{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:45:28Z","timestamp":1768092328822,"version":"3.49.0"},"reference-count":56,"publisher":"The Company of Biologists","issue":"4","license":[{"start":{"date-parts":[[2017,8,15]],"date-time":"2017-08-15T00:00:00Z","timestamp":1502755200000},"content-version":"vor","delay-in-days":181,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01HL77806"],"award-info":[{"award-number":["P01HL77806"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Saiseikai Otaru Hospital"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,2,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Acidification of macrophage phagosomes serves an important bactericidal function. We show here that the redox-sensitive transient receptor potential (TRP) cation channel TRPM2 is expressed in the phagosomal membrane and regulates macrophage bactericidal activity through the activation of phagosomal acidification. Measurement of the TRPM2 current in phagosomes identified TRPM2 as a functional redox-sensitive cation channel localized in the phagosomal membrane. Simultaneous measurements of phagosomal Ca2+ changes and phagosome acidification in macrophages undergoing phagocytosis demonstrated that TRPM2 was required to mediate the efflux of cations and for phagosomal acidification during the process of phagosome maturation. Acidification in phagosomes was significantly reduced in macrophages isolated from Trpm2\u2212\/\u2212 mice as compared to wild type, and acidification was coupled to reduced bacterial clearance in Trpm2\u2212\/\u2212 mice. Trpm2+\/+ macrophages treated with the vacuolar H+-ATPase inhibitor bafilomycin showed reduced bacterial clearance, similar to that in Trpm2\u2212\/\u2212 macrophages. Direct activation of TRPM2 using adenosine diphosphate ribose (ADPR) induced both phagosomal acidification and bacterial killing. These data collectively demonstrate that TRPM2 regulates phagosomal acidification, and is essential for the bacterial killing function of macrophages.<\/jats:p>","DOI":"10.1242\/jcs.196014","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T01:45:38Z","timestamp":1484271938000},"page":"735-744","source":"Crossref","is-referenced-by-count":44,"title":["Role of the phagosomal redox-sensitive TRP channel TRPM2 in regulating bactericidal activity of macrophages"],"prefix":"10.1242","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5055-1407","authenticated-orcid":false,"given":"Anke","family":"Di","sequence":"first","affiliation":[{"name":"The University of Illinois College of Medicine Department of Pharmacology and the Center for Lung and Vascular Biology , , Chicago, IL 60612 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0027-7758","authenticated-orcid":false,"given":"Tomohiro","family":"Kiya","sequence":"additional","affiliation":[{"name":"The University of Illinois College of Medicine Department of Pharmacology and the Center for Lung and Vascular Biology , , Chicago, IL 60612 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haixia","family":"Gong","sequence":"additional","affiliation":[{"name":"The University of Illinois College of Medicine Department of Pharmacology and the Center for Lung and Vascular Biology , , Chicago, IL 60612 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaopei","family":"Gao","sequence":"additional","affiliation":[{"name":"The University of Illinois College of Medicine Department of Pharmacology and the Center for Lung and Vascular Biology , , Chicago, IL 60612 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8205-7128","authenticated-orcid":false,"given":"Asrar B.","family":"Malik","sequence":"additional","affiliation":[{"name":"The University of Illinois College of Medicine Department of Pharmacology and the Center for Lung and Vascular Biology , , Chicago, IL 60612 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","reference":[{"key":"2024061316360510000_JCS196014C1","doi-asserted-by":"publisher","first-page":"2967","DOI":"10.1523\/JNEUROSCI.5552-09.2010","article-title":"NAD+ depletion is necessary and sufficient for poly(ADP-ribose) polymerase-1-mediated neuronal death","volume":"30","author":"Alano","year":"2010","journal-title":"J. Neurosci."