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Atlastin 1 (ATL1, also known as SPG3A) encodes an ER membrane fusion GTPase and reticulon 2 (RTN2, also known as SPG12) helps shape ER tube formation. Here, we use a new fluorescent ER marker to show that the ER within wild-type Drosophila motor nerve terminals forms a network of tubules that is fragmented and made diffuse upon loss of the atlastin 1 ortholog atl. atl or Rtnl1 loss decreases evoked transmitter release and increases arborization. Similar to other HSP proteins, Atl inhibits bone morphogenetic protein (BMP) signaling, and loss of atl causes age-dependent locomotor deficits in adults. These results demonstrate a crucial role for ER in neuronal function, and identify mechanistic links between ER morphology, neuronal function, BMP signaling and adult behavior.<\/jats:p>","DOI":"10.1242\/jcs.184929","type":"journal-article","created":{"date-parts":[[2016,2,24]],"date-time":"2016-02-24T04:00:15Z","timestamp":1456286415000},"page":"1635-1648","source":"Crossref","is-referenced-by-count":85,"title":["The effects of ER morphology on synaptic structure and function in <i>Drosophila melanogaster<\/i>"],"prefix":"10.1242","volume":"129","author":[{"given":"James B.","family":"Summerville","sequence":"first","affiliation":[{"name":"Rice University 1 Department of BioSciences, Program in Biochemistry and Cell Biology , , Houston, TX 77005 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph F.","family":"Faust","sequence":"additional","affiliation":[{"name":"Rice University 1 Department of BioSciences, Program in Biochemistry and Cell Biology , , Houston, TX 77005 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan","family":"Fan","sequence":"additional","affiliation":[{"name":"Rice University 1 Department of BioSciences, Program in Biochemistry and Cell Biology , , Houston, TX 77005 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Pendin","sequence":"additional","affiliation":[{"name":"CNR, Neuroscience Institute 2 , 35121 Padova , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Daga","sequence":"additional","affiliation":[{"name":"E. 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