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TRIM32 is characterized by six protein\u2013protein interaction domains termed NHL, various point mutations in which are associated with limb-girdle-muscular dystrophy 2H (LGMD2H). Here, we show that TRIM32 is an autophagy substrate. Lysosomal degradation of TRIM32 was dependent on ATG7 and blocked by knockout of the five autophagy receptors p62 (also known as SQSTM1), NBR1, NDP52 (also known as CALCOCO2), TAX1BP1 and OPTN, pointing towards degradation by selective autophagy. p62 directed TRIM32 to lysosomal degradation, while TRIM32 mono-ubiquitylated p62 on lysine residues involved in regulation of p62 activity. Loss of TRIM32 impaired p62 sequestration, while reintroduction of TRIM32 facilitated p62 dot formation and its autophagic degradation. A TRIM32LGMD2H disease mutant was unable to undergo autophagic degradation and to mono-ubiquitylate p62, and its reintroduction into the TRIM32-knockout cells did not affect p62 dot formation. In light of the important roles of autophagy and p62 in muscle cell proteostasis, our results point towards impaired TRIM32-mediated regulation of p62 activity as a pathological mechanisms in LGMD2H.<\/jats:p>","DOI":"10.1242\/jcs.236596","type":"journal-article","created":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T17:25:20Z","timestamp":1572888320000},"source":"Crossref","is-referenced-by-count":28,"title":["TRIM32, but not its muscular dystrophy-associated mutant, positively regulates and is targeted to autophagic degradation by p62\/SQSTM1"],"prefix":"10.1242","volume":"132","author":[{"given":"Katrine Stange","family":"Over\u00e5","sequence":"first","affiliation":[{"name":"University of Troms\u00f8 \u2013The Arctic University of Norway 1 Molecular Cancer Research Group, Department of Medical Biology , , 9037 Troms\u00f8 , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juncal","family":"Garcia-Garcia","sequence":"additional","affiliation":[{"name":"University of Troms\u00f8 \u2013The Arctic University of Norway 1 Molecular Cancer Research Group, Department of Medical Biology , , 9037 Troms\u00f8 , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zambarlal","family":"Bhujabal","sequence":"additional","affiliation":[{"name":"University of Troms\u00f8 \u2013The Arctic University of Norway 1 Molecular Cancer Research Group, Department of Medical Biology , , 9037 Troms\u00f8 , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Jain","sequence":"additional","affiliation":[{"name":"University of Troms\u00f8 \u2013The Arctic University of Norway 1 Molecular Cancer Research Group, Department of Medical Biology , , 9037 Troms\u00f8 , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aud","family":"\u00d8vervatn","sequence":"additional","affiliation":[{"name":"University of Troms\u00f8 \u2013The Arctic University of Norway 1 Molecular Cancer Research Group, Department of Medical Biology , , 9037 Troms\u00f8 , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth Bowitz","family":"Larsen","sequence":"additional","affiliation":[{"name":"University of Troms\u00f8 \u2013The Arctic University of Norway 1 Molecular Cancer Research Group, Department of Medical Biology , , 9037 Troms\u00f8 , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vojo","family":"Deretic","sequence":"additional","affiliation":[{"name":"Autophagy Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center 2 , Albuquerque, NM 87131 , USA"},{"name":"University of New Mexico Health Sciences Center 3 Department of Molecular Genetics and Microbiology , , Albuquerque, NM 87131 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terje","family":"Johansen","sequence":"additional","affiliation":[{"name":"University of Troms\u00f8 \u2013The Arctic University of Norway 1 Molecular Cancer Research Group, Department of Medical Biology , , 9037 Troms\u00f8 , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trond","family":"Lamark","sequence":"additional","affiliation":[{"name":"University of Troms\u00f8 \u2013The Arctic University of Norway 1 Molecular Cancer Research Group, Department of Medical Biology , , 9037 Troms\u00f8 , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2668-1708","authenticated-orcid":false,"given":"Eva","family":"Sj\u00f8ttem","sequence":"additional","affiliation":[{"name":"University of Troms\u00f8 \u2013The Arctic University of Norway 1 Molecular Cancer Research Group, Department of Medical Biology , , 9037 Troms\u00f8 , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2019,12,2]]},"reference":[{"key":"2024061318410474200_JCS236596C1","doi-asserted-by":"publisher","first-page":"25850","DOI":"10.1074\/jbc.M601655200","article-title":"The interaction of Piasy with Trim32, an E3-ubiquitin ligase mutated in limb-girdle muscular dystrophy type 2H, promotes Piasy degradation and regulates UVB-induced keratinocyte apoptosis through NFkappaB","volume":"281","author":"Albor","year":"2006","journal-title":"J. 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