{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:45:19Z","timestamp":1792035919835,"version":"4.4.0"},"reference-count":164,"publisher":"The Company of Biologists","issue":"10","license":[{"start":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T00:00:00Z","timestamp":1558396800000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/www.biologists.com\/user-licence-1-1"}],"funder":[{"DOI":"10.13039\/501100007155","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC\u00a0UU\u00a012018\/3"],"award-info":[{"award-number":["MC\u00a0UU\u00a012018\/3"]}],"id":[{"id":"10.13039\/501100007155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007155","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC\u00a0UU\u00a000012\/3"],"award-info":[{"award-number":["MC\u00a0UU\u00a000012\/3"]}],"id":[{"id":"10.13039\/501100007155","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Cdc42 \u2013 a member of the small Rho GTPase family \u2013 regulates cell polarity across organisms from yeast to humans. It is an essential regulator of polarized morphogenesis in epithelial cells, through coordination of apical membrane morphogenesis, lumen formation and junction maturation. In parallel, work in yeast and Caenorhabditis\u2008elegans has provided important clues as to how this molecular switch can generate and regulate polarity through localized activation or inhibition, and cytoskeleton regulation. Recent studies have revealed how important and complex these regulations can be during epithelial morphogenesis. This complexity is mirrored by the fact that Cdc42 can exert its function through many effector proteins. In epithelial cells, these include atypical PKC (aPKC, also known as PKC-3), the P21-activated kinase (PAK) family, myotonic dystrophy-related Cdc42 binding kinase beta (MRCK\u03b2, also known as CDC42BPB) and neural Wiskott\u2013Aldrich syndrome protein (N-WASp, also known as WASL). Here, we review how the spatial regulation of Cdc42 promotes polarity and polarized morphogenesis of the plasma membrane, with a focus on the epithelial cell type.<\/jats:p>","DOI":"10.1242\/jcs.217869","type":"journal-article","created":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T14:48:22Z","timestamp":1558450102000},"source":"Crossref","is-referenced-by-count":120,"title":["Regulation of Cdc42 and its effectors in epithelial morphogenesis"],"prefix":"10.1242","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8393-716X","authenticated-orcid":false,"given":"Franck","family":"Pichaud","sequence":"first","affiliation":[{"name":"University College London 1 MRC - Laboratory for Molecular Cell Biology , , London WC1E 6BT , UK"},{"name":"University College London 2 Institute for the Physics of Living Systems , , London WC1E 6BT , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhian F.","family":"Walther","sequence":"additional","affiliation":[{"name":"University College London 1 MRC - Laboratory for Molecular Cell Biology , , London WC1E 6BT , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Nunes de Almeida","sequence":"additional","affiliation":[{"name":"University College London 1 MRC - Laboratory for Molecular Cell Biology , , London WC1E 6BT , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2019,5,21]]},"reference":[{"key":"2024061318135387300_JCS217869C1","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.ydbio.2006.08.002","article-title":"Interaction of PAR-6 with CDC-42 is required for maintenance but not establishment of PAR asymmetry in C. elegans","volume":"299","author":"Aceto","year":"2006","journal-title":"Dev. 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