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Arp2\/3-generated actin regulates diverse cellular processes, including the formation of lamellipodia and filopodia, endocytosis and\/or phagocytosis at the plasma membrane, and the generation of cargo-laden vesicles from organelles including the Golgi, endoplasmic reticulum (ER) and the endo-lysosomal network. Recent studies have also identified roles for WASP family members in promoting actin dynamics at the centrosome, influencing nuclear shape and membrane remodeling events leading to the generation of autophagosomes. Interestingly, several WASP family members have also been observed in the nucleus where they directly influence gene expression by serving as molecular platforms for the assembly of epigenetic and transcriptional machinery. In this Cell Science at a Glance article and accompanying poster, we provide an update on the subcellular roles of WHAMM, JMY and WASH (also known as WASHC1), as well as their mechanisms of regulation and emerging functions within the cell.<\/jats:p>","DOI":"10.1242\/jcs.199570","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T20:30:26Z","timestamp":1498249826000},"page":"2235-2241","source":"Crossref","is-referenced-by-count":205,"title":["Cellular functions of WASP family proteins at a glance"],"prefix":"10.1242","volume":"130","author":[{"given":"Olga","family":"Alekhina","sequence":"first","affiliation":[{"name":"College of Medicine, Mayo Clinic 1 Division of Oncology Research , , Rochester, MN 55905 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezra","family":"Burstein","sequence":"additional","affiliation":[{"name":"UT Southwestern Medical Center 2 Department of Internal Medicine , , Dallas, TX 75390-9151 , USA"},{"name":"UT Southwestern Medical Center 3 Department of Molecular Biology , , Dallas, TX 75390-9151 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2296-9547","authenticated-orcid":false,"given":"Daniel D.","family":"Billadeau","sequence":"additional","affiliation":[{"name":"College of Medicine, Mayo Clinic 1 Division of Oncology Research , , Rochester, MN 55905 , USA"},{"name":"College of Medicine, Mayo Clinic 4 Department of Biochemistry and Molecular Biology , , Rochester, MN 55905 , USA"},{"name":"College of Medicine, Mayo Clinic 5 Department of Immunology , , Rochester, MN 55905 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2024061317013236900_JCS199570C1","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.4161\/auto.21459","article-title":"The actin cytoskeleton participates in the early events of autophagosome formation upon starvation induced autophagy","volume":"8","author":"Aguilera","year":"2014","journal-title":"Autophagy"},{"key":"2024061317013236900_JCS199570C2","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1083\/jcb.201609033","article-title":"Defects in ER\u2013endosome contacts impact lysosome function in hereditary spastic paraplegia","volume":"216","author":"Allison","year":"2017","journal-title":"J. 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