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We here showed, by taking advantage of a visible immunoprecipitation assay, that ARL13B interacts with the IFT46\u2013IFT56 (IFT56 is also known as TTC26) dimer of the intraflagellar transport (IFT)-B complex, which mediates anterograde ciliary protein trafficking. However, the ciliary localization of ARL13B was found to be independent of its interaction with IFT-B, but dependent on the ciliary-targeting sequence RVEP in its C-terminal region. ARL13B-knockout cells had shorter cilia than control cells and exhibited aberrant localization of ciliary proteins, including INPP5E. In particular, in ARL13B-knockout cells, the IFT-A and IFT-B complexes accumulated at ciliary tips, and GPR161 (a negative regulator of Hedgehog signaling) could not exit cilia in response to stimulation with Smoothened agonist. This abnormal phenotype was rescued by the exogenous expression of wild-type ARL13B, as well as by its mutant defective in the interaction with IFT-B, but not by its mutants defective in INPP5E binding or in ciliary localization. Thus, ARL13B regulates IFT-A-mediated retrograde protein trafficking within cilia through its interaction with INPP5E.<\/jats:p>","DOI":"10.1242\/jcs.197004","type":"journal-article","created":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T09:25:22Z","timestamp":1482225922000},"page":"563-576","source":"Crossref","is-referenced-by-count":90,"title":["Regulation of ciliary retrograde protein trafficking by the Joubert syndrome proteins ARL13B and INPP5E"],"prefix":"10.1242","volume":"130","author":[{"given":"Shohei","family":"Nozaki","sequence":"first","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Kyoto University 1 , Sakyo-ku, Kyoto 606-8501 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Katoh","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Kyoto University 1 , Sakyo-ku, Kyoto 606-8501 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Terada","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Kyoto University 1 , Sakyo-ku, Kyoto 606-8501 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saki","family":"Michisaka","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Kyoto University 1 , Sakyo-ku, Kyoto 606-8501 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruki","family":"Funabashi","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Kyoto University 1 , Sakyo-ku, Kyoto 606-8501 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senye","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Kyoto University 1 , Sakyo-ku, Kyoto 606-8501 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Kontani","sequence":"additional","affiliation":[{"name":"Meiji Pharmaceutical University 2 Department of Biochemistry , , Kiyose, Tokyo 204-8588 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7701-7183","authenticated-orcid":false,"given":"Kazuhisa","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Kyoto University 1 , Sakyo-ku, Kyoto 606-8501 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2024061316343449700_JCS197004C1","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1126\/science.1240985","article-title":"Molecular basis of tubulin transport within the cilium by IFT74 and IFT81","volume":"341","author":"Bhogaraju","year":"2013","journal-title":"Science"},{"key":"2024061316343449700_JCS197004C2","doi-asserted-by":"publisher","first-page":"11491","DOI":"10.1038\/ncomms11491","article-title":"An organelle-specific protein landscape identifies novel diseases and molecular mechanisms","volume":"7","author":"Boldt","year":"2016","journal-title":"Nat. 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