{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:41:23Z","timestamp":1765827683423,"version":"3.41.2"},"reference-count":63,"publisher":"The Company of Biologists","issue":"16","license":[{"start":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T00:00:00Z","timestamp":1518652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GI 770 1-1\/1-2"],"award-info":[{"award-number":["GI 770 1-1\/1-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Charlotte & Tistou Kerstan Foundation."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Pericentrin (Pcnt) is a multifunctional scaffold protein and mutations in the human PCNT gene are associated with several diseases, including ciliopathies. Pcnt plays a crucial role in ciliary development in olfactory receptor neurons, but its function in the photoreceptor-connecting cilium is unknown. We downregulated Pcnt in the retina ex vivo and in vivo via a virus-based RNA interference approach to study Pcnt function in photoreceptors. ShRNA-mediated knockdown of Pcnt impaired the development of the connecting cilium and the outer segment of photoreceptors, and caused a nuclear migration defect. In protein interaction screens, we found that the outer nuclear membrane protein Syne-2 (also known as Nesprin-2) is an interaction partner of Pcnt in photoreceptors. Syne-2 is important for positioning murine photoreceptor cell nuclei and for centrosomal migration during early ciliogenesis. CRISPR\/Cas9-mediated knockout of Syne-2 in cell culture led to an overexpression and mislocalization of Pcnt and to ciliogenesis defects. Our findings suggest that the Pcnt\u2013Syne-2 complex is important for ciliogenesis and outer segment formation during retinal development and plays a role in nuclear migration.<\/jats:p>","DOI":"10.1242\/jcs.218487","type":"journal-article","created":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T13:39:32Z","timestamp":1532698772000},"source":"Crossref","is-referenced-by-count":10,"title":["Functional analyses of Pericentrin and Syne-2 interaction in ciliogenesis"],"prefix":"10.1242","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6722-0292","authenticated-orcid":false,"given":"Nathalie","family":"Falk","sequence":"first","affiliation":[{"name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg 1 Animal Physiology , , 91058 Erlangen , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin","family":"Kessler","sequence":"additional","affiliation":[{"name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg 1 Animal 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Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen 3 Center for Integrated Protein Science Munich (CIPSM) at the Department of Pharmacy , , 81377 Munich , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5092-9238","authenticated-orcid":false,"given":"Stylianos","family":"Michalakis","sequence":"additional","affiliation":[{"name":"Center for Drug Research, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen 3 Center for Integrated Protein Science Munich (CIPSM) at the Department of Pharmacy , , 81377 Munich , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5004-8534","authenticated-orcid":false,"given":"Hanna","family":"Regus-Leidig","sequence":"additional","affiliation":[{"name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg 1 Animal Physiology , , 91058 Erlangen , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8260-6732","authenticated-orcid":false,"given":"Angelika A.","family":"Noegel","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry I 4 , Medical Faculty , , 50931 Cologne , Germany"},{"name":"University Hospital, University of Cologne 4 , Medical Faculty , , 50931 Cologne , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2209-2113","authenticated-orcid":false,"given":"Marius","family":"Ueffing","sequence":"additional","affiliation":[{"name":"Center of Ophthalmology, University of T\u00fcbingen 2 Division of Experimental Ophthalmology and Medical Proteome Center , , 72074 T\u00fcbingen , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3817-7277","authenticated-orcid":false,"given":"Christian 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