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To that end, hearing was examined in two mouse models of oculodentodigital dysplasia that globally express GJA1 mutations resulting in mild or severe loss of Cx43 function. Although Cx43I130T\/+ mutant mice, with \u223c50% Cx43 channel function, did not have any hearing loss, Cx43G60S\/+ mutant mice, with \u223c20% Cx43 channel function, had severe hearing loss. There was no evidence of inner ear sensory hair cell loss, suggesting that the mechanism for Cx43-linked hearing loss lies downstream in the auditory pathway. Since evidence suggests that Cx26 function is essential for hearing and may be protective against noise-induced hearing loss, we challenged Cx43I130T\/+ mice with a loud noise and found that they had a similar susceptibility to noise-induced hearing loss to that found in controls, suggesting that decreased Cx43 function does not sensitize the mice for environmentally induced hearing loss. Taken together, this study suggests that Cx43 plays an important role in baseline hearing and is essential for auditory processing.<\/jats:p>\n               <jats:p>This article has an associated First Person interview with the first author of the paper.<\/jats:p>","DOI":"10.1242\/jcs.214635","type":"journal-article","created":{"date-parts":[[2018,4,4]],"date-time":"2018-04-04T11:40:20Z","timestamp":1522842020000},"source":"Crossref","is-referenced-by-count":16,"title":["Mice harbouring an oculodentodigital dysplasia-linked Cx43 G60S mutation have severe hearing loss"],"prefix":"10.1242","volume":"131","author":[{"given":"Julia M.","family":"Abitbol","sequence":"first","affiliation":[{"name":"University of Western Ontario , Department of Anatomy and Cell Biology, London, Ontario , Canada, N6A 5C1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Kelly","sequence":"additional","affiliation":[{"name":"University of Western Ontario , Department of Anatomy and Cell Biology, London, Ontario , Canada, N6A 5C1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Barr","sequence":"additional","affiliation":[{"name":"University of Western Ontario , Department of Anatomy and Cell Biology, London, Ontario , Canada, N6A 5C1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian L.","family":"Allman","sequence":"additional","affiliation":[{"name":"University of Western Ontario , Department of Anatomy and Cell Biology, London, Ontario , Canada, N6A 5C1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4568-3285","authenticated-orcid":false,"given":"Dale W.","family":"Laird","sequence":"additional","affiliation":[{"name":"University of Western Ontario , Department of Anatomy and Cell Biology, London, Ontario , Canada, N6A 5C1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2018,5,4]]},"reference":[{"key":"2024061318121982400_JCS214635C1","doi-asserted-by":"publisher","first-page":"4665","DOI":"10.1042\/BCJ20160668","article-title":"Differential effects of pannexins on noise-induced hearing loss","volume":"473","author":"Abitbol","year":"2016","journal-title":"Biochem. 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