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Mutations of MYO7A\/Myo7a have been implicated in inherited deafness in both humans and mice. However, there is limited information about the functions of Myo7a outside of the specialized cells of the ears. Herein, we report a previously unidentified function of Myo7a by demonstrating that it plays an important role in melanoma progression. We found that silencing Myo7a by means of RNAi inhibited melanoma cell growth through upregulation of cell cycle regulator p21 (also known as CDKN1A) and suppressed melanoma cell migration and invasion through downregulation of RhoGDI2 (also known as ARHGDIB) and MMP9. Furthermore, Myo7a depletion suppressed melanoma cell metastases to the lung, kidney and bone in mice. In contrast, overexpression of Myo7a promoted melanoma xenograft growth and lung metastasis. Importantly, Myo7a levels are remarkably elevated in human melanoma patients. Collectively, we demonstrated for the first time that Myo7a is able to function in non-specialized cells, a finding that reveals the complicated disease-related roles of Myo7a, especially in melanomas.<\/jats:p>","DOI":"10.1242\/jcs.209924","type":"journal-article","created":{"date-parts":[[2018,1,20]],"date-time":"2018-01-20T01:35:15Z","timestamp":1516412115000},"source":"Crossref","is-referenced-by-count":15,"title":["Unconventional myosin VIIA promotes melanoma progression"],"prefix":"10.1242","volume":"131","author":[{"given":"Yuqing","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, and State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center 1 Laboratory of Molecular Cell Biology and Tumor Biology, Department of Anatomy, Histology and Embryology , , Beijing 100191 , China"},{"name":"Beijing Neurosurgical Institute and Chinese Glioma Cooperative Group 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