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In fibroblasts plated onto islands of optimal size, an initially circular actin pattern evolves into a radial pattern of actin bundles that undergo asymmetric chiral swirling before finally producing parallel linear stress fibres. Epitheliocytes however, did not exhibit succession through all the actin patterns described above. Upon confinement, the actin cytoskeleton in non-keratinocyte epitheliocytes was arrested at the circular stage, while in keratinocytes it progressed as far as the radial pattern but still could not break symmetry. Epithelial-mesenchymal transition pushed actin cytoskeleton development from circular towards radial patterns but remained insufficient to cause chirality. Knockout of cytokeratins also did not promote actin chirality development in keratinocytes. Left-right asymmetric cytoskeleton swirling could, however, be induced in keratinocytes by small doses of G-actin sequestering drug, latrunculin A in a transcription independent manner. Both the nucleus and the cytokeratin network followed the induced chiral swirling. Development of chirality in keratinocytes was controlled by DIAPH1 (mDia1) and VASP, proteins involved in regulation of actin polymerization.<\/jats:p>","DOI":"10.1242\/jcs.220780","type":"journal-article","created":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T15:55:20Z","timestamp":1550678120000},"source":"Crossref","is-referenced-by-count":61,"title":["Actin cytoskeleton self-organization in single epithelial cells and fibroblasts under isotropic confinement"],"prefix":"10.1242","author":[{"given":"Salma","family":"Jalal","sequence":"first","affiliation":[{"name":"Mechanobiology Institute, National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shidong","family":"Shi","sequence":"additional","affiliation":[{"name":"Mechanobiology Institute, National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidhyalakshmi","family":"Acharya","sequence":"additional","affiliation":[{"name":"Mechanobiology Institute, National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruby Yun-Ju","family":"Huang","sequence":"additional","affiliation":[{"name":"Cancer Science Institute of Singapore, National University of Singapore, Singapore"},{"name":"Department of Obstetrics & Gynaecology, National University Hospital, Singapore"},{"name":"Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virgile","family":"Viasnoff","sequence":"additional","affiliation":[{"name":"Mechanobiology Institute, National University of Singapore, Singapore"},{"name":"Centre National Pour la Recherche Scientifique, Singapore"},{"name":"Department of Biological Sciences, National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Bershadsky","sequence":"additional","affiliation":[{"name":"Mechanobiology Institute, National University of Singapore, Singapore"},{"name":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9779-0915","authenticated-orcid":false,"given":"Yee Han","family":"Tee","sequence":"additional","affiliation":[{"name":"Mechanobiology Institute, National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2019,1,1]]},"reference":[{"key":"2021042422361203600_JCS220780C1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/S0076-6879(98)98004-1","article-title":"Use of latrunculin-A, an actin monomer-binding drug","volume":"298","author":"Ayscough","year":"1998","journal-title":"Methods Enzymol."},{"key":"2021042422361203600_JCS220780C2","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1083\/jcb.137.2.399","article-title":"High rates of actin filament turnover in budding yeast and roles for actin in establishment and maintenance of cell polarity revealed using the actin inhibitor latrunculin-A","volume":"137","author":"Ayscough","year":"1997","journal-title":"J. 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