{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T03:40:41Z","timestamp":1791776441336,"version":"4.3.4"},"reference-count":128,"publisher":"The Company of Biologists","issue":"4","license":[{"start":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/www.biologists.com\/user-licence-1-1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Tensins are a family of focal adhesion proteins consisting of four members in mammals (TNS1, TNS2, TNS3 and TNS4). Their multiple domains and activities contribute to the molecular linkage between the extracellular matrix and cytoskeletal networks, as well as mediating signal transduction pathways, leading to a variety of physiological processes, including cell proliferation, attachment, migration and mechanical sensing in a cell. Tensins are required for maintaining normal tissue structures and functions, especially in the kidney and heart, as well as in muscle regeneration, in animals. This Review discusses our current understanding of the domain functions and biological roles of tensins in cells and mice, as well as highlighting their relevance to human diseases.<\/jats:p>","DOI":"10.1242\/jcs.254029","type":"journal-article","created":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T14:02:08Z","timestamp":1613570528000},"source":"Crossref","is-referenced-by-count":62,"title":["Tensins \u2013 emerging insights into their domain functions, biological roles and disease relevance"],"prefix":"10.1242","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0399-0201","authenticated-orcid":false,"given":"Yi-Chun","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Biochemical Science and Technology, National Taiwan University, Taipei 10617, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2675-9387","authenticated-orcid":false,"given":"Su Hao","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Medicine, University of California-Davis, Sacramento, CA 95817, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2021,2,17]]},"reference":[{"key":"2021042701093538700_JCS254029C1","doi-asserted-by":"publisher","first-page":"e20919","DOI":"10.1371\/journal.pone.0020919","article-title":"Cten is targeted by kras signalling to regulate cell motility in the colon and pancreas","volume":"6","author":"Al-Ghamdi","year":"2011","journal-title":"PLoS ONE"},{"key":"2021042701093538700_JCS254029C2","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1097\/MPA.0b013e3182557ceb","article-title":"C-terminal tensin-like gene functions as an oncogene and promotes cell motility in pancreatic cancer","volume":"42","author":"Al-Ghamdi","year":"2013","journal-title":"Pancreas"},{"key":"2021042701093538700_JCS254029C3","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1002\/path.2508","article-title":"C-terminal tensin-like (CTEN) is an oncogene which alters cell motility possibly through repression of E-cadherin in colorectal cancer\u2020","volume":"218","author":"Albasri","year":"2009","journal-title":"J. Pathol."},{"key":"2021042701093538700_JCS254029C4","doi-asserted-by":"publisher","first-page":"2997","DOI":"10.1038\/onc.2011.26","article-title":"Cten signals through integrin-linked kinase (ILK) and may promote metastasis in colorectal cancer","volume":"30","author":"Albasri","year":"2011","journal-title":"Oncogene"},{"key":"2021042701093538700_JCS254029C5","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s10549-010-0890-3","article-title":"CTEN (C-terminal tensin-like), a novel oncogene overexpressed in invasive breast carcinoma of poor prognosis","volume":"126","author":"Albasri","year":"2011","journal-title":"Breast Cancer Res. Treat."},{"key":"2021042701093538700_JCS254029C6","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1111\/febs.13600","article-title":"The extended human PTPome: a growing tyrosine phosphatase family","volume":"283","author":"Alonso","year":"2016","journal-title":"FEBS J."},{"key":"2021042701093538700_JCS254029C7","doi-asserted-by":"publisher","first-page":"84112","DOI":"10.18632\/oncotarget.21109","article-title":"Overexpression of CTEN relates to tumor malignant potential and poor outcomes of adenocarcinoma of the esophagogastric junction","volume":"8","author":"Aratani","year":"2017","journal-title":"Oncotarget"},{"key":"2021042701093538700_JCS254029C8","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1164\/rccm.201102-0192OC","article-title":"Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function","volume":"184","author":"Artigas","year":"2011","journal-title":"Am. J. Respir. Crit. Care"},{"key":"2021042701093538700_JCS254029C9","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.1038\/s41467-018-04193-w","article-title":"Mutations in six nephrosis genes delineate a pathogenic pathway amenable to treatment","volume":"9","author":"Ashraf","year":"2018","journal-title":"Nat. Commun."},{"key":"2021042701093538700_JCS254029C10","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1111\/iep.12300","article-title":"TGF\u03b21-induced cell motility but not cell proliferation is mediated through Cten in colorectal cancer","volume":"99","author":"Asiri","year":"2018","journal-title":"Int. J. Exp. Pathol."},{"key":"2021042701093538700_JCS254029C11","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1111\/pin.12811","article-title":"Cten promotes Epithelial-Mesenchymal Transition (EMT) in colorectal cancer through stabilisation of Src","volume":"69","author":"Asiri","year":"2019","journal-title":"Pathol. Int."