{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:14:27Z","timestamp":1793830467979,"version":"4.6.1"},"reference-count":41,"publisher":"The Company of Biologists","issue":"6","license":[{"start":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T00:00:00Z","timestamp":1553212800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa de Minas Gerais"},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Intracellular parasites of the genus Leishmania are the causative agents of leishmaniasis. The disease is transmitted by the bite of a sand fly vector, which inoculates the parasite into the skin of mammalian hosts, including humans. During chronic infection the parasite lives and replicates inside phagocytic cells, notably the macrophages. An interesting, but overlooked finding, is that other cell types and even non-phagocytic cells have been found to be infected by Leishmania spp. Nevertheless, the mechanisms by which Leishmania invades such cells had not been previously studied. Here, we show that L. amazonensis can induce their own entry into fibroblasts independently of actin cytoskeleton activity, and, thus, through a mechanism that is distinct from phagocytosis. Invasion involves subversion of host cell functions, such as Ca2+ signaling and recruitment and exocytosis of host cell lysosomes involved in plasma membrane repair.<\/jats:p>\n               <jats:p>This article has an associated First Person interview with the first author of the paper.<\/jats:p>","DOI":"10.1242\/jcs.226183","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T14:34:47Z","timestamp":1551278087000},"source":"Crossref","is-referenced-by-count":38,"title":["<i>Leishmania amazonensis<\/i> hijacks host cell lysosomes involved in plasma membrane repair to induce invasion in fibroblasts"],"prefix":"10.1242","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2537-5514","authenticated-orcid":false,"given":"Victor Soares","family":"Cavalcante-Costa","sequence":"first","affiliation":[{"name":"Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais 1 Departamento de Bioqu\u00edmica e Imunologia , , Minas Gerais, CEP 31270-901 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7878-8833","authenticated-orcid":false,"given":"Mariana","family":"Costa-Reginaldo","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais 1 Departamento de Bioqu\u00edmica e Imunologia , , Minas Gerais, CEP 31270-901 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0306-0159","authenticated-orcid":false,"given":"Thamires","family":"Queiroz-Oliveira","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais 1 Departamento de Bioqu\u00edmica e Imunologia , , Minas Gerais, CEP 31270-901 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anny C. S.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais 2 Departamento de Morfologia , , Minas Gerais, CEP 31270-901 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0491-7062","authenticated-orcid":false,"given":"Nat\u00e1lia Fernanda","family":"Couto","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais 2 Departamento de Morfologia , , Minas Gerais, CEP 31270-901 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle Oliveira","family":"dos Anjos","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Santa Cruz 3 Departamento de Ci\u00eancias Biol\u00f3gicas , , Bahia, CEP 45662-900 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Lima-Santos","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Santa Cruz 3 Departamento de Ci\u00eancias Biol\u00f3gicas , , Bahia, CEP 45662-900 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Oliveira","family":"Andrade","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais 2 Departamento de Morfologia , , Minas Gerais, CEP 31270-901 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria F\u00e1tima","family":"Horta","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais 1 Departamento de Bioqu\u00edmica e Imunologia , , Minas Gerais, CEP 31270-901 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1564-4645","authenticated-orcid":false,"given":"Thiago","family":"Castro-Gomes","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais 1 Departamento de Bioqu\u00edmica e Imunologia , , Minas Gerais, CEP 31270-901 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2019,3,25]]},"reference":[{"key":"2024061318214479900_JCS226183C1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.semcdb.2015.09.022","article-title":"Above the fray: Surface remodeling by secreted lysosomal enzymes leads to endocytosis-mediated plasma membrane repair","volume":"45","author":"Andrews","year":"2015","journal-title":"Semin. 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