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The Rac1 GTPase controls actin polymerization at protrusions by interacting with its effector, the Wave regulatory complex (WRC). The exocyst complex, which functions in polarized exocytosis, has been involved in the regulation of cell motility. Here, we show a physical and functional connection between exocyst and WRC. Purified components of exocyst and WRC directly associate in vitro, and interactions interfaces are identified. The exocyst\u2013WRC interaction is confirmed in cells by co-immunoprecipitation and is shown to occur independently of the Arp2\/3 complex. Disruption of the exocyst\u2013WRC interaction leads to impaired migration. By using time-lapse microscopy coupled to image correlation analysis, we visualized the trafficking of the WRC towards the front of the cell in nascent protrusions. The exocyst is necessary for WRC recruitment at the leading edge and for resulting cell edge movements. This direct link between the exocyst and WRC provides a new mechanistic insight into the spatio-temporal regulation of cell migration.<\/jats:p>","DOI":"10.1242\/jcs.187336","type":"journal-article","created":{"date-parts":[[2016,9,3]],"date-time":"2016-09-03T02:09:05Z","timestamp":1472868545000},"page":"3756-3769","source":"Crossref","is-referenced-by-count":24,"title":["Direct interaction between exocyst and Wave complexes promotes cell protrusions and motility"],"prefix":"10.1242","volume":"129","author":[{"given":"Marco","family":"Biondini","sequence":"first","affiliation":[{"name":"Institut Curie, Centre de Recherche, Paris Sciences et Lettres Research University 1 , Paris 75005 , France"},{"name":"ART group, Inserm U830 2 , Paris 75005 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amel","family":"Sadou-Dubourgnoux","sequence":"additional","affiliation":[{"name":"Institut Curie, Centre de Recherche, Paris Sciences et Lettres Research University 1 , Paris 75005 , France"},{"name":"ART group, Inserm U830 2 , Paris 75005 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perrine","family":"Paul-Gilloteaux","sequence":"additional","affiliation":[{"name":"Institut Curie, Centre de Recherche, Paris Sciences et Lettres Research University 1 , Paris 75005 , France"},{"name":"CNRS UMR 144 3 Cell and Tissue Imaging Facility (PICT-IBiSA) , , Paris 75005 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Zago","sequence":"additional","affiliation":[{"name":"Institut Curie, Centre de Recherche, Paris Sciences et Lettres Research University 1 , Paris 75005 , France"},{"name":"ART group, Inserm U830 2 , Paris 75005 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melis D.","family":"Arslanhan","sequence":"additional","affiliation":[{"name":"Institut Curie, Centre de Recherche, Paris Sciences et Lettres Research University 1 , Paris 75005 , France"},{"name":"ART group, Inserm U830 2 , Paris 75005 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Waharte","sequence":"additional","affiliation":[{"name":"Institut Curie, Centre de Recherche, Paris Sciences et Lettres Research University 1 , Paris 75005 , France"},{"name":"CNRS UMR 144 3 Cell and Tissue Imaging Facility (PICT-IBiSA) , , Paris 75005 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Formstecher","sequence":"additional","affiliation":[{"name":"Hybrigenics 4 , Paris 75014 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maud","family":"Hertzog","sequence":"additional","affiliation":[{"name":"CNRS UMR 5100, Universit\u00e9 Paul Sabatier 5 Laboratoire de Microbiologie et G\u00e9n\u00e9tique Mol\u00e9culaire , , Toulouse 31062 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinchao","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, University Paris-Saclay, CEA-Saclay 6 , Gif-sur-Yvette 91191"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Guerois","sequence":"additional","affiliation":[{"name":"Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, University Paris-Saclay, CEA-Saclay 6 , Gif-sur-Yvette 91191"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Gautreau","sequence":"additional","affiliation":[{"name":"CNRS UMR7654 7 Laboratoire de Biochimie Ecole Polytechnique , , Palaiseau Cedex 91128 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Scita","sequence":"additional","affiliation":[{"name":"IFOM, Fondazione Istituto FIRC di Oncologia Molecolare and Dipartimento di Scienze della Salute, Universit\u00e0 degli Studi di Milano 8 , Milan 20139 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Camonis","sequence":"additional","affiliation":[{"name":"Institut Curie, Centre de Recherche, Paris Sciences et Lettres Research University 1 , Paris 75005 , France"},{"name":"ART group, Inserm U830 2 , Paris 75005 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7082-9792","authenticated-orcid":false,"given":"Maria Carla","family":"Parrini","sequence":"additional","affiliation":[{"name":"Institut Curie, Centre de Recherche, Paris Sciences et Lettres Research University 1 , Paris 75005 , France"},{"name":"ART group, Inserm U830 2 , Paris 75005 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2024061316275438900_JCS187336C1","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/ncb3286","article-title":"Isoform diversity in the Arp2\/3 complex determines actin filament dynamics","volume":"18","author":"Abella","year":"2016","journal-title":"Nat. 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