{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T23:25:15Z","timestamp":1783639515711,"version":"3.55.0"},"reference-count":33,"publisher":"The Company of Biologists","issue":"6","license":[{"start":{"date-parts":[[2019,3,16]],"date-time":"2019-03-16T00:00:00Z","timestamp":1552694400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31700926"],"award-info":[{"award-number":["31700926"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31730031"],"award-info":[{"award-number":["31730031"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Collegiate Natural Science Fund of Jiangsu Province","award":["16KJA310005"],"award-info":[{"award-number":["16KJA310005"]}]},{"name":"Natural Science Foundation of Nantong","award":["MS12017015-2"],"award-info":[{"award-number":["MS12017015-2"]}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Tau protein (encoded by the gene microtubule-associated protein tau, Mapt) is essential for the assembly and stability of microtubule and the functional maintenance of the nervous system. Tau is highly abundant in neurons and is detectable in astrocytes and oligodendrocytes. However, whether tau is present in Schwann cells, the unique glial cells in the peripheral nervous system, is unclear. Here, we investigated the presence of tau and its coding mRNA, Mapt, in cultured Schwann cells and find that tau is present in these cells. Gene silencing of Mapt promoted Schwann cell proliferation and inhibited Schwann cell migration and differentiation. In vivo application of Mapt siRNA suppressed the migration of Schwann cells after sciatic nerve injury. Consistent with this, Mapt-knockout mice showed elevated proliferation and reduced migration of Schwann cells. Rats injected with Mapt siRNA and Mapt-knockout mice also exhibited impaired myelin and lipid debris clearance. The expression and distribution of the cytoskeleton proteins \u03b1-tubulin and F-actin were also disrupted in these animals. These findings demonstrate the existence and biological effects of tau in Schwann cells, and expand our understanding of the function of tau in the nervous system.<\/jats:p>","DOI":"10.1242\/jcs.222059","type":"journal-article","created":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T15:05:41Z","timestamp":1550588741000},"source":"Crossref","is-referenced-by-count":48,"title":["Tau modulates Schwann cell proliferation, migration and differentiation following peripheral nerve injury"],"prefix":"10.1242","volume":"132","author":[{"given":"Sheng","family":"Yi","sequence":"first","affiliation":[{"name":"Co-innovation Center of Neuroregeneration, Nantong University Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education , , Nantong, Jiangsu 226001 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Co-innovation Center of Neuroregeneration, Nantong University Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education , , Nantong, Jiangsu 226001 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghui","family":"Wang","sequence":"additional","affiliation":[{"name":"Co-innovation Center of Neuroregeneration, Nantong University Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education , , Nantong, Jiangsu 226001 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianmei","family":"Qian","sequence":"additional","affiliation":[{"name":"Co-innovation Center of Neuroregeneration, Nantong University Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education , , Nantong, Jiangsu 226001 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongkui","family":"Wang","sequence":"additional","affiliation":[{"name":"Co-innovation Center of Neuroregeneration, Nantong University Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education , , Nantong, Jiangsu 226001 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8341-7033","authenticated-orcid":false,"given":"Guangbin","family":"Zha","sequence":"additional","affiliation":[{"name":"Co-innovation Center of Neuroregeneration, Nantong University Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education , , Nantong, Jiangsu 226001 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2557-3633","authenticated-orcid":false,"given":"Jun","family":"Yu","sequence":"additional","affiliation":[{"name":"Co-innovation Center of Neuroregeneration, Nantong University Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education , , Nantong, Jiangsu 226001 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3376-5213","authenticated-orcid":false,"given":"Pan","family":"Wang","sequence":"additional","affiliation":[{"name":"Co-innovation Center of Neuroregeneration, Nantong University Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education , , Nantong, Jiangsu 226001 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaosong","family":"Gu","sequence":"additional","affiliation":[{"name":"Co-innovation Center of Neuroregeneration, Nantong University Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education , , Nantong, Jiangsu 226001 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Chu","sequence":"additional","affiliation":[{"name":"Co-innovation Center of Neuroregeneration, Nantong University Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education , , Nantong, Jiangsu 226001 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5150-7299","authenticated-orcid":false,"given":"Shiying","family":"Li","sequence":"additional","affiliation":[{"name":"Co-innovation Center of Neuroregeneration, Nantong University Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education , , Nantong, Jiangsu 226001 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2019,3,18]]},"reference":[{"key":"2024061318211839800_JCS222059C1","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1002\/glia.21144","article-title":"Mouse schwann cells need both NRG1 and cyclic AMP to myelinate","volume":"59","author":"Arthur-Farraj","year":"2011","journal-title":"Glia"},{"key":"2024061318211839800_JCS222059C2","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1177\/1073858417742125","article-title":"CNS injury: posttranslational modification of the tau protein 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