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Here, we describe the existence of an integrin \u03b18 (Itga8) and protocadherin-15a (Pcdh15a) ciliary complex in neuromast hair cells in a zebrafish model. Depletion of the complex via downregulation or loss-of-function mutation leads to a dysregulation of cilia biogenesis and endocytosis. At the molecular level, removal of the complex blocks the access of Rab8a into the cilia as well as normal recruitment of ciliary cargo by centriolar satellites. These defects can be reversed by the introduction of a constitutively active form of Rhoa, suggesting that Itga8\u2013Pcdh15a complex mediates its effect through the activation of this small GTPase and probably by the regulation of actin cytoskeleton dynamics. Our data points to a novel mechanism involved in the regulation of sensory cilia development, with the corresponding implications for normal sensory function.<\/jats:p>","DOI":"10.1242\/jcs.206201","type":"journal-article","created":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T00:25:20Z","timestamp":1504830320000},"page":"3698-3712","source":"Crossref","is-referenced-by-count":23,"title":["Integrin \u03b18 and Pcdh15 act as a complex to regulate cilia biogenesis in sensory cells"],"prefix":"10.1242","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9564-6426","authenticated-orcid":false,"given":"Linda","family":"Goodman","sequence":"first","affiliation":[{"name":"Center for Sensory Neuroscience, Boys Town National Research Hospital , Omaha, NE 68131 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6520-988X","authenticated-orcid":false,"given":"Marisa","family":"Zallocchi","sequence":"additional","affiliation":[{"name":"Center for Sensory Neuroscience, Boys Town National Research Hospital , Omaha, NE 68131 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","reference":[{"key":"2024061317130560700_JCS206201C1","doi-asserted-by":"publisher","first-page":"7022","DOI":"10.1523\/JNEUROSCI.1163-06.2006","article-title":"The tip-link antigen, a protein associated with the transduction complex of sensory hair cells, is protocadherin-15","volume":"26","author":"Ahmed","year":"2006","journal-title":"J. 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