},{"key":"2021042701093538700_JCS254029C12","doi-asserted-by":"publisher","first-page":"23452","DOI":"10.1074\/jbc.271.38.23452","article-title":"Platelet-derived growth factor-induced formation of tensin and phosphoinositide 3-kinase complexes","volume":"271","author":"Auger","year":"1996","journal-title":"J. Biol. Chem"},{"key":"2021042701093538700_JCS254029C13","doi-asserted-by":"publisher","first-page":"jcs242909","DOI":"10.1242\/jcs.242909","article-title":"Mechano-responsiveness of fibrillar adhesions on stiffness-gradient gels","volume":"133","author":"Barber-P\u00e9rez","year":"2020","journal-title":"J. Cell Sci."},{"key":"2021042701093538700_JCS254029C14","doi-asserted-by":"publisher","first-page":"3151","DOI":"10.1242\/dev.01907","article-title":"The Snail genes as inducers of cell movement and survival: implications in development and cancer","volume":"132","author":"Barrallo-Gimeno","year":"2005","journal-title":"Development"},{"key":"2021042701093538700_JCS254029C15","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.jtcvs.2014.08.087","article-title":"C-terminal tensin-like protein mediates invasion of human lung cancer cells and is regulated by signal transducer and activator of transcription 3","volume":"149","author":"Bennett","year":"2015","journal-title":"J. Thorac Cardiovasc. Surg."},{"key":"2021042701093538700_JCS254029C16","doi-asserted-by":"publisher","first-page":"9784","DOI":"10.1073\/pnas.171269898","article-title":"Nephrocystin interacts with Pyk2, p130Cas, and tensin and triggers phosphorylation of Pyk2","volume":"98","author":"Benzing","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042701093538700_JCS254029C17","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.bbrc.2019.11.153","article-title":"Tensin regulates pharyngeal pumping in Caenorhabditis elegans","volume":"522","author":"Bruns","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021042701093538700_JCS254029C18","doi-asserted-by":"publisher","first-page":"e83859","DOI":"10.1371\/journal.pone.0083859","article-title":"Identification of candidate driver genes in common focal chromosomal aberrations of microsatellite stable colorectal cancer","volume":"8","author":"Burghel","year":"2013","journal-title":"PLoS ONE"},{"key":"2021042701093538700_JCS254029C19","doi-asserted-by":"publisher","first-page":"2272","DOI":"10.1073\/pnas.262791999","article-title":"Integrin \u03b2 cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling","volume":"100","author":"Calderwood","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042701093538700_JCS254029C20","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1073\/pnas.1114368109","article-title":"Differential regulation of the activity of deleted in liver cancer 1 (DLC1) by tensins controls cell migration and transformation","volume":"109","author":"Cao","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042701093538700_JCS254029C21","doi-asserted-by":"publisher","first-page":"7721","DOI":"10.1038\/ncomms8721","article-title":"A phosphorylation switch controls the spatiotemporal activation of Rho GTPases in directional cell migration","volume":"6","author":"Cao","year":"2015","journal-title":"Nat. Commun."},{"key":"2021042701093538700_JCS254029C22","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/ncb1420","article-title":"p63 regulates an adhesion programme and cell survival in epithelial cells","volume":"8","author":"Carroll","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"2021042701093538700_JCS254029C23","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1016\/j.bbrc.2017.01.183","article-title":"Drosophila tensin plays an essential role in cell migration and planar polarity formation during oogenesis by mediating integrin-dependent extracellular signals to actin organization","volume":"484","author":"Cha","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021042701093538700_JCS254029C24","doi-asserted-by":"publisher","first-page":"e5572","DOI":"10.1371\/journal.pone.0005572","article-title":"Deleted in liver cancer 1 (DLC1) utilizes a novel binding site for tensin2 PTB domain interaction and is required for tumor-suppressive function","volume":"4","author":"Chan","year":"2009","journal-title":"PLoS ONE"},{"key":"2021042701093538700_JCS254029C25","doi-asserted-by":"publisher","first-page":"20964","DOI":"10.18632\/oncotarget.4122","article-title":"Tensin4 is up-regulated by EGF-induced ERK1\/2 activity and promotes cell proliferation and migration in hepatocellular carcinoma","volume":"6","author":"Chan","year":"2015","journal-title":"Oncotarget"},{"key":"2021042701093538700_JCS254029C26","doi-asserted-by":"publisher","first-page":"19799","DOI":"10.1073\/pnas.1911865116","article-title":"Force-induced recruitment of cten along keratin network in epithelial cells","volume":"116","author":"Cheah","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042701093538700_JCS254029C27","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1042\/BJ20021308","article-title":"Regulation of tensin-promoted cell migration by its focal adhesion binding and Src homology domain 2","volume":"370","author":"Chen","year":"2003","journal-title":"Biochem. J."