{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:48:10Z","timestamp":1787021290605,"version":"build-2736575974"},"reference-count":56,"publisher":"The Company of Biologists","issue":"2","license":[{"start":{"date-parts":[[2017,7,15]],"date-time":"2017-07-15T00:00:00Z","timestamp":1500076800000},"content-version":"vor","delay-in-days":181,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM101377"],"award-info":[{"award-number":["GM101377"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The locomotor deficits in the group of diseases referred to as hereditary spastic paraplegia (HSP) reflect degeneration of upper motor neurons, but the mechanisms underlying this neurodegeneration are unknown. We established a Drosophila model for HSP, atlastin (atl), which encodes an ER fusion protein. Here, we show that neuronal atl loss causes degeneration of specific thoracic muscles that is preceded by other pathologies, including accumulation of aggregates containing polyubiquitin, increased generation of reactive oxygen species and activation of the JNK\u2013Foxo stress response pathway. We show that inhibiting the Tor kinase, either genetically or by administering rapamycin, at least partially reversed many of these pathologies. atl loss from muscle also triggered muscle degeneration and rapamycin-sensitive locomotor deficits, as well as polyubiquitin aggregate accumulation. These results indicate that atl loss triggers muscle degeneration both cell autonomously and nonautonomously.<\/jats:p>","DOI":"10.1242\/jcs.196741","type":"journal-article","created":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T21:50:38Z","timestamp":1480629038000},"page":"453-465","source":"Crossref","is-referenced-by-count":24,"title":["Beneficial effects of rapamycin in a\n                    <i>Drosophila<\/i>\n                    model for hereditary spastic paraplegia"],"prefix":"10.1242","volume":"130","author":[{"given":"Shiyu","family":"Xu","sequence":"first","affiliation":[{"name":"Rice University Department of BioSciences, Program in Biochemistry and Cell Biology , , Houston, TX 77005 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Stern","sequence":"additional","affiliation":[{"name":"Rice University Department of BioSciences, Program in Biochemistry and Cell Biology , , Houston, TX 77005 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8459-3664","authenticated-orcid":false,"given":"James A.","family":"McNew","sequence":"additional","affiliation":[{"name":"Rice University Department of BioSciences, Program in Biochemistry and Cell Biology , , Houston, TX 77005 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2024061316345563100_JCS196741C1","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/S0166-2236(98)01276-4","article-title":"Ubiquitin, cellular inclusions and their role in neurodegeneration","volume":"21","author":"Alves-Rodrigues","year":"1998","journal-title":"Trends Neurosci."},{"key":"2024061316345563100_JCS196741C2","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1093\/embo-reports\/kvf094","article-title":"ROS, stress-activated kinases and stress signaling in cancer","volume":"3","author":"Benhar","year":"2002","journal-title":"EMBO Rep."},{"key":"2024061316345563100_JCS196741C3","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1083\/jcb.201306041","article-title":"Where is mTOR and what is it doing there?","volume":"203","author":"Betz","year":"2013","journal-title":"J. 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