},{"key":"2024061316360510000_JCS196014C2","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1023\/B:BIRE.0000037755.42767.a4","article-title":"NAD glycohydrolase activities and ADP-ribose uptake in erythrocytes from normal subjects and cancer patients","volume":"24","author":"Albeniz","year":"2004","journal-title":"Biosci. Rep."},{"key":"2024061316360510000_JCS196014C3","doi-asserted-by":"crossref","first-page":"4564","DOI":"10.1016\/S0021-9258(18)93229-1","article-title":"Digestive activity of lysosomes. II. The digestion of macromolecular carbohydrates by extracts of rat liver lysosomes","volume":"243","author":"Aronson","year":"1968","journal-title":"J. Biol. Chem."},{"key":"2024061316360510000_JCS196014C4","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1046\/j.1365-2958.2002.02876.x","article-title":"NAD+-glycohydrolase acts as an intracellular toxin to enhance the extracellular survival of group A streptococci","volume":"44","author":"Bricker","year":"2002","journal-title":"Mol. Microbiol."},{"key":"2024061316360510000_JCS196014C5","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1016\/S0021-9258(18)93301-6","article-title":"Digestive activity of lysosomes. I. The digestion of proteins by extracts of rat liver lysosomes","volume":"243","author":"Coffey","year":"1968","journal-title":"J. Biol. Chem."},{"key":"2024061316360510000_JCS196014C6","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1042\/bj2370111","article-title":"The effect of the inhibitor diphenylene iodonium on the superoxide-generating system of neutrophils. Specific labelling of a component polypeptide of the oxidase","volume":"237","author":"Cross","year":"1986","journal-title":"Biochem. J."},{"key":"2024061316360510000_JCS196014C7","doi-asserted-by":"publisher","DOI":"10.1002\/0471142735.im1913s91","article-title":"Cecal ligation and puncture","author":"Cuenca","year":"2010","journal-title":"Curr. Protoc. Immunol."},{"key":"2024061316360510000_JCS196014C8","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/ni.2171","article-title":"The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation","volume":"13","author":"Di","year":"2011","journal-title":"Nat. Immunol."},{"key":"2024061316360510000_JCS196014C9","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1002\/cyto.10123","article-title":"Measurement of phagosomal pH of normal and CGD-like human neutrophils by dual fluorescence flow cytometry","volume":"48","author":"Dri","year":"2002","journal-title":"Cytometry"},{"key":"2024061316360510000_JCS196014C10","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/nrmicro2128","article-title":"Antimicrobial mechanisms of phagocytes and bacterial evasion strategies","volume":"7","author":"Flannagan","year":"2009","journal-title":"Nat. Rev. Microbiol."},{"key":"2024061316360510000_JCS196014C11","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1038\/sj.bjp.0705914","article-title":"TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymerase","volume":"143","author":"Fonfria","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"2024061316360510000_JCS196014C12","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1189\/jlb.69.2.191","article-title":"Chronic granulomatous disease: more than the lack of superoxide?","volume":"69","author":"Geiszt","year":"2001","journal-title":"J. Leukoc. Biol."},{"key":"2024061316360510000_JCS196014C13","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1128\/IAI.68.1.125-132.2000","article-title":"Host and bacterial factors involved in the innate ability of mouse macrophages to eliminate internalized unopsonized Escherichia coli","volume":"68","author":"Hamrick","year":"2000","journal-title":"Infect. Immun."},{"key":"2024061316360510000_JCS196014C14","doi-asserted-by":"publisher","first-page":"2709","DOI":"10.1021\/cr900249z","article-title":"Fluorescent indicators for intracellular pH","volume":"110","author":"Han","year":"2010","journal-title":"Chem. Rev."},{"key":"2024061316360510000_JCS196014C15","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S1097-2765(01)00438-5","article-title":"LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death","volume":"9","author":"Hara","year":"2002","journal-title":"Mol. Cell"},{"key":"2024061316360510000_JCS196014C16","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1074\/jbc.M407030200","article-title":"ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation","volume":"280","author":"Hara-Chikuma","year":"2005","journal-title":"J. Biol. Chem."