{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:47:32Z","timestamp":1792165652003,"version":"4.4.0"},"reference-count":100,"publisher":"The Company of Biologists","issue":"20","license":[{"start":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T00:00:00Z","timestamp":1571616000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/www.biologists.com\/user-licence-1-1"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["086598"],"award-info":[{"award-number":["086598"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["214272"],"award-info":[{"award-number":["214272"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cell Sci"],"published-print":{"date-parts":[[2019,10,15]]},"DOI":"10.1242\/jcs.222992","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T13:23:04Z","timestamp":1571664184000},"page":"jcs222992","source":"Crossref","is-referenced-by-count":154,"title":["Adaptor protein complexes and disease at a glance"],"prefix":"10.1242","volume":"132","author":[{"given":"Anneri","family":"Sanger","sequence":"first","affiliation":[{"name":"Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Hirst","sequence":"additional","affiliation":[{"name":"Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra K.","family":"Davies","sequence":"additional","affiliation":[{"name":"Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0631-0053","authenticated-orcid":false,"given":"Margaret S.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2019,10,21]]},"reference":[{"key":"2019102106050502000_132.20.jcs222992.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.04.019"},{"key":"2019102106050502000_132.20.jcs222992.2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-09-671636"},{"key":"2019102106050502000_132.20.jcs222992.3","doi-asserted-by":"publisher","DOI":"10.1038\/270695a0"},{"key":"2019102106050502000_132.20.jcs222992.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.10.009"},{"key":"2019102106050502000_132.20.jcs222992.5","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.146886"},{"key":"2019102106050502000_132.20.jcs222992.6","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2990"},{"key":"2019102106050502000_132.20.jcs222992.7","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.72.121801.161800"},{"key":"2019102106050502000_132.20.jcs222992.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2010.01.015"},{"key":"2019102106050502000_132.20.jcs222992.9","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1016\/S0021-9258(19)39742-X","article-title":"NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor","volume":"265","author":"Chen","year":"1990","journal-title":"J. Biol. Chem."},{"key":"2019102106050502000_132.20.jcs222992.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00735-3"},{"key":"2019102106050502000_132.20.jcs222992.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2017.04.001"},{"key":"2019102106050502000_132.20.jcs222992.12","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2478"},{"key":"2019102106050502000_132.20.jcs222992.13","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06172-7"},{"key":"2019102106050502000_132.20.jcs222992.14","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90533-7"},{"key":"2019102106050502000_132.20.jcs222992.15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007363"},{"key":"2019102106050502000_132.20.jcs222992.16","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.24.15078"},{"key":"2019102106050502000_132.20.jcs222992.17","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5362.431"},{"key":"2019102106050502000_132.20.jcs222992.18","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80170-7"},{"key":"2019102106050502000_132.20.jcs222992.19","doi-asserted-by":"publisher","DOI":"10.1038\/ng1082"},{"key":"2019102106050502000_132.20.jcs222992.20","doi-asserted-by":"publisher","DOI":"10.1126\/science.aab1121"},{"key":"2019102106050502000_132.20.jcs222992.21","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3117"},{"key":"2019102106050502000_132.20.jcs222992.22","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e07-01-0012"},{"key":"2019102106050502000_132.20.jcs222992.23","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38561"},{"key":"2019102106050502000_132.20.jcs222992.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.08.013"},{"key":"2019102106050502000_132.20.jcs222992.25","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81650-5"},{"key":"2019102106050502000_132.20.jcs222992.26","doi-asserted-by":"publisher","DOI":"10.1038\/nature01020"},{"key":"2019102106050502000_132.20.jcs222992.27","doi-asserted-by":"publisher","DOI":"10.1126\/science.1060458"},{"key":"2019102106050502000_132.20.jcs222992.28","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2010.15"},{"key":"2019102106050502000_132.20.jcs222992.29","doi-asserted-by":"publisher","DOI":"10.1038\/383447a0"},{"key":"2019102106050502000_132.20.jcs222992.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.12.089"},{"key":"2019102106050502000_132.20.jcs222992.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2013.10.006"},{"key":"2019102106050502000_132.20.jcs222992.32","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.05.013"},{"key":"2019102106050502000_132.20.jcs222992.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2019.04.001"},{"key":"2019102106050502000_132.20.jcs222992.34","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0600312103"},{"key":"2019102106050502000_132.20.jcs222992.35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001170"},{"key":"2019102106050502000_132.20.jcs222992.36","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2012.07.012"},{"key":"2019102106050502000_132.20.jcs222992.37","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E13-03-0170"},{"key":"2019102106050502000_132.20.jcs222992.38","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.02866"},{"key":"2019102106050502000_132.20.jcs222992.39","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv220"},{"key":"2019102106050502000_132.20.jcs222992.40","doi-asserted-by":"publisher","DOI":"10.1212\/NXG.0000000000000098"},{"key":"2019102106050502000_132.20.jcs222992.41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2004411"},{"key":"2019102106050502000_132.20.jcs222992.42","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.12.7.2075"},{"key":"2019102106050502000_132.20.jcs222992.43","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.16950"},{"key":"2019102106050502000_132.20.jcs222992.44","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.08.063"},{"key":"2019102106050502000_132.20.jcs222992.45","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1615302"},{"key":"2019102106050502000_132.20.jcs222992.46","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.05.006"},{"key":"2019102106050502000_132.20.jcs222992.47","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