},{"key":"2021042701093538700_JCS254029C28","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1073\/pnas.022518699","article-title":"Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration","volume":"99","author":"Chen","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042701093538700_JCS254029C29","doi-asserted-by":"publisher","first-page":"26104","DOI":"10.1074\/jbc.M112.360206","article-title":"Solution structure of the Phosphotyrosine Binding (PTB) domain of human tensin2 protein in complex with deleted in liver cancer 1 (DLC1) peptide reveals a novel peptide binding mode","volume":"287","author":"Chen","year":"2012","journal-title":"J. Biol. Chem."},{"key":"2021042701093538700_JCS254029C30","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.11817\/j.issn.1672-7347.2014.12.003","article-title":"Correlation between the expression of C-terminal tensin-like protein and the prognosis of hepatocellular carcinoma","volume":"39","author":"Chen","year":"2014","journal-title":"J. Cent. South Univ. Med. Sci."},{"key":"2021042701093538700_JCS254029C31","doi-asserted-by":"publisher","first-page":"8710","DOI":"10.1038\/s41598-017-09504-7","article-title":"Musashi-1 enhances glioblastoma cell migration and cytoskeletal dynamics through translational inhibition of tensin3","volume":"7","author":"Chen","year":"2017","journal-title":"Sci. Rep."},{"key":"2021042701093538700_JCS254029C32","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.ydbio.2004.12.027","article-title":"Inactivation of tensin3 in mice results in growth retardation and postnatal lethality","volume":"279","author":"Chiang","year":"2005","journal-title":"Dev. Biol."},{"key":"2021042701093538700_JCS254029C33","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/s00335-005-0167-z","article-title":"Deficiency of the tensin2 gene in the ICGN mouse: an animal model for congenital nephrotic syndrome","volume":"17","author":"Cho","year":"2006","journal-title":"Mamm. Genome"},{"key":"2021042701093538700_JCS254029C34","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1083\/jcb.128.6.1095","article-title":"Molecular cloning, expression, and mapping of the high affinity actin-capping domain of chicken cardiac tensin","volume":"128","author":"Chuang","year":"1995","journal-title":"J. Cell Biol."},{"key":"2021042701093538700_JCS254029C35","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1002\/jcb.22460","article-title":"Tensin 2 modulates cell contractility in 3D collagen gels through the RhoGAP DLC1","volume":"109","author":"Clark","year":"2010","journal-title":"J. Cell. Biochem."},{"key":"2021042701093538700_JCS254029C36","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/s0955-0674(99)00067-8","article-title":"Focal adhesions - the cytoskeletal connection","volume":"12","author":"Critchley","year":"2000","journal-title":"Curr. Opin. Cell Biol."},{"key":"2021042701093538700_JCS254029C37","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1158\/1541-7786.225.2.4","article-title":"Epidermal growth factor modulates tyrosine phosphorylation of a novel tensin family member, tensin3","volume":"2","author":"Cui","year":"2004","journal-title":"Mol. Cancer Res."},{"key":"2021042701093538700_JCS254029C38","doi-asserted-by":"publisher","first-page":"e21965","DOI":"10.1371\/journal.pone.0021965","article-title":"Solution structure of tensin2 SH2 domain and its phosphotyrosine-independent interaction with DLC-1","volume":"6","author":"Dai","year":"2011","journal-title":"PLoS ONE"},{"key":"2021042701093538700_JCS254029C39","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1126\/science.1708917","article-title":"Presence of an Sh2 domain in the actin-binding protein tensin","volume":"252","author":"Davis","year":"1991","journal-title":"Science"},{"key":"2021042701093538700_JCS254029C40","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1038\/ng.3383","article-title":"Genetic association analyses highlight biological pathways underlying mitral valve prolapse","volume":"47","author":"Dina","year":"2015","journal-title":"Nat. Genet."},{"key":"2021042701093538700_JCS254029C41","doi-asserted-by":"publisher","first-page":"jcs249557","DOI":"10.1242\/jcs.249557","article-title":"GDNF drives rapid tubule morphogenesis in a novel 3D in vitro model for ADPKD","volume":"133","author":"Dixon","year":"2020","journal-title":"J. Cell Sci."},{"key":"2021042701093538700_JCS254029C42","doi-asserted-by":"publisher","first-page":"17806","DOI":"10.1074\/jbc.M700944200","article-title":"Association of the tensin N-terminal protein-tyrosine phosphatase domain with the \u03b1 isoform of protein phosphatase-1 in focal adhesions","volume":"282","author":"Eto","year":"2007","journal-title":"J. Biol. Chem."},{"key":"2021042701093538700_JCS254029C43","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1016\/j.jaci.2013.10.030","article-title":"Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype","volume":"133","author":"Ferreira","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"2021042701093538700_JCS254029C44","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1038\/35099066","article-title":"Transmembrane crosstalk between the extracellular matrix and the cytoskeleton","volume":"2","author":"Geiger","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2021042701093538700_JCS254029C45","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1083\/jcb.201609066","article-title":"AMPK negatively regulates tensin-dependent integrin activity","volume":"216","author":"Georgiadou","year":"2017","journal-title":"J. Cell Biol."