},{"key":"2024061316360510000_JCS196014C17","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1160\/th08-10-0641","article-title":"Role of H(2)O(2)-activated TRPM2 calcium channel in oxidant-induced endothelial injury","volume":"101","author":"Hecquet","year":"2009","journal-title":"Thromb. Haemost."},{"key":"2024061316360510000_JCS196014C18","doi-asserted-by":"publisher","first-page":"1932","DOI":"10.1093\/infdis\/jit103","article-title":"Chloroquine modulates the fungal immune response in phagocytic cells from patients with chronic granulomatous disease","volume":"207","author":"Henriet","year":"2013","journal-title":"J. Infect. Dis."},{"key":"2024061316360510000_JCS196014C19","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/j.str.2009.05.012","article-title":"Structure and function of an ADP-ribose-dependent transcriptional regulator of NAD metabolism","volume":"17","author":"Huang","year":"2009","journal-title":"Structure"},{"key":"2024061316360510000_JCS196014C21","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1038\/nrm2515","article-title":"Phagosome maturation: going through the acid test","volume":"9","author":"Kinchen","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2024061316360510000_JCS196014C22","doi-asserted-by":"publisher","first-page":"11578","DOI":"10.1073\/pnas.1010678108","article-title":"Transient receptor potential melastatin 2 (TRPM2) ion channel is required for innate immunity against Listeria monocytogenes","volume":"108","author":"Knowles","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024061316360510000_JCS196014C23","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s12026-012-8373-8","article-title":"The TRPM2 ion channel, an oxidative stress and metabolic sensor regulating innate immunity and inflammation","volume":"55","author":"Knowles","year":"2013","journal-title":"Immunol. Res."},{"key":"2024061316360510000_JCS196014C24","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1111\/j.1432-1033.1997.00556.x","article-title":"The role of ferredoxin-NADP+ reductase in the concerted cell defense against oxidative damage -- studies using Escherichia coli mutants and cloned plant genes","volume":"249","author":"Krapp","year":"1997","journal-title":"Eur. J. Biochem."},{"key":"2024061316360510000_JCS196014C25","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1111\/imr.12439","article-title":"The life cycle of phagosomes: formation, maturation, and resolution","volume":"273","author":"Levin","year":"2016","journal-title":"Immunol. Rev."},{"key":"2024061316360510000_JCS196014C26","doi-asserted-by":"crossref","first-page":"21099","DOI":"10.1016\/S0021-9258(17)45332-4","article-title":"Phagosomal acidification is mediated by a vacuolar-type H(+)-ATPase in murine macrophages","volume":"265","author":"Lukacs","year":"1990","journal-title":"J. Biol. Chem."},{"key":"2024061316360510000_JCS196014C27","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1054\/ceca.2000.0130","article-title":"Dynamic ca(2+)changes in neutrophil phagosomes A source for intracellular ca(2+)during phagolysosome formation?","volume":"27","author":"Lundqvist-Gustafsson","year":"2000","journal-title":"Cell Calcium"},{"key":"2024061316360510000_JCS196014C28","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1093\/clinchem\/43.8.1325","article-title":"Diagnosis of lysosomal storage disorders: evaluation of lysosome-associated membrane protein LAMP-1 as a diagnostic marker","volume":"43","author":"Meikle","year":"1997","journal-title":"Clin. Chem."},{"key":"2024061316360510000_JCS196014C29","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.jim.2008.11.019","article-title":"A novel method to determine the engulfment of apoptotic cells by macrophages using pHrodo succinimidyl ester","volume":"342","author":"Miksa","year":"2009","journal-title":"J. Immunol. Methods"},{"key":"2024061316360510000_JCS196014C30","doi-asserted-by":"crossref","first-page":"8171","DOI":"10.1016\/S0021-9258(18)83165-9","article-title":"Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores","volume":"264","author":"Minta","year":"1989","journal-title":"J. Biol. Chem."},{"key":"2024061316360510000_JCS196014C31","doi-asserted-by":"publisher","first-page":"7827","DOI":"10.4049\/jimmunol.179.11.7827","article-title":"Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by adp-ribose, the major product generated by the CD38 enzyme reaction","volume":"179","author":"Partida-Sanchez","year":"2007","journal-title":"J. Immunol."