"2024061316164298000_JCS184507C50","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1091\/mbc.E15-08-0590","article-title":"The FAK-Arp2\/3 interaction promotes leading edge advance and haptosensing by coupling nascent adhesions to lamellipodia actin","volume":"27","author":"Swaminathan","year":"2016","journal-title":"Mol. Biol. Cell"},{"key":"2024061316164298000_JCS184507C51","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1002\/cphy.c140045","article-title":"Extracellular matrix communication and turnover in cardiac physiology and pathology","volume":"5","author":"Takawale","year":"2015","journal-title":"Compr. Physiol."},{"key":"2024061316164298000_JCS184507C52","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.cub.2012.11.059","article-title":"Loss of Scar\/WAVE complex promotes N-WASP- and FAK-dependent invasion","volume":"23","author":"Tang","year":"2013","journal-title":"Curr. Biol."},{"key":"2024061316164298000_JCS184507C53","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1083\/jcb.201202041","article-title":"Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration","volume":"199","author":"Wang","year":"2012","journal-title":"J. Cell Biol."},{"key":"2024061316164298000_JCS184507C54","doi-asserted-by":"publisher","first-page":"E97","DOI":"10.1038\/ncb0402-e97","article-title":"Adhesion assembly, disassembly and turnover in migrating cells -- over and over and over again","volume":"4","author":"Webb","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"2024061316164298000_JCS184507C55","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1126\/science.1228456","article-title":"Interstitial dendritic cell guidance by haptotactic chemokine gradients","volume":"339","author":"Weber","year":"2013","journal-title":"Science"},{"key":"2024061316164298000_JCS184507C56","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/j.tcb.2011.09.006","article-title":"Extracellular matrix determinants of proteolytic and non-proteolytic cell migration","volume":"21","author":"Wolf","year":"2011","journal-title":"Trends Cell Biol."},{"key":"2024061316164298000_JCS184507C57","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1083\/jcb.200912014","article-title":"Alpha v beta3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration","volume":"189","author":"Worth","year":"2010","journal-title":"J. Cell Biol."},{"key":"2024061316164298000_JCS184507C58","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/j.cell.2011.12.034","article-title":"Arp2\/3 is critical for lamellipodia and response to extracellular matrix cues but is dispensable for chemotaxis","volume":"148","author":"Wu","year":"2012","journal-title":"Cell"}],"container-title":["Journal of Cell Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1242\/jcs.184507","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/jcs\/article-pdf\/129\/12\/2329\/3494917\/jcs184507.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/jcs\/article-pdf\/doi\/10.1242\/jcs.184507\/2049728\/jcs_184507v1.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/jcs\/article-pdf\/129\/12\/2329\/3494917\/jcs184507.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T12:22:15Z","timestamp":1718281335000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/jcs\/article\/129\/12\/2329\/55641\/Lamellipodia-are-crucial-for-haptotactic-sensing"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,15]]},"references-count":58,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,6,15]]}},"URL":"https:\/\/doi.org\/10.1242\/jcs.184507","relation":{},"ISSN":["1477-9137","0021-9533"],"issn-type":[{"value":"1477-9137","type":"electronic"},{"value":"0021-9533","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6,15]]}}}