},{"key":"2021042701093538700_JCS254029C46","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1038\/s41388-017-0074-2","article-title":"Hic-5 regulates fibrillar adhesion formation to control tumor extracellular matrix remodeling through interaction with tensin1","volume":"37","author":"Goreczny","year":"2018","journal-title":"Oncogene"},{"key":"2021042701093538700_JCS254029C47","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1007\/s00018-012-1228-6","article-title":"Interaction of DISC1 with the PTB domain of Tensin2","volume":"70","author":"Goudarzi","year":"2013","journal-title":"Cell. Mol. Life Sci"},{"key":"2021042701093538700_JCS254029C48","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/S0006-291x(02)02718-3","article-title":"Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin","volume":"299","author":"Hafizi","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021042701093538700_JCS254029C49","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1096\/fj.04-2532fje","article-title":"C1-TEN is a negative regulator of the Akt\/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration","volume":"19","author":"Hafizi","year":"2005","journal-title":"FASEB J."},{"key":"2021042701093538700_JCS254029C50","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.biocel.2009.09.005","article-title":"Individual domains of tensin2 exhibit distinct subcellular localisations and migratory effects","volume":"42","author":"Hafizi","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"2021042701093538700_JCS254029C51","doi-asserted-by":"publisher","first-page":"34713","DOI":"10.1074\/jbc.M109.059592","article-title":"Tensin1 requires protein phosphatase-1\u03b1 in addition to RhoGAP DLC-1 to control cell polarization, migration, and invasion","volume":"284","author":"Hall","year":"2009","journal-title":"J. Biol. Chem."},{"key":"2021042701093538700_JCS254029C52","doi-asserted-by":"publisher","first-page":"2853","DOI":"10.1074\/mcp.M110.003665","article-title":"Comprehensive analysis of phosphorylation sites in tensin1 reveals regulation by p38MAPK","volume":"9","author":"Hall","year":"2010","journal-title":"Mol. Cell. Proteomics"},{"key":"2021042701093538700_JCS254029C53","doi-asserted-by":"publisher","first-page":"5716","DOI":"10.1002\/cam4.1834","article-title":"Aberrant CpG-methylation affects genes expression predicting survival in lung adenocarcinoma","volume":"7","author":"He","year":"2018","journal-title":"Cancer Med."},{"key":"2021042701093538700_JCS254029C54","doi-asserted-by":"publisher","first-page":"5662","DOI":"10.1523\/Jneurosci.2059-18.2019","article-title":"C. elegans tensin promotes axon regeneration by linking the met-like SVH-2 and integrin signaling pathways","volume":"39","author":"Hisamoto","year":"2019","journal-title":"J. Neurosci."},{"key":"2021042701093538700_JCS254029C55","doi-asserted-by":"publisher","first-page":"5266","DOI":"10.1158\/0008-5472.Can-12-4441","article-title":"CTEN prolongs signaling by EGFR through reducing its ligand-induced degradation","volume":"73","author":"Hong","year":"2013","journal-title":"Cancer Res."},{"key":"2021042701093538700_JCS254029C56","doi-asserted-by":"publisher","first-page":"38143","DOI":"10.18632\/oncotarget.9411","article-title":"Down-regulation of tensin2 enhances tumorigenicity and is associated with a variety of cancers","volume":"7","author":"Hong","year":"2016","journal-title":"Oncotarget"},{"key":"2021042701093538700_JCS254029C57","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.bbamcr.2018.10.008","article-title":"Identification of subcellular targeting sequences of Cten reveals its role in cell proliferation","volume":"1866","author":"Hong","year":"2019","journal-title":"Biochim. Biophys. Acta (BBA) Mol. Cell Res."},{"key":"2021042701093538700_JCS254029C58","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/S0092-8674(02)00971-6","article-title":"Integrins: bidirectional, allosteric signaling machines","volume":"110","author":"Hynes","year":"2002","journal-title":"Cell"},{"key":"2021042701093538700_JCS254029C59","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1042\/bj3560737","article-title":"A role of tensin in skeletal-muscle regeneration","volume":"356","author":"Ishii","year":"2001","journal-title":"Biochem. J."},{"key":"2021042701093538700_JCS254029C60","doi-asserted-by":"publisher","first-page":"17777","DOI":"10.1038\/s41598-017-18081-8","article-title":"Inhibition of C1-Ten PTPase activity reduces insulin resistance through IRS-1 and AMPK pathways","volume":"7","author":"Jeong","year":"2017","journal-title":"Sci. Rep."},{"key":"2021042701093538700_JCS254029C61","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.4161\/cc.10.11.15776","article-title":"Tensin2 is a novel mediator in thrombopoietin (TPO)-induced cellular proliferation by promoting Akt signaling","volume":"10","author":"Jung","year":"2011","journal-title":"Cell Cycle"},{"key":"2021042701093538700_JCS254029C62","doi-asserted-by":"publisher","first-page":"279","DOI":"10.2220\/biomedres.29.279","article-title":"The possible involvement of tensin2 in the expression and extension of nephrin by glomerular podocytes in mice","volume":"29","author":"Kato","year":"2008","journal-title":"Biomed. Res."