},{"key":"2024061316360510000_JCS196014C32","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/35079100","article-title":"ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology","volume":"411","author":"Perraud","year":"2001","journal-title":"Nature"},{"key":"2024061316360510000_JCS196014C33","doi-asserted-by":"publisher","first-page":"6138","DOI":"10.1074\/jbc.M411446200","article-title":"Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels","volume":"280","author":"Perraud","year":"2005","journal-title":"J. Biol. Chem."},{"key":"2024061316360510000_JCS196014C34","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1042\/bj3630417","article-title":"Endolysosomal proteolysis and its regulation","volume":"363","author":"Pillay","year":"2002","journal-title":"Biochem. J."},{"key":"2024061316360510000_JCS196014C35","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/ng0295-202","article-title":"Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production","volume":"9","author":"Pollock","year":"1995","journal-title":"Nat. Genet."},{"key":"2024061316360510000_JCS196014C36","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1097\/ALN.0000000000000275","article-title":"Transient receptor potential melastatin 2 protects mice against polymicrobial sepsis by enhancing bacterial clearance","volume":"121","author":"Qian","year":"2014","journal-title":"Anesthesiology"},{"key":"2024061316360510000_JCS196014C37","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1038\/nri2591","article-title":"The macrophage marches on its phagosome: dynamic assays of phagosome function","volume":"9","author":"Russell","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"2024061316360510000_JCS196014C38","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1164\/rccm.200408-1044SO","article-title":"Pathogen-host interactions in Pseudomonas aeruginosa pneumonia","volume":"171","author":"Sadikot","year":"2005","journal-title":"Am. J. Respir. Crit. Care. Med."},{"key":"2024061316360510000_JCS196014C39","doi-asserted-by":"publisher","first-page":"4923","DOI":"10.4049\/jimmunol.176.8.4923","article-title":"Targeted immunomodulation of the NF-kappaB pathway in airway epithelium impacts host defense against Pseudomonas aeruginosa","volume":"176","author":"Sadikot","year":"2006","journal-title":"J. Immunol."},{"key":"2024061316360510000_JCS196014C40","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.devcel.2013.08.003","article-title":"A TRP channel in the lysosome regulates large particle phagocytosis via focal exocytosis","volume":"26","author":"Samie","year":"2013","journal-title":"Dev. Cell"},{"key":"2024061316360510000_JCS196014C41","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.cell.2006.05.035","article-title":"NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells","volume":"126","author":"Savina","year":"2006","journal-title":"Cell"},{"key":"2024061316360510000_JCS196014C42","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/1357-4310(96)88723-5","article-title":"The NADPH oxidase and chronic granulomatous disease","volume":"2","author":"Segal","year":"1996","journal-title":"Mol. Med. Today"},{"key":"2024061316360510000_JCS196014C43","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1038\/290406a0","article-title":"The respiratory burst of phagocytic cells is associated with a rise in vacuolar pH","volume":"290","author":"Segal","year":"1981","journal-title":"Nature"},{"key":"2024061316360510000_JCS196014C44","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1097\/00005792-200005000-00004","article-title":"Genetic, biochemical, and clinical features of chronic granulomatous disease","volume":"79","author":"Segal","year":"2000","journal-title":"Medicine"},{"key":"2024061316360510000_JCS196014C45","doi-asserted-by":"publisher","DOI":"10.1002\/0471142735.im1430s99","article-title":"Measurement of phagocytosis, phagosome acidification, and intracellular killing of Staphylococcus aureus","author":"Sokolovska","year":"2012","journal-title":"Curr. Protoc. Immunol."},{"key":"2024061316360510000_JCS196014C46","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1042\/BST0351083","article-title":"Phagosomal acidification: measurement, manipulation and functional consequences","volume":"35","author":"Steinberg","year":"2007","journal-title":"Biochem. Soc. Trans."