{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:00:12Z","timestamp":1790532012513,"version":"4.1.0"},"reference-count":102,"publisher":"The Company of Biologists","issue":"22","license":[{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"vor","delay-in-days":181,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01EY028558"],"award-info":[{"award-number":["R01EY028558"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01EY022113"],"award-info":[{"award-number":["R01EY022113"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Research Foundation of Oregon","award":["1611"],"award-info":[{"award-number":["1611"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,11,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Lens epithelial cells are bound to the lens extracellular matrix capsule, of which laminin is a major component. After cataract surgery, surviving lens epithelial cells are exposed to increased levels of fibronectin, and so we addressed whether fibronectin influences lens cell fate, using DCDML cells as a serum-free primary lens epithelial cell culture system. We found that culturing DCDMLs with plasma-derived fibronectin upregulated canonical TGF\u03b2 signaling relative to cells plated on laminin. Fibronectin-exposed cultures also showed increased TGF\u03b2 signaling-dependent differentiation into the two cell types responsible for posterior capsule opacification after cataract surgery, namely myofibroblasts and lens fiber cells. Increased TGF\u03b2 activity could be identified in the conditioned medium recovered from cells grown on fibronectin. Other experiments showed that plating DCDMLs on fibronectin overcomes the need for BMP in fibroblast growth factor (FGF)-induced lens fiber cell differentiation, a requirement that is restored when endogenous TGF\u03b2 signaling is inhibited. These results demonstrate how the TGF\u03b2\u2013fibronectin axis can profoundly affect lens cell fate. This axis represents a novel target for prevention of late-onset posterior capsule opacification, a common but currently intractable complication of cataract surgery.<\/jats:p>","DOI":"10.1242\/jcs.217240","type":"journal-article","created":{"date-parts":[[2018,11,7]],"date-time":"2018-11-07T15:29:21Z","timestamp":1541604561000},"source":"Crossref","is-referenced-by-count":29,"title":["Fibronectin regulates growth factor signaling and cell differentiation in primary lens cells"],"prefix":"10.1242","volume":"131","author":[{"given":"Judy K.","family":"VanSlyke","sequence":"first","affiliation":[{"name":"Oregon Health & Science University Department of Biochemistry and Molecular Biology , , Portland, OR 97239 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce A.","family":"Boswell","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University Department of Biochemistry and Molecular Biology , , Portland, OR 97239 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4630-825X","authenticated-orcid":false,"given":"Linda S.","family":"Musil","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University Department of Biochemistry and Molecular Biology , , Portland, OR 97239 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2018,11,20]]},"reference":[{"key":"2024061318012298700_JCS217240C1","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1083\/jcb.200312172","article-title":"Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1","volume":"165","author":"Annes","year":"2004","journal-title":"J. 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