},{"key":"2021042701093538700_JCS254029C63","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1097\/CCO.0b013e32835b6371","article-title":"TGF-\u03b2 signaling and epithelial\u2013mesenchymal transition in cancer progression","volume":"25","author":"Katsuno","year":"2013","journal-title":"Curr. Opin. Oncol."},{"key":"2021042701093538700_JCS254029C64","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1038\/ncb1622","article-title":"A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration","volume":"9","author":"Katz","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"2021042701093538700_JCS254029C65","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/j.bbrc.2009.01.095","article-title":"START-GAP2\/DLC2 is localized in focal adhesions via its N-terminal region","volume":"380","author":"Kawai","year":"2009","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"2021042701093538700_JCS254029C66","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.cellsig.2018.07.009","article-title":"Cellular phosphatase activity of C1-ten\/tensin2 is controlled by phosphatidylinositol-3,4,5-triphosphate binding through the C1-ten\/tensin2 SH2 domain","volume":"51","author":"Kim","year":"2018","journal-title":"Cell. Signal."},{"key":"2021042701093538700_JCS254029C67","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1038\/s41467-018-02942-5","article-title":"Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer","volume":"9","author":"Klein","year":"2018","journal-title":"Nat. Commun."},{"key":"2021042701093538700_JCS254029C68","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1128\/Mcb.01447-12","article-title":"C1-ten is a protein tyrosine phosphatase of insulin receptor substrate 1 (IRS-1), regulating IRS-1 stability and muscle atrophy","volume":"33","author":"Koh","year":"2013","journal-title":"Mol. Cell Biol."},{"key":"2021042701093538700_JCS254029C69","doi-asserted-by":"publisher","first-page":"4001","DOI":"10.1242\/dev.00595","article-title":"blistery encodes Drosophila tensin protein and interacts with integrin and the JNK signaling pathway during wing development","volume":"130","author":"Lee","year":"2003","journal-title":"Development"},{"key":"2021042701093538700_JCS254029C70","doi-asserted-by":"publisher","first-page":"12346","DOI":"10.1038\/s41598-017-12382-8","article-title":"C1-ten is a PTPase of nephrin, regulating podocyte hypertrophy through mTORC1 activation","volume":"7","author":"Lee","year":"2017","journal-title":"Sci. Rep."},{"key":"2021042701093538700_JCS254029C71","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1242\/jcs.041624","article-title":"Mechanisms that regulate adaptor binding to beta-integrin cytoplasmic tails","volume":"122","author":"Legate","year":"2009","journal-title":"J. Cell Sci."},{"key":"2021042701093538700_JCS254029C72","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1002\/bip.20862","article-title":"The PTB domain of tensin: NMR solution structure and phosphoinositides binding studies","volume":"89","author":"Leone","year":"2008","journal-title":"Biopolymers"},{"key":"2021042701093538700_JCS254029C73","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1083\/jcb.200608015","article-title":"The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1","volume":"176","author":"Liao","year":"2007","journal-title":"J. Cell Biol."},{"key":"2021042701093538700_JCS254029C74","doi-asserted-by":"publisher","first-page":"4563","DOI":"10.1158\/0008-5472.Can-09-0117","article-title":"Up-regulation of C-terminal tensin-like molecule promotes the tumorigenicity of colon cancer through \u03b2-catenin","volume":"69","author":"Liao","year":"2009","journal-title":"Cancer Res."},{"key":"2021042701093538700_JCS254029C75","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/s1357-2725(03)00171-7","article-title":"Tensin","volume":"36","author":"Lo","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"2021042701093538700_JCS254029C76","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.biocel.2014.04.003","article-title":"C-terminal tensin-like (CTEN): a promising biomarker and target for cancer","volume":"51","author":"Lo","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"2021042701093538700_JCS254029C77","first-page":"4217","article-title":"Cten, a COOH-terminal tensin-like protein with prostate restricted expression, is down-regulated in prostate cancer","volume":"62","author":"Lo","year":"2002","journal-title":"Cancer Res."},{"key":"2021042701093538700_JCS254029C78","doi-asserted-by":"publisher","first-page":"22310","DOI":"10.1016\/S0021-9258(17)31791-X","article-title":"Molecular cloning of chick cardiac muscle tensin - full-length cDNA sequence, expression, and characterization","volume":"269","author":"Lo","year":"1994","journal-title":"J. Biol. Chem."},{"key":"2021042701093538700_JCS254029C79","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1083\/jcb.125.5.1067","article-title":"Interactions of tensin with actin and identification of its three distinct actin-binding domains","volume":"125","author":"Lo","year":"1994","journal-title":"J. Cell Biol."