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The mechanical forces driving the differentiation of oligodendrocyte precursor cells into myelinating oligodendrocytes are largely unknown, but likely require the spatiotemporal regulation of the architecture and dynamics of the actin and actomyosin cytoskeletons. In this study, we analyzed the expression pattern of myosin motors during oligodendrocyte development. We report that oligodendrocyte differentiation is regulated by the synchronized expression and non-uniform distribution of several members of the myosin network, particularly non-muscle myosins 2B and 2C, which potentially operate as nanomechanical modulators of cell tension and myelin membrane expansion at different cell stages.<\/jats:p>\n               <jats:p>This article has an associated First Person interview with the first author of the paper.<\/jats:p>","DOI":"10.1242\/jcs.232264","type":"journal-article","created":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T20:35:36Z","timestamp":1593808536000},"source":"Crossref","is-referenced-by-count":13,"title":["Pushing myelination \u2013 developmental regulation of myosin expression drives oligodendrocyte morphological differentiation"],"prefix":"10.1242","volume":"133","author":[{"given":"Helena Sofia","family":"Domingues","sequence":"first","affiliation":[{"name":"International Iberian Nanotechnology Laboratory (INL) 1 , 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