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Now, myofibroblasts are not only recognized for their physiological role in tissue repair but also as cells that are key in promoting the development of fibrosis in all organs. In this Cell Science at a Glance and the accompanying poster, we provide an overview of the current understanding of central aspects of myofibroblast biology, such as their definition, activation from different precursors, the involved signaling pathways and most widely used models to study their function. Myofibroblasts will be placed into context with their extracellular matrix and with other cell types communicating in the fibrotic environment. Furthermore, the challenges and strategies to target myofibroblasts in anti-fibrotic therapies are summarized to emphasize their crucial role in disease progression.<\/jats:p>","DOI":"10.1242\/jcs.227900","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T12:44:37Z","timestamp":1594385077000},"source":"Crossref","is-referenced-by-count":295,"title":["The myofibroblast at a glance"],"prefix":"10.1242","volume":"133","author":[{"given":"Pardis","family":"Pakshir","sequence":"first","affiliation":[{"name":"University of Toronto 1 Laboratory of Tissue Repair and Regeneration, Faculty of Dentistry , , Toronto, ON M5G 1G6 , Canada"},{"name":"Institute of Biomaterials and Biomedical Engineering, University of Toronto 2 , Toronto, ON M5S 3G9 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Noskovicova","sequence":"additional","affiliation":[{"name":"University of Toronto 1 Laboratory of Tissue Repair and Regeneration, Faculty of Dentistry , , Toronto, ON M5G 1G6 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Lodyga","sequence":"additional","affiliation":[{"name":"University of Toronto 1 Laboratory of Tissue Repair and Regeneration, Faculty of Dentistry , , Toronto, ON M5G 1G6 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Ok","family":"Son","sequence":"additional","affiliation":[{"name":"University of Toronto 1 Laboratory of Tissue Repair and Regeneration, Faculty of Dentistry , , Toronto, ON M5G 1G6 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronen","family":"Schuster","sequence":"additional","affiliation":[{"name":"University of Toronto 1 Laboratory of Tissue Repair and Regeneration, Faculty of Dentistry , , Toronto, ON M5G 1G6 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Goodwin","sequence":"additional","affiliation":[{"name":"University of Nottingham 3 Nottingham NIHR Respiratory Biomedical Research Unit , , Nottingham NG7 2UH , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henna","family":"Karvonen","sequence":"additional","affiliation":[{"name":"University of Toronto 1 Laboratory of Tissue Repair and Regeneration, Faculty of Dentistry , , Toronto, ON M5G 1G6 , Canada"},{"name":"Medical Research Center Oulu, Oulu University Hospital and University of Oulu 4 Respiratory Medicine, Research Unit of Internal Medicine , , POB 20, 90029 Oulu , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0526-393X","authenticated-orcid":false,"given":"Boris","family":"Hinz","sequence":"additional","affiliation":[{"name":"University of Toronto 1 Laboratory of Tissue Repair and Regeneration, Faculty of Dentistry , , Toronto, ON M5G 1G6 , Canada"},{"name":"Institute of Biomaterials and Biomedical Engineering, University of Toronto 2 , Toronto, ON M5S 3G9 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2020,7,10]]},"reference":[{"key":"2024053020205820100_JCS227900C1","doi-asserted-by":"publisher","first-page":"1862","DOI":"10.1038\/jid.2014.90","article-title":"The nano-scale mechanical properties of the extracellular matrix regulate dermal fibroblast function","volume":"134","author":"Achterberg","year":"2014","journal-title":"J. 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