{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T13:00:47Z","timestamp":1779886847843,"version":"3.53.1"},"reference-count":52,"publisher":"The Company of Biologists","issue":"6","license":[{"start":{"date-parts":[[2020,3,15]],"date-time":"2020-03-15T00:00:00Z","timestamp":1584230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"name":"EU"},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes for Health Research","doi-asserted-by":"crossref","award":["ENG-387575"],"award-info":[{"award-number":["ENG-387575"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Canadian Foundation for Innovation","award":["35258"],"award-info":[{"award-number":["35258"]}]},{"name":"National Contest for Life Foundation Germany"},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["425373668"],"award-info":[{"award-number":["425373668"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["HE 3220\/4-1"],"award-info":[{"award-number":["HE 3220\/4-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fondation Universitaire Armand-Frappier"},{"name":"Fond de Recherche du Quebec - Sant\u00e9"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Mutations in CLN3 are a cause of juvenile neuronal ceroid lipofuscinosis (JNCL), also known as Batten disease. Clinical manifestations include cognitive regression, progressive loss of vision and motor function, epileptic seizures and a significantly reduced lifespan. CLN3 localizes to endosomes and lysosomes, and has been implicated in intracellular trafficking and autophagy. However, the precise molecular function of CLN3 remains to be elucidated. Previous studies showed an interaction between CLN3 and Rab7A, a small GTPase that regulates several functions at late endosomes. We confirmed this interaction in live cells and found that CLN3 is required for the efficient endosome-to-TGN trafficking of the lysosomal sorting receptors because it regulates the Rab7A interaction with retromer. In cells lacking CLN3 or expressing CLN3 harbouring a disease-causing mutation, the lysosomal sorting receptors were degraded. We also demonstrated that CLN3 is required for the Rab7A\u2013PLEKHM1 interaction, which is required for fusion of autophagosomes to lysosomes. Overall, our data provide a molecular explanation behind phenotypes observed in JNCL and give an indication of the pathogenic mechanism behind Batten disease.<\/jats:p>\n               <jats:p>This article has an associated First Person interview with the first author of the paper.<\/jats:p>","DOI":"10.1242\/jcs.234047","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T15:17:02Z","timestamp":1581088622000},"source":"Crossref","is-referenced-by-count":44,"title":["CLN3 regulates endosomal function by modulating Rab7A\u2013effector interactions"],"prefix":"10.1242","volume":"133","author":[{"given":"Seda","family":"Yasa","sequence":"first","affiliation":[{"name":"Centre Armand-Frappier Sant\u00e9 Biotechnologie, Institut National de la Recherche Scientifique 1 , Laval , Canada \u2008 H7V 1B7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziana","family":"Modica","sequence":"additional","affiliation":[{"name":"Centre Armand-Frappier Sant\u00e9 Biotechnologie, Institut National de la Recherche Scientifique 1 , Laval , Canada \u2008 H7V 1B7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Sauvageau","sequence":"additional","affiliation":[{"name":"Centre Armand-Frappier Sant\u00e9 Biotechnologie, Institut National de la Recherche Scientifique 1 , Laval , Canada \u2008 H7V 1B7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abuzar","family":"Kaleem","sequence":"additional","affiliation":[{"name":"Institute for Molecular and Cellular Cognition, Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-Eppendorf 2 , 20251 Hamburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Hermey","sequence":"additional","affiliation":[{"name":"Institute for Molecular and Cellular Cognition, Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-Eppendorf 2 , 20251 Hamburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3312-9594","authenticated-orcid":false,"given":"Stephane","family":"Lefrancois","sequence":"additional","affiliation":[{"name":"Centre Armand-Frappier Sant\u00e9 Biotechnologie, Institut National de la Recherche Scientifique 1 , Laval , Canada \u2008 H7V 1B7"},{"name":"McGill University 3 Department of Anatomy and Cell Biology , , Montreal , Canada \u2008 H3A 0C7"},{"name":"Centre d'Excellence en Recherche sur les Maladies Orphelines - Fondation Courtois (CERMO-FC), Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al (UQAM) 4 , Montr\u00e9al , Canada \u2008 H2X 3Y7"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2020,3,16]]},"reference":[{"key":"2024061319165137800_JCS234047C1","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1016\/j.bbadis.2012.11.014","article-title":"Human pathology in NCL","volume":"1832","author":"Anderson","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"2024061319165137800_JCS234047C2","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1083\/jcb.200312055","article-title":"Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor","volume":"165","author":"Arighi","year":"2004","journal-title":"J. Cell Biol."