},{"key":"2021042701093538700_JCS254029C80","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1083\/jcb.136.6.1349","article-title":"Progressive kidney degeneration in mice lacking tensin","volume":"136","author":"Lo","year":"1997","journal-title":"J. Cell Biol."},{"key":"2021042701093538700_JCS254029C81","doi-asserted-by":"publisher","first-page":"e0198823","DOI":"10.1371\/journal.pone.0198823","article-title":"CTEN induces epithelial-mesenchymal transition (EMT) and metastasis in non small cell lung cancer cells","volume":"13","author":"Lu","year":"2018","journal-title":"PLoS ONE"},{"key":"2021042701093538700_JCS254029C82","doi-asserted-by":"publisher","first-page":"e4350","DOI":"10.1371\/journal.pone.0004350","article-title":"Tensin3 is a negative regulator of cell migration and all four tensin family members are downregulated in human kidney cancer","volume":"4","author":"Martuszewska","year":"2009","journal-title":"PLoS ONE"},{"key":"2021042701093538700_JCS254029C83","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1292\/jvms.16-0205","article-title":"Functional validation of tensin2 SH2-PTB domain by CRISPR\/Cas9-mediated genome editing","volume":"78","author":"Marusugi","year":"2016","journal-title":"J. Vet. Med. Sci."},{"key":"2021042701093538700_JCS254029C84","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1110\/ps.072798707","article-title":"Structure of the PTB domain of tensin1 and a model for its recruitment to fibrillar adhesions","volume":"16","author":"McCleverty","year":"2007","journal-title":"Protein Sci."},{"key":"2021042701093538700_JCS254029C85","doi-asserted-by":"publisher","first-page":"601","DOI":"10.3390\/cancers11050601","article-title":"Molecular pathogenesis of gene regulation by the miR-150 duplex: miR-150-3p regulates TNS4 in lung adenocarcinoma","volume":"11","author":"Misono","year":"2019","journal-title":"Cancers"},{"key":"2021042701093538700_JCS254029C86","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.bbamcr.2011.10.001","article-title":"The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2","volume":"1823","author":"Moon","year":"2012","journal-title":"Biochim. Biophys. Acta (BBA) Mol. Cell Res."},{"key":"2021042701093538700_JCS254029C87","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.devcel.2014.03.024","article-title":"Tensin-4-dependent MET stabilization is essential for survival and proliferation in carcinoma cells","volume":"29","author":"Muharram","year":"2014","journal-title":"Dev. Cell"},{"key":"2021042701093538700_JCS254029C88","doi-asserted-by":"publisher","first-page":"2449","DOI":"10.1002\/jbmr.1936","article-title":"p130Cas, Crk-associated substrate, plays important roles in osteoclastic bone resorption","volume":"28","author":"Nagai","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"2021042701093538700_JCS254029C89","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1111\/apa.12204","article-title":"Investigation of novel genes for lung function in children and their interaction with tobacco smoke exposure: a preliminary report","volume":"102","author":"Panasevich","year":"2013","journal-title":"Acta Paediatr."},{"key":"2021042701093538700_JCS254029C90","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1083\/jcb.148.5.1075","article-title":"Integrin dynamics and matrix assembly: tensin-dependent translocation of alpha5beta1 integrins promotes early fibronectin fibrillogenesis","volume":"148","author":"Pankov","year":"2000","journal-title":"J. Cell Biol."},{"key":"2021042701093538700_JCS254029C91","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.molcel.2016.01.027","article-title":"SH2 domains serve as lipid-binding modules for pTyr-signaling proteins","volume":"62","author":"Park","year":"2016","journal-title":"Mol. Cell"},{"key":"2021042701093538700_JCS254029C92","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3390\/cells9010089","article-title":"Tensin-3 regulates integrin-mediated proliferation and differentiation of tonsil-derived mesenchymal stem cells","volume":"9","author":"Park","year":"2019","journal-title":"Cells-Basel"},{"key":"2021042701093538700_JCS254029C93","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1038\/nrm2957","article-title":"Cell adhesion: integrating cytoskeletal dynamics and cellular tension","volume":"11","author":"Parsons","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2021042701093538700_JCS254029C94","doi-asserted-by":"publisher","first-page":"9012","DOI":"10.1073\/pnas.0703033104","article-title":"Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities","volume":"104","author":"Qian","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042701093538700_JCS254029C95","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.ccr.2009.07.031","article-title":"The tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis","volume":"16","author":"Qian","year":"2009","journal-title":"Cancer Cell"},{"key":"2021042701093538700_JCS254029C96","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.celrep.2014.12.037","article-title":"Ligand-occupied integrin internalization links nutrient signaling to invasive migration","volume":"10","author":"Rainero","year":"2015","journal-title":"Cell Rep."},{"key":"2021042701093538700_JCS254029C97","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/ng.501","article-title":"Genome-wide association study identifies five loci associated with lung function","volume":"42","author":"Repapi","year":"2010","journal-title":"Nat. Genet."