{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T22:48:36Z","timestamp":1784069316915,"version":"3.55.0"},"reference-count":67,"publisher":"The Company of Biologists","issue":"8","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"vor","delay-in-days":202,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA015704"],"award-info":[{"award-number":["P30 CA015704"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,4,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>WASH, a Wiskott\u2013Aldrich syndrome (WAS) family protein, has many cell and developmental roles related to its function as a branched actin nucleation factor. Similar to mammalian WASHC1, which is embryonic lethal, Drosophila Wash was found to be essential for oogenesis and larval development. Recently, however, Drosophila wash was reported to be homozygous viable. Here, we verify that the original wash null allele harbors an unrelated lethal background mutation; however, this unrelated lethal mutation does not contribute to any Wash oogenesis phenotypes. Significantly, we find that: (1) the homozygous wash null allele retains partial lethality, leading to non-Mendelian inheritance; (2) the allele's functions are subject to its specific genetic background; and (3) the homozygous stock rapidly accumulates modifications that allow it to become robust. Together, these results suggest that Wash plays an important role in oogenesis via the WASH regulatory complex. Finally, we show that another WAS family protein, SCAR\/WAVE, plays a similar role in oogenesis and that it is upregulated as one of the modifications that allows the wash allele to survive in the homozygous state.<\/jats:p>","DOI":"10.1242\/jcs.211573","type":"journal-article","created":{"date-parts":[[2018,3,16]],"date-time":"2018-03-16T12:18:41Z","timestamp":1521202721000},"source":"Crossref","is-referenced-by-count":13,"title":["Wash exhibits context-dependent phenotypes and, along with the WASH regulatory complex, regulates <i>Drosophila<\/i> oogenesis"],"prefix":"10.1242","volume":"131","author":[{"given":"Jeffrey M.","family":"Verboon","sequence":"first","affiliation":[{"name":"Fred Hutchinson Cancer Research Center Basic Sciences Division , , Seattle, WA , USA \u2008 98109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob R.","family":"Decker","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research Center Basic Sciences Division , , Seattle, WA , USA \u2008 98109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7879-3176","authenticated-orcid":false,"given":"Mitsutoshi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research Center Basic Sciences Division , , Seattle, WA , USA \u2008 98109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5806-9930","authenticated-orcid":false,"given":"Susan M.","family":"Parkhurst","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research Center Basic Sciences Division , , Seattle, WA , USA \u2008 98109"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2018,4,13]]},"reference":[{"key":"2024061318113060000_JCS211573C1","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.1242\/jcs.199570","article-title":"Cellular functions of WASP family proteins at a glance","volume":"130","author":"Alekhina","year":"2017","journal-title":"J. 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