},{"key":"2024061319165137800_JCS234047C3","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.ceb.2010.04.007","article-title":"Rab GEFs and GAPs","volume":"22","author":"Barr","year":"2010","journal-title":"Curr. Opin. Cell Biol."},{"key":"2024061319165137800_JCS234047C4","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.bbrc.2008.06.021","article-title":"Sortilin mediates the lysosomal targeting of cathepsins D and H","volume":"373","author":"Canuel","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2024061319165137800_JCS234047C5","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.bbrc.2007.12.015","article-title":"AP-1 and retromer play opposite roles in the trafficking of sortilin between the Golgi apparatus and the lysosomes","volume":"366","author":"Canuel","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2024061319165137800_JCS234047C6","doi-asserted-by":"publisher","first-page":"20483","DOI":"10.1074\/jbc.M602180200","article-title":"Autophagy is disrupted in a knock-in mouse model of juvenile neuronal ceroid lipofuscinosis","volume":"281","author":"Cao","year":"2006","journal-title":"J. Biol. Chem."},{"key":"2024061319165137800_JCS234047C7","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1074\/jbc.M504175200","article-title":"rab7 activity affects epidermal growth factor:epidermal growth factor receptor degradation by regulating endocytic trafficking from the late endosome","volume":"281","author":"Ceresa","year":"2006","journal-title":"J. Biol. Chem."},{"key":"2024061319165137800_JCS234047C8","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/B978-0-12-800177-6.00005-0","article-title":"Cell and molecular biology of epidermal growth factor receptor","volume":"313","author":"Ceresa","year":"2014","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"2024061319165137800_JCS234047C9","doi-asserted-by":"publisher","first-page":"14361","DOI":"10.1074\/jbc.M114.621706","article-title":"Unbiased cell-based screening in a neuronal cell model of batten disease highlights an interaction between Ca2+ homeostasis, autophagy, and CLN3 protein function","volume":"290","author":"Chandrachud","year":"2015","journal-title":"J. Biol. Chem."},{"key":"2024061319165137800_JCS234047C10","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1111\/j.1471-4159.2010.07158.x","article-title":"Lithium rescues the impaired autophagy process in CbCln3(Deltaex7\/8\/Deltaex7\/8) cerebellar cells and reduces neuronal vulnerability to cell death via IMPase inhibition","volume":"116","author":"Chang","year":"2011","journal-title":"J. Neurochem."},{"key":"2024061319165137800_JCS234047C11","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1038\/ng.2386","article-title":"Mutations in ABCD4 cause a new inborn error of vitamin B12 metabolism","volume":"44","author":"Coelho","year":"2012","journal-title":"Nat. Genet."},{"key":"2024061319165137800_JCS234047C12","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1126\/science.1231143","article-title":"Multiplex genome engineering using CRISPR\/Cas systems","volume":"339","author":"Cong","year":"2013","journal-title":"Science"},{"key":"2024061319165137800_JCS234047C13","doi-asserted-by":"publisher","first-page":"79","DOI":"10.2217\/clp.11.70","article-title":"The juvenile Batten disease protein, CLN3, and its role in regulating anterograde and retrograde post-Golgi trafficking","volume":"7","author":"Cotman","year":"2012","journal-title":"Clin. Lipidol."},{"key":"2024061319165137800_JCS234047C14","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1242\/jcs.055798","article-title":"The phosphatidylinositol 4-kinase PI4KIIIalpha is required for the recruitment of GBF1 to Golgi membranes","volume":"123","author":"Dumaresq-Doiron","year":"2010","journal-title":"J. Cell Sci."},{"key":"2024061319165137800_JCS234047C15","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/1471-2202-5-57","article-title":"Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis","volume":"5","author":"Fossale","year":"2004","journal-title":"BMC Neurosci."},{"key":"2024061319165137800_JCS234047C16","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.molcel.2011.04.024","article-title":"Distinct autophagosomal-lysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest","volume":"42","author":"Ganley","year":"2011","journal-title":"Mol. Cell"},{"key":"2024061319165137800_JCS234047C17","doi-asserted-by":"publisher","first-page":"11821","DOI":"10.1073\/pnas.0601617103","article-title":"Rabs and their effectors: achieving specificity in membrane traffic","volume":"103","author":"Grosshans","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024061319165137800_JCS234047C18","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1093\/hmg\/9.5.735","article-title":"Batten disease: evaluation of CLN3 mutations on protein localization and function","volume":"9","author":"Haskell","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"2024061319165137800_JCS234047C19","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1152\/physrev.00059.2009","article-title":"Role of Rab GTPases in membrane traffic and cell physiology","volume":"91","author":"Hutagalung","year":"2011","journal-title":"Physiol. Rev."