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These enzymes are ubiquitous in the eukarya domain, with 23 distinct zDHHC-encoding genes in the human genome. zDHHC enzymes mediate the bulk of S-acylation (also known as palmitoylation) reactions in cells, transferring acyl chains to cysteine thiolates, and in so-doing affecting the stability, localisation and function of several thousand proteins. Studies using purified components have shown that the minimal requirements for S-acylation are an appropriate zDHHC enzyme\u2013substrate pair and fatty acyl-CoA. However, additional proteins including GCP16 (also known as Golga7), Golga7b, huntingtin and selenoprotein K, have been suggested to regulate the activity, stability and trafficking of certain zDHHC enzymes. In this Review, we discuss the role of these accessory proteins as essential components of the cellular S-acylation system.<\/jats:p>","DOI":"10.1242\/jcs.251819","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T09:20:15Z","timestamp":1605604815000},"source":"Crossref","is-referenced-by-count":52,"title":["Accessory proteins of the zDHHC family of S-acylation enzymes"],"prefix":"10.1242","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3002-6810","authenticated-orcid":false,"given":"Christine","family":"Salaun","sequence":"first","affiliation":[{"name":"Strathclyde Institute of Pharmacy and Biomedical Sciences 1 , , Glasgow G4 0RE , UK"},{"name":"University of Strathclyde 1 , , Glasgow G4 0RE , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6820-2301","authenticated-orcid":false,"given":"Carolina","family":"Locatelli","sequence":"additional","affiliation":[{"name":"Strathclyde Institute of Pharmacy and Biomedical Sciences 1 , , Glasgow G4 0RE , UK"},{"name":"University of Strathclyde 1 , , Glasgow G4 0RE , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3710-0622","authenticated-orcid":false,"given":"Filip","family":"Zmuda","sequence":"additional","affiliation":[{"name":"Strathclyde Institute of Pharmacy and Biomedical Sciences 1 , , Glasgow G4 0RE , UK"},{"name":"University of Strathclyde 1 , , Glasgow G4 0RE , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Cabrera Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Universidad Complutense 2 Fac. de Ciencias Qu\u00edmicas , , Avda. 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