{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:37:11Z","timestamp":1792175831534,"version":"4.4.0"},"reference-count":76,"publisher":"The Company of Biologists","issue":"12","license":[{"start":{"date-parts":[[2018,12,15]],"date-time":"2018-12-15T00:00:00Z","timestamp":1544832000000},"content-version":"vor","delay-in-days":183,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK098398"],"award-info":[{"award-number":["R01 DK098398"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Actomyosin II contractility in epithelial cell plays an essential role in tension-dependent adhesion strengthening. One key unsettling question is how cellular contraction transmits force to the nascent cell\u2013cell adhesion when there is no stable attachment between the nascent adhesion complex and actin filament. Here, we show that myosin-1c is localized to the lateral membrane of polarized epithelial cells and facilitates the coupling between actin and cell\u2013cell adhesion. Knockdown of myosin-1c compromised the integrity of the lateral membrane, reduced the generation of tension at E-cadherin, decreased the strength of cell\u2013cell cohesion in an epithelial cell monolayer and prevented force-dependent recruitment of junctional \u03b1-actinin. Application of exogenous force to cell\u2013cell adhesions in a myosin-1c-knockdown cell monolayer fully rescued the localization defect of \u03b1-actinin, indicating that junction mechanoregulation remains intact in myosin-1c-depleted cells. Our study identifies a role of myosin-1c in force transmission at the lateral cell\u2013cell interface and underscores a non-junctional contribution to tension-dependent junction regulation.<\/jats:p>","DOI":"10.1242\/jcs.211334","type":"journal-article","created":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T07:40:15Z","timestamp":1525938015000},"source":"Crossref","is-referenced-by-count":30,"title":["Myosin-1c promotes E-cadherin tension and force-dependent recruitment of \u03b1-actinin to the epithelial cell junction"],"prefix":"10.1242","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3776-5253","authenticated-orcid":false,"given":"Nivetha","family":"Kannan","sequence":"first","affiliation":[{"name":"University of Illinois Department of Cell and Developmental Biology , , Urbana-Champaign, IL 61801 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8821-6548","authenticated-orcid":false,"given":"Vivian W.","family":"Tang","sequence":"additional","affiliation":[{"name":"University of Illinois Department of Cell and Developmental Biology , , Urbana-Champaign, IL 61801 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2018,6,27]]},"reference":[{"key":"2024080908325712800_JCS211334C1","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1083\/jcb.135.6.1899","article-title":"Quantitative analysis of cadherin-catenin-actin reorganization during development of cell-cell adhesion","volume":"135","author":"Adams","year":"1996","journal-title":"J. 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