},{"key":"2024061319165137800_JCS234047C20","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1111\/j.1600-0854.2009.00932.x","article-title":"Functional rescue of beta-adrenoceptor dimerization and trafficking by pharmacological chaperones","volume":"10","author":"Kobayashi","year":"2009","journal-title":"Traffic"},{"key":"2024061319165137800_JCS234047C21","doi-asserted-by":"publisher","first-page":"6430","DOI":"10.1093\/emboj\/cdg629","article-title":"The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin","volume":"22","author":"Lefrancois","year":"2003","journal-title":"EMBO J."},{"key":"2024061319165137800_JCS234047C22","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1093\/hmg\/ddt596","article-title":"Human iPSC models of neuronal ceroid lipofuscinosis capture distinct effects of TPP1 and CLN3 mutations on the endocytic pathway","volume":"23","author":"Lojewski","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"2024061319165137800_JCS234047C23","doi-asserted-by":"publisher","first-page":"3017","DOI":"10.1093\/hmg\/ddh321","article-title":"Interconnections of CLN3, Hook1 and Rab proteins link Batten disease to defects in the endocytic pathway","volume":"13","author":"Luiro","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"2024061319165137800_JCS234047C24","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1128\/MCB.06726-11","article-title":"The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting","volume":"32","author":"Mamo","year":"2012","journal-title":"Mol. Cell. Biol."},{"key":"2024061319165137800_JCS234047C25","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1083\/jcb.201607085","article-title":"The Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomes","volume":"216","author":"Marwaha","year":"2017","journal-title":"J. Cell Biol."},{"key":"2024061319165137800_JCS234047C26","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/1741-7007-2-24","article-title":"The docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K\/Akt cell survival pathway","volume":"2","author":"Mattoon","year":"2004","journal-title":"BMC Biol."},{"key":"2024061319165137800_JCS234047C27","doi-asserted-by":"publisher","first-page":"1984","DOI":"10.1111\/j.1600-0854.2008.00814.x","article-title":"Palmitoylation controls recycling in lysosomal sorting and trafficking","volume":"9","author":"McCormick","year":"2008","journal-title":"Traffic"},{"key":"2024061319165137800_JCS234047C28","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.molcel.2014.11.006","article-title":"PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3\/GABARAP proteins","volume":"57","author":"McEwan","year":"2015","journal-title":"Mol. Cell"},{"key":"2024061319165137800_JCS234047C29","doi-asserted-by":"publisher","first-page":"44925","DOI":"10.1074\/jbc.M205767200","article-title":"Quantitative assessment of beta1- and beta2-adrenergic receptor homo- and heterodimerization by bioluminescence resonance energy transfer","volume":"277","author":"Mercier","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2024061319165137800_JCS234047C30","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1111\/j.1600-0854.2008.00807.x","article-title":"Loss of the Batten disease gene CLN3 prevents exit from the TGN of the mannose 6-phosphate receptor","volume":"9","author":"Metcalf","year":"2008","journal-title":"Traffic"},{"key":"2024061319165137800_JCS234047C31","doi-asserted-by":"publisher","first-page":"2579","DOI":"10.1242\/jcs.199729","article-title":"Rab7 palmitoylation is required for efficient endosome-to-TGN trafficking","volume":"130","author":"Modica","year":"2017","journal-title":"J. Cell Sci."},{"key":"2024061319165137800_JCS234047C32","doi-asserted-by":"publisher","first-page":"2237","DOI":"10.1016\/j.bbadis.2015.05.011","article-title":"Genetics of the neuronal ceroid lipofuscinoses (Batten disease)","volume":"1852","author":"Mole","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"2024061319165137800_JCS234047C33","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1111\/jnc.13744","article-title":"Revisiting the neuronal localization and trafficking of CLN3 in juvenile neuronal ceroid lipofuscinosis","volume":"139","author":"Oetjen","year":"2016","journal-title":"J. Neurochem."},{"key":"2024061319165137800_JCS234047C34","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1083\/jcb.200907015","article-title":"FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport","volume":"188","author":"Pankiv","year":"2010","journal-title":"J. Cell Biol."},{"key":"2024061319165137800_JCS234047C35","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1038\/nrm1500","article-title":"Targeting Rab GTPases to distinct membrane compartments","volume":"5","author":"Pfeffer","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2024061319165137800_JCS234047C36","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1093\/hmg\/ddt008","article-title":"Altered localization, abnormal modification and loss of function of sigma receptor-1 in amyotrophic lateral sclerosis","volume":"22","author":"Prause","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"2024061319165137800_JCS234047C37","doi-asserted-by":"publisher","first-page":"3729","DOI":"10.1242\/jcs.017301","article-title":"RILP is required for the proper morphology and function of late endosomes","volume":"120","author":"Progida","year":"2007","journal-title":"J. Cell Sci."