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In this study, we identified a novel function for Unr, which acts as a positive regulator of placental development. Unr expression studies in the developing placenta revealed the presence of Unr-rich foci that are apparently located in the nuclei of trophoblast giant cells (TGCs). We determined that what we initially thought to be foci, were actually cross sections of a network of double-wall nuclear membrane invaginations that contain a cytoplasmic core related to the nucleoplasmic reticulum (NR). We named them, accordingly, Unr-NRs. Unr-NRs constitute a novel type of NR because they contain high levels of poly(A) RNA and translation factors, and are sites of active translation. In murine tissues, Unr-NRs are only found in two polyploid cell types, in TGCs and hepatocytes. In vitro, their formation is linked to stress and polyploidy because, in three cancer cell lines, cytotoxic drugs that are known to promote polyploidization induce their formation. Finally, we show that Unr is required in vivo for the formation of Unr-containing NRs because these structures are absent in Unr-null TGCs.<\/jats:p>","DOI":"10.1242\/jcs.198697","type":"journal-article","created":{"date-parts":[[2017,4,7]],"date-time":"2017-04-07T02:22:20Z","timestamp":1491531740000},"page":"1796-1808","source":"Crossref","is-referenced-by-count":24,"title":["Unr defines a novel class of nucleoplasmic reticulum involved in mRNA translation"],"prefix":"10.1242","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0724-9680","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Saltel","sequence":"first","affiliation":[{"name":"INSERM UMR1053 Bordeaux Research In Translational Oncology, BaRITOn 1 , F-33000 Bordeaux , France"},{"name":"University of Bordeaux, F-33000 Bordeaux 2 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alban","family":"Giese","sequence":"additional","affiliation":[{"name":"INSERM UMR1053 Bordeaux Research In Translational Oncology, BaRITOn 1 , F-33000 Bordeaux , France"},{"name":"University of Bordeaux, F-33000 Bordeaux 2 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamia","family":"Azzi","sequence":"additional","affiliation":[{"name":"INSERM UMR1053 Bordeaux Research In Translational Oncology, BaRITOn 1 , F-33000 Bordeaux , France"},{"name":"University of Bordeaux, F-33000 Bordeaux 2 , France"},{"name":"CHU 3 Department of Tumor Biology , , F-33000 Bordeaux , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habiba","family":"Elatmani","sequence":"additional","affiliation":[{"name":"INSERM UMR1053 Bordeaux Research In Translational Oncology, BaRITOn 1 , F-33000 Bordeaux , France"},{"name":"University of Bordeaux, F-33000 Bordeaux 2 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Costet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Bordeaux 4 Laboratoire de Transgen\u00e8se , , F-33000 Bordeaux , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zakaria","family":"Ezzoukhry","sequence":"additional","affiliation":[{"name":"INSERM UMR1053 Bordeaux Research In Translational Oncology, BaRITOn 1 , F-33000 Bordeaux , France"},{"name":"University of Bordeaux, F-33000 Bordeaux 2 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Dugot-Senant","sequence":"additional","affiliation":[{"name":"University of Bordeaux, F-33000 Bordeaux 2 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucile","family":"Miquerol","sequence":"additional","affiliation":[{"name":"Aix-Marseille University, CNRS, IBDM UMR 7288 5 , Marseille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Or\u00e9da","family":"Boussadia","sequence":"additional","affiliation":[{"name":"Taconic Europe, Centre d'Affaires DMCI 6 , Lyon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Wodrich","sequence":"additional","affiliation":[{"name":"University of Bordeaux, F-33000 Bordeaux 2 , France"},{"name":"MFP CNRS UMR 5234, Microbiologie Fondamentale et Pathog\u00e9nicit\u00e9, Universit\u00e9 de Bordeaux, F-33000 7 \u2008 Bordeaux , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Dubus","sequence":"additional","affiliation":[{"name":"INSERM UMR1053 Bordeaux Research In Translational Oncology, BaRITOn 1 , F-33000 Bordeaux , France"},{"name":"University of Bordeaux, F-33000 Bordeaux 2 , France"},{"name":"CHU 3 Department of Tumor Biology , , F-33000 Bordeaux , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Jacquemin-Sablon","sequence":"additional","affiliation":[{"name":"INSERM UMR1053 Bordeaux Research In Translational Oncology, BaRITOn 1 , F-33000 Bordeaux , France"},{"name":"University of Bordeaux, F-33000 Bordeaux 2 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2024061316563448700_JCS198697C1","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1101\/gad.371906","article-title":"Drosophila UNR is required for translational repression of male-specific lethal 2 mRNA during regulation of X-chromosome dosage compensation","volume":"20","author":"Abaza","year":"2006","journal-title":"Genes Dev."},{"key":"2024061316563448700_JCS198697C2","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/nrm2694","article-title":"RNA granules: post-transcriptional and epigenetic modulators of gene expression","volume":"10","author":"Anderson","year":"2009","journal-title":"Nat. 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