},{"key":"2024061316360510000_JCS196014C47","doi-asserted-by":"publisher","first-page":"9523","DOI":"10.1073\/pnas.0700783104","article-title":"In situ measurement of the electrical potential across the phagosomal membrane using FRET and its contribution to the proton-motive force","volume":"104","author":"Steinberg","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024061316360510000_JCS196014C48","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1083\/jcb.200911083","article-title":"A cation counterflux supports lysosomal acidification","volume":"189","author":"Steinberg","year":"2010","journal-title":"J. Cell Biol."},{"key":"2024061316360510000_JCS196014C49","doi-asserted-by":"publisher","first-page":"407","DOI":"10.3389\/fimmu.2015.00407","article-title":"TRPM2 channel-mediated ROS-sensitive Ca(2+) signaling mechanisms in immune cells","volume":"6","author":"Syed Mortadza","year":"2015","journal-title":"Front. Immunol."},{"key":"2024061316360510000_JCS196014C50","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/ni0311-201","article-title":"A phagocyte dilemma","volume":"12","author":"Thrasher","year":"2011","journal-title":"Nat. Immunol."},{"key":"2024061316360510000_JCS196014C51","doi-asserted-by":"publisher","first-page":"30091","DOI":"10.1074\/jbc.M109.066464","article-title":"Identification of direct and indirect effectors of the transient receptor potential melastatin 2 (TRPM2) cation channel","volume":"285","author":"Toth","year":"2010","journal-title":"J. Biol. Chem."},{"key":"2024061316360510000_JCS196014C52","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1042\/bj20020691","article-title":"Phagosome maturation: aging gracefully","volume":"366","author":"Vieira","year":"2002","journal-title":"Biochem. J."},{"key":"2024061316360510000_JCS196014C53","doi-asserted-by":"publisher","first-page":"23150","DOI":"10.1074\/jbc.M112096200","article-title":"Activation of the cation channel long transient receptor potential channel 2 (LTRPC2) by hydrogen peroxide. A splice variant reveals a mode of activation independent of ADP-ribose","volume":"277","author":"Wehage","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2024061316360510000_JCS196014C54","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1038\/nm1758","article-title":"TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration","volume":"14","author":"Yamamoto","year":"2008","journal-title":"Nat. Med."},{"key":"2024061316360510000_JCS196014C55","doi-asserted-by":"publisher","DOI":"10.1002\/0471142735.im1401s83","article-title":"The isolation and characterization of murine macrophages","author":"Zhang","year":"2008","journal-title":"Curr. Protoc. Immunol."},{"key":"2024061316360510000_JCS196014C56","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001430","article-title":"Transient receptor potential melastatin 2 regulates phagosome maturation and is required for bacterial clearance in Escherichia coli sepsis","author":"Zhang","year":"2017","journal-title":"Anesthesiology"},{"key":"2024061316360510000_JCS196014C57","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1042\/bj3260401","article-title":"Identification of bovine liver mitochondrial NAD+ glycohydrolase as ADP-ribosyl cyclase","volume":"326","author":"Ziegler","year":"1997","journal-title":"Biochem. J."}],"container-title":["Journal of Cell Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1242\/jcs.196014","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/jcs\/article-pdf\/130\/4\/735\/3497521\/jcs196014.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/jcs\/article-pdf\/doi\/10.1242\/jcs.196014\/2057298\/jcs196014.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/jcs\/article-pdf\/130\/4\/735\/3497521\/jcs196014.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T16:54:57Z","timestamp":1718297697000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/jcs\/article\/130\/4\/735\/56628\/Role-of-the-phagosomal-redox-sensitive-TRP-channel"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,15]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,2,15]]}},"URL":"https:\/\/doi.org\/10.1242\/jcs.196014","relation":{},"ISSN":["1477-9137","0021-9533"],"issn-type":[{"value":"1477-9137","type":"electronic"},{"value":"0021-9533","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2,15]]}}}