},{"key":"2024061319165137800_JCS234047C38","doi-asserted-by":"publisher","first-page":"e102593","DOI":"10.1371\/journal.pone.0102593","article-title":"FRET-assisted determination of CLN3 membrane topology","volume":"9","author":"Ratajczak","year":"2014","journal-title":"PLoS ONE"},{"key":"2024061319165137800_JCS234047C52","doi-asserted-by":"publisher","first-page":"17","DOI":"10.4161\/adip.22117","article-title":"Proteomic analysis of protein palmitoylation in adipocytes","volume":"2","author":"Ren","year":"2013","journal-title":"Adipocyte"},{"key":"2024061319165137800_JCS234047C39","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1083\/jcb.200804048","article-title":"Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7","volume":"183","author":"Rojas","year":"2008","journal-title":"J. Cell Biol."},{"key":"2024061319165137800_JCS234047C40","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"2024061319165137800_JCS234047C41","doi-asserted-by":"publisher","first-page":"9592","DOI":"10.1074\/jbc.RA119.008852","article-title":"Lysosomal proteome analysis reveals that CLN3-defective cells have multiple enzyme deficiencies associated with changes in intracellular trafficking","volume":"294","author":"Schmidtke","year":"2019","journal-title":"J. Biol. Chem."},{"key":"2024061319165137800_JCS234047C42","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1083\/jcb.200312034","article-title":"Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer","volume":"165","author":"Seaman","year":"2004","journal-title":"J. Cell Biol."},{"key":"2024061319165137800_JCS234047C43","doi-asserted-by":"publisher","first-page":"2371","DOI":"10.1242\/jcs.048686","article-title":"Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5","volume":"122","author":"Seaman","year":"2009","journal-title":"J. Cell Sci."},{"key":"2024061319165137800_JCS234047C44","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/nrm2748","article-title":"Endocytosis and signalling: intertwining molecular networks","volume":"10","author":"Sorkin","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2024061319165137800_JCS234047C45","doi-asserted-by":"publisher","first-page":"53625","DOI":"10.1074\/jbc.M410930200","article-title":"A dileucine motif and a cluster of acidic amino acids in the second cytoplasmic domain of the batten disease-related CLN3 protein are required for efficient lysosomal targeting","volume":"279","author":"Storch","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2024061319165137800_JCS234047C46","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1007\/s00018-011-0913-1","article-title":"Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments","volume":"69","author":"Uusi-Rauva","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"key":"2024061319165137800_JCS234047C47","doi-asserted-by":"publisher","first-page":"12110","DOI":"10.1074\/jbc.M809277200","article-title":"Rab7 regulates late endocytic trafficking downstream of multivesicular body biogenesis and cargo sequestration","volume":"284","author":"Vanlandingham","year":"2009","journal-title":"J. Biol. Chem."},{"key":"2024061319165137800_JCS234047C48","doi-asserted-by":"publisher","first-page":"2410","DOI":"10.1091\/mbc.e02-01-0031","article-title":"Neuronal ceroid lipofuscinoses are connected at molecular level: interaction of CLN5 protein with CLN2 and CLN3","volume":"13","author":"Vesa","year":"2002","journal-title":"Mol. Biol. Cell"},{"key":"2024061319165137800_JCS234047C49","doi-asserted-by":"publisher","first-page":"e55526","DOI":"10.1371\/journal.pone.0055526","article-title":"Alterations in ROS activity and lysosomal pH account for distinct patterns of macroautophagy in LINCL and JNCL fibroblasts","volume":"8","author":"Vidal-Donet","year":"2013","journal-title":"PLoS ONE"},{"key":"2024061319165137800_JCS234047C50","doi-asserted-by":"publisher","first-page":"11808","DOI":"10.1038\/ncomms11808","article-title":"Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway","volume":"7","author":"Wijdeven","year":"2016","journal-title":"Nat. Commun."},{"key":"2024061319165137800_JCS234047C51","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1242\/jcs.178095","article-title":"Mon1-Ccz1 activates Rab7 only on late endosomes and dissociates from the lysosome in mammalian cells","volume":"129","author":"Yasuda","year":"2016","journal-title":"J. Cell Sci."}],"container-title":["Journal of Cell Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1242\/jcs.234047","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/jcs\/article-pdf\/doi\/10.1242\/jcs.234047\/3513937\/jcs234047.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/jcs\/article-pdf\/doi\/10.1242\/jcs.234047\/2062545\/jcs_234047v1.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/jcs\/article-pdf\/doi\/10.1242\/jcs.234047\/3513937\/jcs234047.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T22:12:55Z","timestamp":1718316775000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/jcs\/article\/133\/6\/jcs234047\/224946\/CLN3-regulates-endosomal-function-by-modulating"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,15]]},"references-count":52,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,3,15]]}},"URL":"https:\/\/doi.org\/10.1242\/jcs.234047","relation":{},"ISSN":["1477-9137","0021-9533"],"issn-type":[{"value":"1477-9137","type":"electronic"},{"value":"0021-9533","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3,15]]},"article-number":"jcs234047"}}