},{"key":"2021042701093538700_JCS254029C98","doi-asserted-by":"publisher","first-page":"2606","DOI":"10.1245\/s10434-008-9989-8","article-title":"Prognostic relevance of tensin4 expression in human gastric cancer","volume":"15","author":"Sakashita","year":"2008","journal-title":"Ann. Surg. Oncol."},{"key":"2021042701093538700_JCS254029C99","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1538\/expanim.19-0101","article-title":"Deletion of the tensin2 SH2-PTB domain, but not the loss of its PTPase activity, induces podocyte injury in FVB\/N mouse strain","volume":"69","author":"Sasaki","year":"2020","journal-title":"Exp. Anim."},{"key":"2021042701093538700_JCS254029C100","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/j.cell.2006.09.044","article-title":"Force sensing by mechanical extension of the Src family kinase substrate p130Cas","volume":"127","author":"Sawada","year":"2006","journal-title":"Cell"},{"key":"2021042701093538700_JCS254029C101","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.21873\/invivo.11171","article-title":"Clinical significance of tensin 4 gene expression in patients with gastric cancer","volume":"31","author":"Sawazaki","year":"2017","journal-title":"In Vivo"},{"key":"2021042701093538700_JCS254029C102","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.jid.2016.10.039","article-title":"Integrin-\u03b24-TNS4\u2013focal adhesion kinase signaling mediates keratinocyte proliferation in human skin","volume":"137","author":"Seo","year":"2017","journal-title":"J. Invest. Dermatol."},{"key":"2021042701093538700_JCS254029C103","doi-asserted-by":"publisher","first-page":"3258","DOI":"10.1016\/j.bbamcr.2015.09.028","article-title":"Tensin1 positively regulates RhoA activity through its interaction with DLC1","volume":"1853","author":"Shih","year":"2015","journal-title":"Biochim. Biophys. Acta (BBA) Mol. Cell Res."},{"key":"2021042701093538700_JCS254029C104","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.yexcr.2015.03.010","article-title":"SUV420H2 suppresses breast cancer cell invasion through down regulation of the SH2 domain-containing focal adhesion protein tensin-3","volume":"334","author":"Shinchi","year":"2015","journal-title":"Exp. Cell Res."},{"key":"2021042701093538700_JCS254029C105","doi-asserted-by":"publisher","first-page":"e80492","DOI":"10.1371\/journal.pone.0080492","article-title":"C-Terminal tensin-like protein is a novel prognostic marker for primary melanoma patients","volume":"8","author":"Sjoestroem","year":"2013","journal-title":"PLoS ONE"},{"key":"2021042701093538700_JCS254029C106","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1242\/jcs.195362","article-title":"Distinct focal adhesion protein modules control different aspects of mechanotransduction","volume":"130","author":"Stutchbury","year":"2017","journal-title":"J. Cell Sci."},{"key":"2021042701093538700_JCS254029C107","first-page":"109731","article-title":"Prazosin inhibits the proliferation and survival of acute myeloid leukaemia cells through down-regulating TNS1","volume":"124","author":"Sun","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"2021042701093538700_JCS254029C108","doi-asserted-by":"publisher","first-page":"984","DOI":"10.3390\/ijms19040984","article-title":"The sealing zone in osteoclasts: a self-organized structure on the bone","volume":"19","author":"Takito","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"2021042701093538700_JCS254029C109","doi-asserted-by":"publisher","first-page":"2601","DOI":"10.1002\/mc.22704","article-title":"Cten promotes epithelial-mesenchymal transition through the post-transcriptional stabilization of Snail","volume":"56","author":"Thorpe","year":"2017","journal-title":"Mol. Carcinog."},{"key":"2021042701093538700_JCS254029C110","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/S1534-5807(04)00055-3","article-title":"Tensin stabilizes integrin adhesive contacts in Drosophila","volume":"6","author":"Torgler","year":"2004","journal-title":"Dev. Cell"},{"key":"2021042701093538700_JCS254029C111","doi-asserted-by":"publisher","first-page":"3449","DOI":"10.1242\/jcs.184622","article-title":"Tensin 3 is a new partner of Dock5 that controls osteoclast podosome organization and activity","volume":"129","author":"Touaitahuata","year":"2016","journal-title":"J. Cell Sci."},{"key":"2021042701093538700_JCS254029C112","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1083\/jcb.201405105","article-title":"CDK5 is a major regulator of the tumor suppressor DLC1","volume":"207","author":"Tripathi","year":"2014","journal-title":"J. Cell Biol."},{"key":"2021042701093538700_JCS254029C113","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1159\/000354058","article-title":"Tenc1-deficient mice develop glomerular disease in a strain-specific manner","volume":"123","author":"Uchio-Yamada","year":"2013","journal-title":"Nephron Exp. Nephrol."},{"key":"2021042701093538700_JCS254029C114","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1292\/jvms.15-0442","article-title":"Tensin2-deficient mice on FVB\/N background develop severe glomerular disease","volume":"78","author":"Uchio-Yamada","year":"2016","journal-title":"J. Vet. Med. Sci."