{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T15:52:59Z","timestamp":1772898779172,"version":"3.50.1"},"reference-count":21,"publisher":"The Company of Biologists","issue":"1","license":[{"start":{"date-parts":[[1976,1,1]],"date-time":"1976-01-01T00:00:00Z","timestamp":189302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1976,1,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Vinblastine sulphate (VLB) is known to induce in vivo formation of tubulin paracrystals in sea-urchin eggs. Corresponding paracrystals have been prepared in the presence of both vinblastine sulphate and other mitoclasic agents. Careful standardization of conditions was required to restrict the formation of alternative forms of the paracrystals induced by vinblastine alone. Comparisons were made between preparations in terms of paracrystal shape, size, proportion of eggs containing paracrystals, number per egg and their relative times of first appearance. A correlation between such properties was established. Comparison of paracrystals at the ultrastructural level showed them all to be similar regardless of the drugs present during their formation. The implications of tubulin polymerization in the presence of mitoclasic agents are discussed and mechanisms for paracrystal enhancement by combinations of such drugs are suggested. Some similarities of paracrystal and microtubule seeding are discussed together with the activation of tubulin in the pool.<\/jats:p>","DOI":"10.1242\/jcs.20.1.91","type":"journal-article","created":{"date-parts":[[2021,4,24]],"date-time":"2021-04-24T05:17:09Z","timestamp":1619241429000},"page":"91-100","source":"Crossref","is-referenced-by-count":13,"title":["The effects of mitotic inhibitors on the structure of vinblastine-induced tubulin paracrystals from sea-urchin eggs"],"prefix":"10.1242","volume":"20","author":[{"given":"D.","family":"Starling","sequence":"first","affiliation":[{"name":"University of Edinburgh Department of Zoology , , West Mains Road, Edinburgh EH9 3JT, Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[1976,1,1]]},"reference":[{"key":"2023053020270606700_JOCES_20_1_91C1","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1083\/jcb.40.1.95","article-title":"Microtubule crystals in mammalian cells","volume":"40","author":"Bensch","year":"1969","journal-title":"J. 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Cell division..?","volume":"63","author":"Coss","year":"1974","journal-title":"Cell Biol"},{"key":"2023053020270606700_JOCES_20_1_91C10","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1128\/jb.118.1.59-69.1974","article-title":"Microtubule assembly and function in Chlamydomonas: inhibition of growth and flagellar regeneration by antitubulins and other drugs and isolation of resistance mutants.?","volume":"118","author":"Flavin","year":"1974","journal-title":"Bact"},{"key":"2023053020270606700_JOCES_20_1_91C11","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1038\/244294a0","article-title":"Antimitotic action of griseofulvin does not involve disruption of microtubules","volume":"244","author":"Grisham","year":"1973","journal-title":"Nature, Land"},{"key":"2023053020270606700_JOCES_20_1_91C12","first-page":"967","article-title":"The biological effects and the chemical composition of podophyllin","volume":"14","author":"Kelly","year":"1953","journal-title":"J. natn. 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