{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:25:36Z","timestamp":1784287536909,"version":"3.55.0"},"reference-count":62,"publisher":"The Company of Biologists","issue":"14","license":[{"start":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T00:00:00Z","timestamp":1594771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"name":"Hong Kong Research Grant Council","award":["17118917"],"award-info":[{"award-number":["17118917"]}]},{"name":"Hong Kong Research Grant Council","award":["17115619"],"award-info":[{"award-number":["17115619"]}]},{"name":"Sanming Project of Medicine in Shenzhen, Sy\u00f6p\u00e4j\u00e4rjest\u00f6t"},{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Decidual macrophages constitute 20\u201330% of the total leukocytes in the uterus of pregnant women, regulating the maternal immune tolerance and placenta development. Abnormal number or activities of decidual macrophages (dMs) are associated with fetal loss and pregnancy complications, such as preeclampsia. Monocytes differentiate into dMs in a decidua-specific microenvironment. Despite their important roles in pregnancy, the exact factors that regulate the differentiation into dMs remain unclear. Glycodelin-A (PAEP, hereafter referred to as GdA) is a glycoprotein that is abundantly present in the decidua, and plays an important role in fetomaternal defense and placental development. It modulates the differentiation and activity of several immune cell types residing in the decidua. In this study, we demonstrated that GdA induces the differentiation of human monocytes into dM-like phenotypes in terms of transcriptome, cell surface marker expression, secretome, and regulation of trophoblast and endothelial cell functions. We found that Sialic acid-binding Ig-like lectin 7 (Siglec-7) mediates the binding and biological actions of GdA in a sialic acid-dependent manner. We, therefore, suggest that GdA, induces the polarization of monocytes into dMs to regulate fetomaternal tolerance and placental development.<\/jats:p>","DOI":"10.1242\/jcs.244400","type":"journal-article","created":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T13:55:21Z","timestamp":1591624521000},"source":"Crossref","is-referenced-by-count":25,"title":["Decidual glycodelin-A polarizes human monocytes into a decidual macrophage-like phenotype through Siglec-7"],"prefix":"10.1242","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3367-5990","authenticated-orcid":false,"given":"Madhavi","family":"Vijayan","sequence":"first","affiliation":[{"name":"The University of Hong Kong 1 Department of Obstetrics and Gynaecology, LKS Faculty of Medicine , , Hong Kong S.A.R"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1553-3478","authenticated-orcid":false,"given":"Cheuk-Lun","family":"Lee","sequence":"additional","affiliation":[{"name":"The University of Hong Kong 1 Department of Obstetrics and Gynaecology, LKS Faculty of Medicine , , Hong Kong S.A.R"},{"name":"The University of Hong Kong Shenzhen Key Laboratory of Fertility Regulation, The University of Hong Kong-Shenzhen Hospital 2 , Shenzhen , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0140-6665","authenticated-orcid":false,"given":"Vera H. 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