},{"key":"2021042701093538700_JCS254029C115","doi-asserted-by":"publisher","first-page":"2172","DOI":"10.1242\/jcs.200899","article-title":"A dual phenotype of MDA-MB-468 cancer cells reveals mutual regulation of tensin3 and adhesion plasticity","volume":"130","author":"Ve\u00df","year":"2017","journal-title":"J. Cell Sci."},{"key":"2021042701093538700_JCS254029C116","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1021\/cb600433g","article-title":"A chemical approach to the identification of tensin-binding proteins","volume":"2","author":"Wavreille","year":"2007","journal-title":"ACS Chem. Biol"},{"key":"2021042701093538700_JCS254029C117","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1083\/jcb.102.3.1085","article-title":"A re-examination of the interaction of vinculin with actin","volume":"102","author":"Wilkins","year":"1986","journal-title":"J. Cell Biol."},{"key":"2021042701093538700_JCS254029C118","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/nrm3769","article-title":"The integrin adhesome: from genes and proteins to human disease","volume":"15","author":"Winograd-Katz","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2021042701093538700_JCS254029C119","doi-asserted-by":"publisher","first-page":"3190","DOI":"10.3390\/ijms19103190","article-title":"Downregulation of C-terminal tensin-like protein (CTEN) suppresses prostate cell proliferation and contributes to acinar morphogenesis","volume":"19","author":"Wu","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"2021042701093538700_JCS254029C120","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1038\/s41419-019-2119-7","article-title":"Hyperactivity of Mek in TNS1 knockouts leads to potential treatments for cystic kidney diseases","volume":"10","author":"Wu","year":"2019","journal-title":"Cell Death Dis."},{"key":"2021042701093538700_JCS254029C121","doi-asserted-by":"publisher","first-page":"8367","DOI":"10.1158\/0008-5472.CAN-05-2850","article-title":"Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression","volume":"66","author":"Yam","year":"2006","journal-title":"Cancer Res."},{"key":"2021042701093538700_JCS254029C122","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1111\/resp.12212","article-title":"Association of five genetic variants with chronic obstructive pulmonary disease susceptibility and spirometric phenotypes in a Chinese Han population","volume":"19","author":"Yang","year":"2014","journal-title":"Respirology"},{"key":"2021042701093538700_JCS254029C123","doi-asserted-by":"publisher","first-page":"e0147542","DOI":"10.1371\/journal.pone.0147542","article-title":"\u0394Np63\u03b1 transcriptionally regulates the expression of CTEN that is associated with prostate cell adhesion","volume":"11","author":"Yang","year":"2016","journal-title":"PLoS ONE"},{"key":"2021042701093538700_JCS254029C124","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.1242\/jcs.114.20.3583","article-title":"Molecular complexity and dynamics of cell-matrix adhesions","volume":"114","author":"Zamir","year":"2001","journal-title":"J. Cell Sci."},{"key":"2021042701093538700_JCS254029C125","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.gene.2010.08.006","article-title":"Identification of novel families and classification of the C2 domain superfamily elucidate the origin and evolution of membrane targeting activities in eukaryotes","volume":"469","author":"Zhang","year":"2010","journal-title":"Gene"},{"key":"2021042701093538700_JCS254029C126","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1242\/bio.016428","article-title":"Association between tensin 1 and p130Cas at focal adhesions links actin inward flux to cell migration","volume":"5","author":"Zhao","year":"2016","journal-title":"Biol. Open"},{"key":"2021042701093538700_JCS254029C127","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s12885-016-2105-8","article-title":"Transgelin increases metastatic potential of colorectal cancer cells in vivo and alters expression of genes involved in cell motility","volume":"16","author":"Zhou","year":"2016","journal-title":"BMC Cancer"},{"key":"2021042701093538700_JCS254029C128","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.18632\/oncotarget.23275","article-title":"Elevated transgelin\/TNS1 expression is a potential biomarker in human colorectal cancer","volume":"9","author":"Zhou","year":"2018","journal-title":"Oncotarget"}],"container-title":["Journal of Cell Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.biologists.com\/jcs\/article-pdf\/doi\/10.1242\/jcs.254029\/1822615\/jcs254029.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/jcs\/article-pdf\/doi\/10.1242\/jcs.254029\/1822615\/jcs254029.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,17]],"date-time":"2022-12-17T20:49:15Z","timestamp":1671310155000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/jcs\/article\/134\/4\/jcs254029\/237381\/Tensins-emerging-insights-into-their-domain"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,15]]},"references-count":128,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,2,15]]}},"URL":"https:\/\/doi.org\/10.1242\/jcs.254029","relation":{},"ISSN":["0021-9533","1477-9137"],"issn-type":[{"value":"0021-9533","type":"print"},{"value":"1477-9137","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,15]]},"article-number":"jcs254029"}}