E14-07-1177"},{"key":"2019102106050502000_132.20.jcs222992.48","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E05-03-0213"},{"key":"2019102106050502000_132.20.jcs222992.49","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200307157"},{"key":"2019102106050502000_132.20.jcs222992.50","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.105.5.1989"},{"key":"2019102106050502000_132.20.jcs222992.51","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(79)90007-2"},{"key":"2019102106050502000_132.20.jcs222992.52","doi-asserted-by":"publisher","DOI":"10.1038\/nature07422"},{"key":"2019102106050502000_132.20.jcs222992.53","doi-asserted-by":"publisher","DOI":"10.1126\/science.1254836"},{"key":"2019102106050502000_132.20.jcs222992.54","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E08-07-0712"},{"key":"2019102106050502000_132.20.jcs222992.55","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2019.03.026"},{"key":"2019102106050502000_132.20.jcs222992.56","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a016725"},{"key":"2019102106050502000_132.20.jcs222992.57","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2007.04.021"},{"key":"2019102106050502000_132.20.jcs222992.58","doi-asserted-by":"publisher","DOI":"10.1597\/09-145"},{"key":"2019102106050502000_132.20.jcs222992.59","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.02.018"},{"key":"2019102106050502000_132.20.jcs222992.60","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt012"},{"key":"2019102106050502000_132.20.jcs222992.61","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.02.012"},{"key":"2019102106050502000_132.20.jcs222992.62","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1717327114"},{"key":"2019102106050502000_132.20.jcs222992.63","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.01.022"},{"key":"2019102106050502000_132.20.jcs222992.64","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a017038"},{"key":"2019102106050502000_132.20.jcs222992.65","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.10.2193"},{"key":"2019102106050502000_132.20.jcs222992.66","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.08.019"},{"key":"2019102106050502000_132.20.jcs222992.67","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf487"},{"key":"2019102106050502000_132.20.jcs222992.68","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.252630799"},{"key":"2019102106050502000_132.20.jcs222992.69","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.21.9318-9323.2005"},{"key":"2019102106050502000_132.20.jcs222992.70","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000296"},{"key":"2019102106050502000_132.20.jcs222992.71","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200405032"},{"key":"2019102106050502000_132.20.jcs222992.72","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1300253"},{"key":"2019102106050502000_132.20.jcs222992.73","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2492"},{"key":"2019102106050502000_132.20.jcs222992.74","doi-asserted-by":"publisher","DOI":"10.1126\/science.7569928"},{"key":"2019102106050502000_132.20.jcs222992.75","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5392.1327"},{"key":"2019102106050502000_132.20.jcs222992.76","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1984.tb02075.x"},{"key":"2019102106050502000_132.20.jcs222992.77","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200311064"},{"key":"2019102106050502000_132.20.jcs222992.78","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200107140"},{"key":"2019102106050502000_132.20.jcs222992.79","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu121"},{"key":"2019102106050502000_132.20.jcs222992.80","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.12.042"},{"key":"2019102106050502000_132.20.jcs222992.81","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0854.2002.31007.x"},{"key":"2019102106050502000_132.20.jcs222992.82","doi-asserted-by":"publisher","DOI":"10.1111\/tra.12335"},{"key":"2019102106050502000_132.20.jcs222992.83","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(00)00235-0"},{"key":"2019102106050502000_132.20.jcs222992.84","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E04-10-0892"},{"key":"2019102106050502000_132.20.jcs222992.85","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.04.005"},{"key":"2019102106050502000_132.20.jcs222992.86","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.137.4.835"},{"key":"2019102106050502000_132.20.jcs222992.87","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E11-06-0509"},{"key":"2019102106050502000_132.20.jcs222992.88","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000408"},{"key":"2019102106050502000_132.20.jcs222992.89","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2561"},{"key":"2019102106050502000_132.20.jcs222992.90","doi-asserted-by":"publisher","DOI":"10.1038\/nature04339"},{"key":"2019102106050502000_132.20.jcs222992.91","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.04.056"},{"key":"2019102106050502000_132.20.jcs222992.92","doi-asserted-by":"publisher","DOI":"10.1086\/510137"},{"key":"2019102106050502000_132.20.jcs222992.93","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E05-07-0626"},{"key":"2019102106050502000_132.20.jcs222992.94","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2751"},{"key":"2019102106050502000_132.20.jcs222992.95","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a016790"},{"key":"2019102106050502000_132.20.jcs222992.96","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.06.004"},{"key":"2019102106050502000_132.20.jcs222992.97","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2017.1314897"},{"key":"2019102106050502000_132.20.jcs222992.98","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv002"},{"key":"2019102106050502000_132.20.jcs222992.99","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.97.5.1339"},{"key":"2019102106050502000_132.20.jcs222992.100","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.9.5385"}],"container-title":["Journal of Cell Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1242\/jcs.222992","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1242\/jcs.222992","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T16:53:15Z","timestamp":1611593595000},"score":1,"resource":{"primary":{"URL":"http:\/\/jcs.biologists.org\/lookup\/doi\/10.1242\/jcs.222992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,15]]},"references-count":100,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2019,10,21]]},"published-print":{"date-parts":[[2019,10,15]]}},"alternative-id":["10.1242\/jcs.222992"],"URL":"https:\/\/doi.org\/10.1242\/jcs.222992","relation":{},"ISSN":["0021-9533","1477-9137"],"issn-type":[{"value":"0021-9533","type":"print"},{"value":"1477-9137","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,15]]}}}