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MicroRNAs (miRNAs), known as regulators of gene expression, have been implicated in the regulation of embryo implantation. However, the role of miRNAs in endometrial receptivity during the pre-implantation period remains elusive. In this study, we report that the expression level of Sus scrofa (ssc)-miR-21-5p in porcine endometrium tissues was significantly increased from day 9 to day 12 of pregnancy. Knockdown of ssc-miR-21-5p inhibited proliferation and migration of endometrial epithelial cells (EECs), and induced their apoptosis. We verified that programmed cell death 4 (PDCD4) was a target gene of ssc-miR-21-5p. Inhibition of PDCD4 rescued the effect of ssc-miR-21-5p repression on EECs. Our results also revealed that knockdown of ssc-miR-21-5p impeded the phosphorylation of AKT (herein referring to AKT1) by targeting PDCD4, which further upregulated the expression of Bax, and downregulated the levels of Bcl2 and Mmp9. Furthermore, loss of function of Mus musculus (mmu)-miR-21-5p in vivo resulted in a decreased number of implanted mouse embryos. Taken together, knockdown of ssc-miR-21-5p hampers endometrial receptivity by modulating the PDCD4\/AKT pathway.<\/jats:p>","DOI":"10.1242\/jcs.248898","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T15:45:28Z","timestamp":1603467928000},"source":"Crossref","is-referenced-by-count":30,"title":["Ssc-miR-21-5p regulates endometrial epithelial cell proliferation, apoptosis and migration via the PDCD4\/AKT pathway"],"prefix":"10.1242","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2756-8072","authenticated-orcid":false,"given":"Renwu","family":"Hua","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Huazhong Agricultural University 1 Key Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction of the Ministry of Education and Key Laboratory of Swine Genetics and Breeding of the Ministry of Agriculture , , Wuhan , 430000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6296-4989","authenticated-orcid":false,"given":"Xiuling","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Huazhong Agricultural University 1 Key Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction of the Ministry of Education and Key Laboratory of Swine Genetics and Breeding of the Ministry of Agriculture , , Wuhan , 430000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5040-6779","authenticated-orcid":false,"given":"Wenchao","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Huazhong Agricultural University 1 Key Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction of the Ministry of Education and Key Laboratory of Swine Genetics and Breeding of the Ministry of Agriculture , , Wuhan , 430000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7586-7221","authenticated-orcid":false,"given":"Weisi","family":"Lian","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Huazhong Agricultural University 1 Key Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction of the Ministry of Education and Key Laboratory of Swine Genetics and Breeding of the Ministry of Agriculture , , Wuhan , 430000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7959-1867","authenticated-orcid":false,"given":"Qiaorui","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Huazhong Agricultural University 1 Key Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction of the Ministry of Education and Key Laboratory of Swine Genetics and Breeding of the Ministry of Agriculture , , Wuhan , 430000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1895-0373","authenticated-orcid":false,"given":"Dengying","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Huazhong Agricultural University 1 Key Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction of the Ministry of Education and Key Laboratory of Swine Genetics and Breeding of the Ministry of Agriculture , , Wuhan , 430000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2079-949X","authenticated-orcid":false,"given":"Yueying","family":"Wang","sequence":"additional","affiliation":[{"name":"Jining No.1 People's Hospital 2 Department of Reproductive Medicine , , Jining, 272000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7515-6497","authenticated-orcid":false,"given":"Minggang","family":"Lei","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Huazhong Agricultural University 1 Key Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction of the Ministry of Education and Key Laboratory of Swine Genetics and Breeding of the Ministry of Agriculture , , Wuhan , 430000, China"},{"name":"National Engineering Research Center for Livestock 3 , Wuhan , 430000, China"},{"name":"The Cooperative Innovation Center for Sustainable Pig Production 4 , Wuhan , 430000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2020,12,9]]},"reference":[{"key":"2024061319075119200_JCS248898C1","doi-asserted-by":"publisher","first-page":"e00086-19","DOI":"10.1128\/MCB.00086-19","article-title":"MicroRNA (miRNA)-to-miRNA regulation of programmed cell death 4 (PDCD4)","volume":"39","author":"Ajuyah","year":"2019","journal-title":"Mol. 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