{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T05:57:34Z","timestamp":1779170254223,"version":"3.51.4"},"reference-count":73,"publisher":"The Company of Biologists","issue":"15","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"crossref","award":["2018R1D1A1A02086060"],"award-info":[{"award-number":["2018R1D1A1A02086060"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002573","name":"Yonsei University","doi-asserted-by":"crossref","award":["2018-22-0072"],"award-info":[{"award-number":["2018-22-0072"]}],"id":[{"id":"10.13039\/501100002573","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Keratin 8 (K8) is the cytoskeletal intermediate filament protein of simple-type epithelia. Mutations in K8 predispose the affected individual and transgenic mouse to liver disease. However, the role of K8 in the lung has not been reported in mutant transgenic mouse models. Here, we investigated the susceptibility of two different transgenic mice expressing K8 Gly62\u2013Cys (Gly62 replaced with Cys) or Ser74\u2013Ala (Ser74 replaced with Ala) to lung injury. The mutant transgenic mice were highly susceptible to two independent acute and chronic lung injuries compared with control mice. Both K8 Gly62\u2013Cys mice and K8 Ser74\u2013Ala mice showed markedly increased mouse lethality (\u223c74% mutant mice versus \u223c34% control mice) and more severe lung damage, with increased inflammation and apoptosis, under L-arginine-mediated acute lung injury. Moreover, the K8 Ser74\u2013Ala mice had more severe lung damage, with extensive hemorrhage and prominent fibrosis, under bleomycin-induced chronic lung injury. Our study provides the first direct evidence that K8 mutations predispose to lung injury in transgenic mice.<\/jats:p>","DOI":"10.1242\/jcs.250167","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T15:26:39Z","timestamp":1625239599000},"source":"Crossref","is-referenced-by-count":2,"title":["Keratin 8 mutations in transgenic mice predispose to lung injury"],"prefix":"10.1242","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2752-750X","authenticated-orcid":false,"given":"Sujin","family":"Kim","sequence":"first","affiliation":[{"name":"Interdisciplinary Program of Integrated OMICS for Biomedical Science, Graduate School, Yonsei University, Seoul 03722, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5678-9838","authenticated-orcid":false,"given":"Younglan","family":"Lim","sequence":"additional","affiliation":[{"name":"Interdisciplinary Program of Integrated OMICS for Biomedical Science, Graduate School, Yonsei University, Seoul 03722, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0300-5240","authenticated-orcid":false,"given":"So-Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Interdisciplinary Program of Integrated OMICS for Biomedical Science, Graduate School, Yonsei University, Seoul 03722, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5089-8902","authenticated-orcid":false,"given":"Han-Na","family":"Yoon","sequence":"additional","affiliation":[{"name":"Interdisciplinary Program of Integrated OMICS for Biomedical Science, Graduate School, Yonsei University, Seoul 03722, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2964-3205","authenticated-orcid":false,"given":"Hayan","family":"Yi","sequence":"additional","affiliation":[{"name":"Interdisciplinary Program of Integrated OMICS for Biomedical Science, Graduate School, Yonsei University, Seoul 03722, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3177-2965","authenticated-orcid":false,"given":"Kwi-Hoon","family":"Jang","sequence":"additional","affiliation":[{"name":"Interdisciplinary Program of Integrated OMICS for Biomedical Science, Graduate School, Yonsei University, Seoul 03722, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3850-0126","authenticated-orcid":false,"given":"Nam-On","family":"Ku","sequence":"additional","affiliation":[{"name":"Interdisciplinary Program of Integrated OMICS for Biomedical Science, Graduate School, Yonsei University, Seoul 03722, Korea"},{"name":"Department of Bio-Convergence ISED, Underwood International College, Yonsei University, Seoul 03722, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2021,8,3]]},"reference":[{"key":"2021080310584872400_JCS250167C1","first-page":"185","article-title":"The pathogenesis of bleomycin-induced pulmonary fibrosis in mice","volume":"77","author":"Adamson","year":"1974","journal-title":"Am. 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